A sensitive and reliable test instrument to assess swimming in rats with spinal cord injury

Behavioural Brain Research

Volumn 291, Issue , 2015, Pages 172-183

  Xu, Ning ^a   Åkesson, Elisabet ^a,b   Holmberg, Lena ^a   Sundström, Erik ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Stockholms Sjukhem Foundation   (Sweden)

Author keywords

Functional assessment; Motor performance; Spinal cord injury; Swimming

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY POSTURE; CONTROLLED STUDY; FEMALE; FUNCTIONAL STATUS; HINDLIMB; INJURY SEVERITY; LIMB MOVEMENT; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; SPINAL CORD INJURY; SWIMMING; WHITE MATTER; ANIMAL; BIOMECHANICS; CONVALESCENCE; DISEASE MODEL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SPINAL CORD; SPRAGUE DAWLEY RAT; THORACIC VERTEBRA; VALIDATION STUDY; VIDEORECORDING;

ANIMALS; BIOMECHANICAL PHENOMENA; DISEASE MODELS, ANIMAL; FEMALE; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SPINAL CORD; SPINAL CORD INJURIES; SWIMMING; THORACIC VERTEBRAE; VIDEO RECORDING;

EID: 84930616921     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2015.05.004     Document Type: Article

References (20)

1. Rosenzweig E.S., McDonald J.W. Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair. Curr Opin Neurol 2004, 17:121-131.
2. Åkesson E., Calzarossa C., Sundström E. Spinal cord injuries - principles and methods for outcome assessment. Animal models in spinal cord repair: neuromethods 2013, vol. 76:273-298. Humana Press.
3. Semler J., Wellmann K., Wirth F., Stein G., Angelova S., Ashrafi M., et al. Objective measures of motor dysfunction after compression spinal cord injury in adult rats: correlations with locomotor rating scores. J Neurotrauma 2011, 28:1247-1258.
4. Pajoohesh-Ganji A., Byrnes K.R., Fatemi G., Faden A.I. A combined scoring method to assess behavioral recovery after mouse spinal cord injury. Neurosci Res 2010, 67:117-125.
5. Hubli M., Dietz V. The physiological basis of neurorehabilitation - locomotor training after spinal cord injury. J Neuroeng Rehabil 2013, 10:5.
6. Onifer S.M., Smith G.M., Fouad K. Plasticity after spinal cord injury: relevance to recovery and approaches to facilitate it. Neurotherapeutics 2011, 8:283-293.
7. Nishimura Y., Isa T. Cortical and subcortical compensatory mechanisms after spinal cord injury in monkeys. Exp Neurol 2012, 235:152-161.
8. Gorska T., Chojnicka-Gittins B., Majczynski H., Zmyslowski W. Changes in forelimb-hindlimb coordination after partial spinal lesions of different extent in the rat. Behav Brain Res 2013, 239:121-138.
9. Tuszynski M.H., Steeves J.D., Fawcett J.W., Lammertse D., Kalichman M., Rask C., et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics. Spinal Cord 2007, 45:222-231.
10. Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995, 12:1-21.
11. Liebscher T., Schnell L., Schnell D., Scholl J., Schneider R., Gullo M., et al. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol 2005, 58:706-719.
12. Zorner B., Filli L., Starkey M.L., Gonzenbach R., Kasper H., Rothlisberger M., et al. Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents. Nat Methods 2010, 7:701-708.
13. Smith R.R., Burke D.A., Baldini A.D., Shum-Siu A., Baltzley R., Bunger M., et al. The Louisville Swim Scale: a novel assessment of Hindlimb function following spinal cord injury in adult rats. J Neurotrauma 2006, 23:1654-1670.
14. Gundersen H.J., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987, 147:229-263.
15. Schucht P., Raineteau O., Schwab M.E., Fouad K. Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord. Exp Neurol 2002, 176:143-153.
16. Sedy J., Urdzikova L., Jendelova P., Sykova E. Methods for behavioral testing of spinal cord injured rats. Neurosci Biobehav Rev 2008, 32:550-580.
17. Metz G.A., Merkler D., Dietz V., Schwab M.E., Fouad K. Efficient testing of motor function in spinal cord injured rats. Brain Res 2000, 883:165-177.
18. Muir G.D., Webb A.A. Assessment of behavioural recovery following spinal cord injury in rats. Eur J Neurosci 2000, 12:3079-3086.
19. Stoltz S., Humm J.L., Schallert T. Cortical injury impairs contralateral forelimb immobility during swimming: a simple test for loss of inhibitory motor control. Behav Brain Res 1999, 106:127-132.
20. Poon P.C., Gupta D., Shoichet M.S., Tator C.H. Clip compression model is useful for thoracic spinal cord injuries: histologic and functional correlates. Spine 2007, 32:2853-2859.