Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon

PLoS Neglected Tropical Diseases

Volumn 9, Issue 5, 2015, Pages

  Janssen, Saskia ^a,b,c,d,e   Hermans, Sabine ^a,e,f   Knap, Martijn ^a,c   Moekotte, Alma ^a,c   Rossatanga, Elie G ^b   Adegnika, Akim A ^c,d   Bélard, Sabine ^a,c,d,g   Hänscheid, Thomas ^c,h   Grobusch, Martin P ^a,c,d,e  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Centre de Traitement Ambulatoire (CTA)   (Gabon)

^c Centre de Recherche Médicale de Lambaréné CERMEL   (Gabon)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

^f MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^g CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^h Laboratorio de Microbiologia   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; COTRIMOXAZOLE;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CD4 LYMPHOCYTE COUNT; CROSS-SECTIONAL STUDY; FECES ANALYSIS; FEMALE; FOLLOW UP; GEOGRAPHIC DISTRIBUTION; HELMINTHIASIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PARASITE PREVALENCE; PROPHYLAXIS; TREATMENT DURATION; URINALYSIS; ADOLESCENT; ANIMAL; COMPLICATION; GABON; HIV INFECTIONS; IMMUNOLOGY; LOIASIS; MIDDLE AGED; STATISTICAL MODEL;

ADOLESCENT; ADULT; ANIMALS; ANTI-RETROVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CROSS-SECTIONAL STUDIES; FEMALE; GABON; HELMINTHIASIS; HIV INFECTIONS; HUMANS; LOGISTIC MODELS; LOIASIS; MALE; MIDDLE AGED; TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION;

EID: 84930615156     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003769     Document Type: Article

References (43)

