Prediction of gestational diabetes through NMR metabolomics of maternal blood

Journal of Proteome Research

Volumn 14, Issue 6, 2015, Pages 2696-2706

  Pinto, Joana ^a   Almeida, Lara M ^a   Martins, Ana S ^a   Duarte, Daniela ^a   Barros, António S ^b   Galhano, Eulália ^c   Pita, Cristina ^c   Almeida, Maria Do Céu ^c   Carreira, Isabel M ^d   Gil, Ana M ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

gestational diabetes mellitus (GDM); lipid extracts; maternal plasma; metabolomics; NMR; prediagnosis GDM; pregnancy

Indexed keywords

ALANINE; BETAINE; CHOLESTEROL; CITRIC ACID; CREATINE; CREATININE; DIMETHYL SULFONE; FATTY ACID; GLUCOSE; GLUTAMINE; GLYCINE; HIGH DENSITY LIPOPROTEIN; LACTIC ACID; LOW DENSITY LIPOPROTEIN; METHANOL; PROLINE; PYRUVIC ACID; TRIACYLGLYCEROL; UREA; VALINE; VERY LOW DENSITY LIPOPROTEIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE CLASSIFICATION; FATTY ACID BLOOD LEVEL; FEMALE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HUMAN; LIPOPROTEIN BLOOD LEVEL; MATERNAL BLOOD; MATERNAL PLASMA; METABOLOMICS; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SENSITIVITY ANALYSIS; SPECTROMETER; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; DIABETES, GESTATIONAL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREGNANCY; PROCEDURES;

CASE-CONTROL STUDIES; DIABETES, GESTATIONAL; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; PREGNANCY;

EID: 84930608529     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.5b00260     Document Type: Article

References (34)

