Objective measures of motor dysfunction after compression spinal cord injury in adult rats: Correlations with locomotor rating scores

Journal of Neurotrauma

Volumn 28, Issue 7, 2011, Pages 1247-1258

  Semler, Joerg ^a   Wellmann, Katharina ^a   Wirth, Felicitas ^a   Stein, Gregor ^a   Angelova, Srebrina ^a   Ashrafi, Mahak ^a   Schempf, Greta ^a   Ankerne, Janina ^a   Ozsoy, Ozlem ^b   Ozsoy, Umut ^b   Schönau, Eckhard ^a   Angelov, Doychin N ^a   Irintchev, Andrey ^c  

^a UNIVERSITY OF COLOGNE   (Germany)

^b AKDENIZ UNIVERSITY   (Turkey)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

BBB rating scale; compression spinal cord injury; locomotion; motion analysis; recovery of function

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CLIMBING; FEMALE; LIMB MOVEMENT; MOTION ANALYSIS SYSTEM; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; RAT; RATING SCALE; SPINAL CORD INJURY; VIDEORECORDING; WALKING;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GAIT DISORDERS, NEUROLOGIC; PARALYSIS; RATS; RATS, WISTAR; SPINAL CORD COMPRESSION;

EID: 79960521618     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2010.1737     Document Type: Article

References (29)