1. Fincham JE, Markus MB, Adams VJ, Could control of soil-transmitted helminthic infection influence the HIV/AIDS pandemic. Acta Trop 2003; 86(2–3): 315–33. 12745135
2. Hotez PJ, Kamath A, Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis 2009; 3(8): e412. doi: 10.1371/journal.pntd.0000412 19707588
3. Harms G, Feldmeier H, HIV infection and tropical parasitic diseases—deleterious interactions in both directions? Trop Med Int Health 2002; 7(6): 479–88. 12031069
4. Slutsker L, Marston BJ, HIV and malaria: interactions and implications. Curr Opin Infect Dis 2007; 20(1): 3–10. 17197875
5. Walson J, Singa B, Sangaré L, Naulikha J, Piper B, Richardson B, et al. Empiric deworming to delay HIV disease progression in adults with HIV who are ineligible for initiation of antiretroviral treatment (the HEAT study): a multi-site, randomised trial. Lancet Infect Dis. 2012;12:925–32. doi: 10.1016/S1473-3099(12)70207-4 22971323
6. Vercruysse J, Albonico M, Behnke JM, Kotze AC, Prichard RK, McCarthy JS, et al. Is anthelmintic resistance a concern for the control of human soil-transmitted helminths? Int J Parasitol Drugs Drug Resist. 2011; 1(1): 14–27. doi: 10.1016/j.ijpddr.2011.09.002 24533260
7. Wang W, Wang L, Liang YS, Susceptibility or resistance of praziquantel in human schistosomiasis: a review. Parasitol Res. 2012; 111(5):1871–1877. doi: 10.1007/s00436-012-3151-z 23052781
8. Fokom-Domgue J, Pion SD, Gounoue R, Akame J, Nguipdop-Djomo P, Twum-Danso NA, et al. Absence of an association between Plasmodium falciparum infection and post-ivermectin Loa-related non-neurologic serious adverse events. Am J Trop Med Hyg. 2014; 90(2): 335–338. doi: 10.4269/ajtmh.13-0189 24420781
9. Bachur TP, Vale JM, Coelho IC, Queiroz TR, Chaves CS, Enteric parasitic infections in HIV/AIDS patients before and after the highly active antiretroviral therapy. Braz J Infect Dis 2008; 12(2): 115–22. 18641847
10. Adamu H, Wegayehu T, Petros B, High prevalence of diarrhoegenic intestinal parasite infections among non-ART HIV patients in Fitche Hospital, Ethiopia. PLoS One. 2013; 8(8):e72634. doi: 10.1371/journal.pone.0072634 23991132
11. Abate E, Belayneh M, Gelaw A, Idh J, Getachew A, Alemu S, et al. The impact of asymptomatic helminth co-infection in patients with newly diagnosed tuberculosis in north-west Ethiopia. PLoS One. 2012; 7(8): e42901. doi: 10.1371/journal.pone.0042901 22952620
12. Teklemariam Z, Abate D, Mitiku H, Dessie Y, Prevalence of intestinal parasitic infection among HIV positive persons who are naive and on antiretroviral treatment in Hiwot Fana Specialized University Hospital, Eastern Ethiopia. ISRN AIDS. 2013: 324329. doi: 10.1155/2013/324329 24052888
13. Taye B, Desta K, Ejigu S, Dori GU, The magnitude and risk factors of intestinal parasitic infection in relation to Human Immunodeficiency Virus infection and immune status, at ALERT Hospital, Addis Ababa, Ethiopia. Parasitol Int. 2014; 63(3): 550–6. doi: 10.1016/j.parint.2014.02.002 24603288
14. Ivan E, Crowther NJ, Rucogoza AT, Osuwat LO, Munyazesa E, Mutimura E, et al. Malaria and helminthic co-infection among HIV-positive pregnant women: prevalence and effects of antiretroviral therapy. Acta Trop. 2012; 124(3): 179–84. doi: 10.1016/j.actatropica.2012.08.004 22940013
15. Lacey E, Mode of action of benzimidazoles. Parasitol Today. 1990; 6(4): 112–5. 15463312
16. Chan K, Truong D, Shangari N, O'Brien PJ, Drug-induced mitochondrial toxicity. Expert Opin Drug Metab Toxicol. 2005; 1(4): 655–69. 16863431
17. van der Valk M, Casula M, Weverlingz GJ, van Kuijk K, van Eck-Smit B, Hulsebosch HJ, et al. Prevalence of lipoatrophy and mitochondrial DNA content of blood and subcutaneous fat in HIV-1-infected patients randomly allocated to zidovudine- or stavudine-based therapy. Antivir Ther. 2004; 9(3): 385–393. 15259901
18. Côté HC, Possible ways nucleoside analogues can affect mitochondrial DNA content and gene expression during HIV therapy. Antivir Ther. 2005;10 Suppl 2:M3–11. 16152702
19. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. Accessed 22 December 2014.
20. Flateau C, Le Loup G, Pialoux G, Consequences of HIV infection on malaria and therapeutic implications: a systematic review. Lancet Infect Dis. 2011; 11(7): 541–56. doi: 10.1016/S1473-3099(11)70031-7 21700241
21. World health organization, WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. 2007. http://www.who.int/hiv/pub/guidelines/HIVstaging150307.pdf. Accessed 20-03-2015.
22. van den Biggelaar AH, Rodrigues LC, van RR, van der Zee JS, Hoeksma-Kruize YC, Souverijn JH, et al. Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis 2004; 189(5): 892–900. 14976607
