Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro

Neuroscience Letters

Volumn 599, Issue , 2015, Pages 109-114

  Machida, Takashi ^a   Takata, Fuyuko ^a,b   Matsumoto, Junichi ^a   Takenoshita, Hisayo ^a   Kimura, Ikuya ^a   Yamauchi, Atsushi ^a   Dohgu, Shinya ^a   Kataoka, Yasufumi ^a,b  

^a FUKUOKA UNIVERSITY   (Japan)

^b PharmaCo Cell Co Ltd   (Japan)

Author keywords

Blood brain barrier; Brain pericytes; Intracerebral hemorrhage; Matrix metalloproteinase 9; Protease activated receptors; Thrombin

Indexed keywords

1 AMINO 3 CYCLOPROPYLAMINO 7 (4 ISOPROPYLBENZYL) 7H PYRROLO[3,2 F]QUINAZOLINE; GELATINASE B; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; PROTEINASE ACTIVATED RECEPTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN PERICYTE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; GENE EXPRESSION; HEAT; IN VITRO STUDY; NONHUMAN; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; MICROVASCULATURE; PERICYTE; VASCULARIZATION; WISTAR RAT;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN; ENDOTHELIAL CELLS; MATRIX METALLOPROTEINASE 9; MICROVESSELS; PERICYTES; RATS, WISTAR; RECEPTORS, PROTEINASE-ACTIVATED; THROMBIN;

EID: 84930622573     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.05.028     Document Type: Article

References (34)

1. Sacco S., et al. Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry. Stroke 2009, 40(2):394-399.
2. Xi G., Keep R.F., Hoff J.T. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006, 5(1):53-63.
3. Yang G.Y., et al. Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J. Neurosurg. 1994, 81(1):93-102.
4. Wu H., et al. Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. Neurochem. Int. 2010, 57(3):248-253.
5. Lee K.R., et al. The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage. Acta Neurochir (Wien) 1996, 138(4):396-400. Discussion 400-1.
6. Xi G., et al. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke 1998, 29(12):2580-2586.
7. Lee K.R., et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model. J. Neurosurg. 1997, 86(2):272-278.
8. Lee Kevin R., et al. Edema from intracerebral hemorrhage: the role of thrombin. J. Neurosurg. 1996, 84(1):91-96.
9. Xue M., et al. Relative importance of proteinase-activated receptor-1 versus matrix metalloproteinases in intracerebral hemorrhage-mediated neurotoxicity in mice. Stroke 2009, 40(6):2199-2204.
10. Vergnolle N., et al. Protease-activated receptors in inflammation: neuronal signaling and pain. Trends Pharmacol. Sci. 2001, 22(3):146-152.
11. Luo W., Wang Y., Reiser G. Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection. Brain Res. Rev. 2007, 56(2):331-345.
12. Yan J., et al. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage. Stroke 2013, 44(5):1410-1417.
13. Wang J., et al. Role of protease-activated receptor-1 in brain injury after experimental global cerebral ischemia. Stroke 2012, 43(9):2476-2482.
14. Mao Y., et al. Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice. J. Cereb. Blood Flow Metab. 2010, 30(5):1044-1052.
15. Kawakita K., et al. Expression of matrix metalloproteinase-9 in thrombin-induced brain edema formation in rats. J. Stroke Cerebrovasc. Dis. 2006, 15(3):88-95.
16. Yong V.W. Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat. Rev. Neurosci. 2005, 6(12):931-944.
17. Takata F., et al. Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro. J. Neuroinflamm. 2011, 8:106.
18. Wang J., Tsirka S.E. Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage. Brain 2005, 128(Pt 7):1622-1633.
19. Xue M., et al. Contributions of multiple proteases to neurotoxicity in a mouse model of intracerebral haemorrhage. Brain 2009, 132(Pt 1):26-36.
20. Choi M.S., et al. Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes. Brain Res. Bull. 2008, 76(4):368-375.
21. Kolev K., et al. Matrix metalloproteinase-9 expression in post-hypoxic human brain capillary endothelial cells: H2O2 as a trigger and NF-kappaB as a signal transducer. Thromb. Haemost. 2003, 90(3):528-537.
22. Dohgu S., et al. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res. 2005, 1038(2):208-215.
23. Takata F., et al. Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells. Neurosci. Lett. 2008, 441(2):163-166.
24. Sumi N., et al. Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia. Cell. Mol. Neurobiol. 2010, 30(2):247-253.
25. Takata F., et al. Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway. Neurosci. Lett. 2009, 449(1):71-75.
26. Nakagawa S., et al. Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells. Cell. Mol. Neurobiol. 2007, 27(6):687-694.
27. McCarthy K.D., de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 1980, 85(3):890-902.
28. Bartha K., et al. Identification of thrombin receptors in rat brain capillary endothelial cells. J. Cereb. Blood Flow Metab. 2000, 20(1):175-182.
29. Vajda S., et al. Identification of protease-activated receptor-4 (PAR-4) in puromycin-purified brain capillary endothelial cells cultured on Matrigel. Neurochem. Int. 2008, 52(6):1234-1239.
30. Wang H., Ubl J.J., Reiser G. Four subtypes of protease-activated receptors: co-expressed in rat astrocytes, evoke different physiological signaling. Glia 2002, 37(1):53-63.
31. Chang C.J., et al. Thrombin regulates matrix metalloproteinase-9 expression in human monocytes. Biochem. Biophys. Res. Commun. 2009, 385(2):241-246.
32. Inaba H., et al. Involvement of protease-activated receptor 4 in over-expression of matrix metalloproteinase 9 induced by Porphyromonas gingivalis. Med. Microbiol. Immunol. 2015, (in press).
33. Wilson S.R., et al. Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors. Prostate 2004, 60(2):168-174.
34. Adams M.N., et al. Structure: function and pathophysiology of protease activated receptors. Pharmacol. Ther. 2011, 130(3):248-282.