1. Apostolova, I., Irintchev, A., and Schachner, M. (2006). Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J. Neurosci. 26, 7849-7859. (Pubitemid 44315154) (Pubitemid 44315154)
2. Basso, D.M., Beattie, M.S., and Bresnahan, J.C. (1995). A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12, 1-21.
3. Basso, D.M., Beattie, M.S., and Bresnahan, J.C. (1996). Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 139, 244-256. (Pubitemid 26228093) (Pubitemid 26228093)
4. Basso, D.M. (2004). Behavioral testing after spinal cord injury: congruities, complexities, and controversies. J. Neurotrauma 21, 395-404. (Pubitemid 38509423) (Pubitemid 38509423)
5. Basso, D.M., Fisher, L.C., Anderson, A.J., Jakeman, L.B., McTigue, D.M., and Popovich, P.G. (2006). Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J. Neurotrauma 23, 635-659. (Pubitemid 43728052) (Pubitemid 43728052)
6. Chen, J., Joon Lee, H., Jakovcevski, I., Shah, R., Bhagat, N., Loers, G., Liu, H.Y., Meiners, S., Taschenberger, G., Kügler, S., Irintchev, A., and Schachner, M. (2010). The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration. Mol. Ther. 18, 1769-1777.
7. Chen, J., Wu, J., Apostolova, I., Skup, M., Irintchev, A., Kügler, S., and Schachner, M. (2007). Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury. Brain 130, 954-969. (Pubitemid 47355607) (Pubitemid 47355607)
8. Curtis, R., Green, D., Lindsay, R.M., and Wilkin, G.P. (1993). Upregulation of GAP-43 and growth of axons in rat spinal cord after compression injury. J. Neurocytol. 22, 51-64. (Pubitemid 23048814) (Pubitemid 23048814)
9. de Medinaceli, L., Freed, W., and Wyatt, R. (1982). An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp. Neurol. 77, 634-643. (Pubitemid 12011176) (Pubitemid 12011176)
10. Fouad, K., and Pearson, K. (2004). Restoring walking after spinal cord injury. Prog. Neurobiol. 73, 107-126. (Pubitemid 38759892) (Pubitemid 38759892)
11. Goldberger, M.E., Bregman, B.S., Vierck, C.J., and Brown, M. (1990). Criteria for assessing recovery of function after spinal cord injury: behavioral methods. Exp. Neurol. 107, 113-117. (Pubitemid 20058632) (Pubitemid 20058632)
12. Gundersen, H.J., and Jensen, E.B. (1987). The efficiency of systematic sampling in stereology and its prediction. J. Microsc. 147, 229-263.
13. Gundersen, H.J., Bendtsen, T.F., Korbo, L., Marcussen, N., Mller, A., Nielsen, K., Nyengaard, J.R., Pakkenberg, B., Srensen, F.B., and Vesterby, A. (1988). Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96, 379-394.
14. Hamers, F.P., Koopmans, G.C., and Joosten, E.A. (2006). Cat- Walk-assisted gait analysis in the assessment of spinal cord injury. J. Neurotrauma 23, 537-548. (Pubitemid 43726327) (Pubitemid 43726327)
15. Irintchev, A., Simova, O., Eberhardt, K., Morellini, F., and Schachner, M. (2005). Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice. Eur. J. Neurosci. 22, 802-808. (Pubitemid 41243322) (Pubitemid 41243322)
16. Jakovcevski, I., Wu, J., Karl, N., Leshchynska, I., Sytnyk, V., Chen, J., Irintchev, A., and Schachner, M. (2007). Glial scar expression of CHL1, the close homolog of the adhesion molecule L1, limits recovery after spinal cord injury. J. Neurosci. 27, 7222-7233. (Pubitemid 47037556) (Pubitemid 47037556)
17. Kesslak, J.P., and Keirstead, H.S. (2003). Assessment of behavior in animal models of spinal cord injury. J. Spinal Cord Med. 26, 323-328. (Pubitemid 37553154) (Pubitemid 37553154)
18. Kloos, A.D., Fisher, L.C., Detloff. M.R., Hassenzahl, D.L., and Basso, D.M. (2005). Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats. Exp. Neurol. 191, 251-265. (Pubitemid 40092868) (Pubitemid 40092868)
19. Koopmans, G.C., Deumens, R., Honig, W.M., Hamers, F.P., Steinbusch, H.W., and Joosten, E.A. (2005). The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination. J. Neurotrauma 22, 214-225. (Pubitemid 40333516) (Pubitemid 40333516)
20. Kunkel-Bagden, E., Dai, H.N., and Bregman, B.S. (1993). Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp. Neurol. 119, 153-164. (Pubitemid 23132012) (Pubitemid 23132012)
21. Lee, H., Jakovcevski, I., Radonjic, N., Hoelters, L., Schachner, M., and Irintchev, A. (2009). Better functional outcome of compression spinal cord injury in mice is associated with enhanced H-reflex responses. Exp. Neurol. 216, 365-374.
22. Martinez, M., Brezun, J.M., Bonnier, L., and Xerri, C. (2009). A new rating scale for open-field evaluation of behavioral recovery after cervical spinal cord injury in rats. J. Neurotrauma 26, 1043-1053.
23. Mehanna, A., Jakovcevski, I., Acar, A., Xiao, M., Loers, G., Rougon, G., Irintchev, A., and Schachner, M. (2010). Polysialic acid glycomimetic promotes functional recovery and plasticity after spinal cord injury in mice. Mol. Ther. 18, 34-43.
24. Muir, G.D., and Webb, A.A. (2000). Mini-review: assessment of behavioural recovery following spinal cord injury in rats. Eur. J. Neurosci. 12, 3079-3086.
25. Murray, M., Fischer, I., Smeraski, C., Tessler, A., and Giszter, S. (2004). Towards a definition of recovery of function. J. Neurotrauma 21, 405-413. (Pubitemid 38509424) (Pubitemid 38509424)
26. Webb, A.A., and Muir, G.D. (2005). Sensorimotor behaviour following incomplete cervical spinal cord injury in the rat. Behav. Brain Res. 165, 147-159. (Pubitemid 41565525) (Pubitemid 41565525)
27. West, M.J., and Gundersen, H.J. (1990). Unbiased stereological estimation of the number of neurons in the human hippocampus. J. Comp. Neurol. 296, 1-22. (Pubitemid 20174971) (Pubitemid 20174971)
28. Wrathall, J.R. (1992). Behavioral endpoint measures for preclinical trials using experimental models of spinal cord injury. J. Neurotrauma 9, 165-167; discussion 167-168.
29. Zörner, B., Filli, L., Starkey, M.L., Gonzenbach, R., Kasper, H., Röthlisberger, M., Bolliger, M., and Schwab, M.E. (2010). Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents. Nat. Methods 7, 701-708.