23. Adegnika AA, Ramharter M, Agnandji ST, Ateba NU, Issifou S, Yazdanbakhsh M, et al. Epidemiology of parasitic co-infections during pregnancy in Lambarene, Gabon. Trop Med Int Health 2010; 15(10): 1204–1209. doi: 10.1111/j.1365-3156.2010.02598.x 20636299
24. Akue JP, Nkoghe D, Padilla C, Moussavou G, Moukana H, Mbou RA, et al. Epidemiology of concomitant infection due to Loa loa and Mansonella perstans in Gabon. PLoS Negl Trop Dis 2011; 5(10): e1329. doi: 10.1371/journal.pntd.0001329 22022623
25. UNAIDS. Report on the Global AIDS Epidemic 2013. http://www.unaids.org/sites/default/files/media_asset/UNAIDS_Global_Report_2013_en_1.pdf. Accessed 22 December 2014.
26. Tarafder MR, Carabin H, Joseph L, Balolong E, JrOlveda R, McGarvey ST, Estimating the sensitivity and specificity of Kato-Katz stool examination technique for detection of hookworms, Ascaris lumbricoides and Trichuris trichiura infections in humans in the absence of a “gold standard.” Int. J. Parasitol. 2010; 40:399–404. doi: 10.1016/j.ijpara.2009.09.003 19772859
27. Koga K, Kasuya S, Khamboonruang C, Sukhavat K, Ieda M, Takatsuka N, et al. A modified agar plate method for detection of Strongyloides stercoralis. Am. J. Trop. Med. Hyg. 1991; 45:518–521. 1951861
28. Goldsmid JM, Studies on the laboratory diagnosis of human filariasis: preliminary communication. J Clin Path. 1970; 23: 632–635. 5529998
29. Pion SD, Demanou M, Oudin B, Boussinesq M, Loiasis: the individual factors associated with the presence of microfilaraemia. Ann Trop Med Parasitol. 2005;99(5): 491–500. 16004708
30. Rajan TV, Nelson FK, Shultz LD, Shultz KL, Beamer WG, Yates J, et al. Influence of gonadal steroids on susceptibility to Brugia malayi in scid mice. Acta Trop. 1994; 56(4): 307–14. 8023754
31. Walson JL, Stewart BT, Sangaré L, Mbogo LW, Otieno PA, Piper BK, et al. Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. PLoS Negl Trop Dis. 2010; 4(3): e644. doi: 10.1371/journal.pntd.0000644 20361031
32. Ivan E, Crowther NJ, Mutimura E, Osuwat LO, Janssen S, Grobusch MP, Helminthic infections rates and malaria in HIV-infected pregnant women on anti-retroviral therapy in Rwanda. PLoS Negl Trop Dis. 2013; 7(8): e2380. doi: 10.1371/journal.pntd.0002380 23967365
33. Janssen S, Rossatanga EG, Jurriaans S, ten Berge IJ, Grobusch MP, Triple infection with HIV-1, HTLV-1 and Strongyloides stercoralis, rendering CD4+ T-cell counts a misleading entity. Antivir Ther. 2013; 18(7): 949–51. doi: 10.3851/IMP2692 24152969
34. Elliott AM, Mawa PA, Joseph S, Namujju PB, Kizza M, Nakiyingi JS, et al. Associations between helminth infection and CD4+ T cell count, viral load and cytokine responses in HIV-1-infected Ugandan adults. Trans R Soc Trop Med Hyg. 2003; 97(1): 103–8. 12886815
35. Sangaré LR, Herrin BR, John-Stewart G, Walson JL, Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis. Parasitology. 2011; 138(12): 1546–58. doi: 10.1017/S0031182011000357 21729353
36. Webb EL, Ekii AO, Pala P, Epidemiology and immunology of helminth-HIV interactions. Curr Opin HIV AIDS 2012; 7(3): 245–53. doi: 10.1097/COH.0b013e32835210cd 22411451
37. Sharma RD, Bag S, Tawari NR, Degani MS, Goswami K, Reddy MV, Exploration of 2, 4-diaminopyrimidine and 2, 4-diamino-s-triazine derivatives as potential antifilarial agents. Parasitology. 2013; 140(8): 959–65. doi: 10.1017/S0031182013000309 23552564
38. Schweitzer BI, Dicker AP, Bertino JR, Dihydrofolate reductase as a therapeutic target. FASEB J. 1990;4:2441–52. 2185970
39. Reeves DS, Wilkinson PJ, The pharmacokinetics of trimethoprim and trimethoprim/sulphonamide combinations, including penetration into body tissues. Infection. 1979; 7 Suppl 4: S330–41. 389810
40. Noireau F, Apembet JD, Comparison of thick blood smear and saponin haemolysis for the detection of Loa loa and Mansonella perstans infections. J Trop Med Hyg. 1990; 93(6): 390–392. 2270002
41. Nikolay B, Brooker SJ, Pullan RL, Sensitivity of diagnostic tests for human soil-transmitted helminth infections: a meta-analysis in the absence of a true gold standard. Int J Parasitol. 2014; 44(11): 765–774. doi: 10.1016/j.ijpara.2014.05.009 24992655
42. Inês Ede J, Souza JN, Santos RC, Souza ES, Santos FL, Silva ML, et al. Efficacy of parasitological methods for the diagnosis of Strongyloides stercoralis and hookworm in faecal specimens. Acta Trop. 2011; 120(3): 206–210. doi: 10.1016/j.actatropica.2011.08.010 21896267
43. Adegnika AA, Zinsou JF, Issifou S, Ateba-Ngoa U, Kassa RF, Feugap EN, et al. Randomized, controlled, assessor-blind clinical trial to assess the efficacy of single- versus repeated-dose albendazole to treat Ascaris lumbricoides, Trichuris trichiura, and hookworm infection. Antimicrob Agents Chemother. 2014; 58(5): 2535–2540. doi: 10.1128/AAC.01317-13 24550339