1. Creasy, R. K.; Resnik, R.; Iams, J. D. Creasy and Resniks Maternal-Fetal Medicine: Principles and Practice, 6 th ed.; Saunders Elsevier: Philadelphia, 2009.
2. Guariguata, L.; Linnenkamp, U.; Beagley, J.; Whiting, D. R.; Cho, N. H. Global estimates of the prevalence of hyperglycaemia in pregnancy Diabetes Res. Clin. Pract. 2014, 103, 176-185
3. Buckley, B. S.; Harreiter, J.; Damm, P.; Corcoy, R.; Chico, A.; Simmons, D.; Vellinga, A.; Dunne, F. on behalf of the, D. C. I. G. Gestational diabetes mellitus in Europe: prevalence, current screening practice and barriers to screening Diabetic Med. 2011, 29, 844-854
4. American Diabetes Association Standards of medical care in diabetes-2015 Diabetes Care 2014, 38 (Suppl 1) S1-S93
5. Metzger, B. E.; Gabbe, S. G.; Persson, B.; Buchanan, T. A.; Catalano, P. A.; Damm, P.; Dyer, A. R.; Leiva, A. de; Hod, M.; Kitzmiler, J. L. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy Diabetes Care 2010, 33, 676-682
6. Huynh, J.; Xiong, G.; Bentley-Lewis, R. A systematic review of metabolite profiling in gestational diabetes mellitus Diabetologia 2014, 57, 2453-2464
7. Chen, X. H.; Scholl, T. O.; Leskiw, M.; Savaille, J.; Stein, T. P. Differences in Maternal Circulating Fatty Acid Composition and Dietary Fat Intake in Women With Gestational Diabetes Mellitus or Mild Gestational Hyperglycemia Diabetes Care 2010, 33, 2049-2054
8. Scholtens, D. M.; Muehlbauer, M. J.; Daya, N. R.; Stevens, R. D.; Dyer, A. R.; Lowe, L. P.; Metzger, B. E.; Newgard, C. B.; Bain, J. R.; Lowe, W. L. Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy Diabetes Care 2014, 37, 158-166
9. Dudzik, D.; Zorawski, M.; Skotnicki, M.; Zarzycki, W.; Kozlowska, G.; Bibik-Malinowska, K.; Vallejo, M.; García, A.; Barbas, C.; Ramos, M. P. Metabolic fingerprint of Gestational Diabetes Mellitus J. Proteomics 2014, 103, 57-71
10. Sachse, D.; Sletner, L.; Mørkrid, K.; Jenum, A. K.; Birkeland, K. I.; Rise, F.; Piehler, A. P.; Berg, J. P. Metabolic changes in urine during and after pregnancy in a large, multiethnic population-based cohort study of gestational diabetes PLoS One 2012, 7, e52399
11. Dani, C.; Bresci, C.; Berti, E.; Ottanelli, S.; Mello, G.; Mecacci, F.; Breschi, R.; Hu, X.; Tenori, L.; Luchinat, C. Metabolomic profile of term infants of gestational diabetic mothers J. Matern. Fetal Neonatal Med. 2014, 27, 537-542
12. Peng, S.; Zhang, J.; Liu, L.; Zhang, X.; Huang, Q.; Alamdar, A.; Tian, M.; Shen, H. Newborn Meconium and Urinary Metabolome Response to Maternal Gestational Diabetes Mellitus: A Preliminary Case-Control Study J. Proteome Res. 2015, 14, 1799-1809
13. Graça, G.; Duarte, I. F.; Barros, A. S.; Goodfellow, B. J.; Diaz, S. O.; Pinto, J.; Carreira, I. M.; Galhano, E.; Pita, C.; Gil, A. M. Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study J. Proteome Res. 2010, 9, 6016-6024
14. Diaz, S. O.; Pinto, J.; Graça, G.; Duarte, I. F.; Barros, A. S.; Galhano, E.; Pita, C.; Almeida, M. do C.; Goodfellow, B. J.; Carreira, I. M. Metabolic Biomarkers of Prenatal Disorders: An Exploratory NMR Metabonomics Study of Second Trimester Maternal Urine and Blood Plasma J. Proteome Res. 2011, 10, 3732-3742
15. De Seymour, J. V.; Conlon, C. A.; Sulek, K.; Villas Bôas, S. G.; McCowan, L. M. E.; Kenny, L. C.; Baker, P. N. Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus Acta Diabetol. 2014, 51, 887-890
16. Bentley-Lewis, R.; Huynh, J.; Xiong, G.; Lee, H.; Wenger, J.; Clish, C.; Nathan, D.; Thadhani, R.; Gerszten, R. Metabolomic profiling in the prediction of gestational diabetes mellitus Diabetologia 2015, 58, 1329-1332
17. Diaz, S. O.; Barros, A. S.; Goodfellow, B. J.; Duarte, I. F.; Galhano, E.; Pita, C.; Almeida, M. do C.; Carreira, I. M.; Gil, A. M. Second trimester maternal urine for the diagnosis of trisomy 21 and prediction of poor pregnancy outcomes J. Proteome Res. 2013, 12, 2946-2957
18. Pinto, J.; Domingues, M. R. M.; Galhano, E.; Pita, C.; Almeida, M. do C.; Carreira, I. M.; Gil, A. M. Human plasma stability during handling and storage: impact on NMR metabolomics Analyst 2014, 139, 1168-1177
19. Pinto, J.; Barros, A. S.; Domingues, M. R. M.; Goodfellow, B. J.; Galhano, E.; Pita, C.; Almeida, M. C.; Carreira, I. M.; Gil, A. M. Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine J. Proteome Res. 2014, 14, 1263-1274
20. Matyash, V.; Liebisch, G.; Kurzchalia, T. V.; Shevchenko, A.; Schwudke, D. Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics J. Lipid Res. 2008, 49, 1137-1146
21. Wishart, D. S.; Tzur, D.; Knox, C.; Eisner, R.; Guo, A. C.; Young, N.; Cheng, D.; Jewell, K.; Arndt, D.; Sawhney, S. HMDB: the Human Metabolome Database Nucleic Acids Res. 2007, 35, D521-D526
22. Seavey, B. R.; Farr, E. A.; Westler, W. M.; Markley, J. L. A relational database for sequence-specific protein NMR data J. Biomol. NMR 1991, 1, 217-236
23. 1H NMR Data Sets Anal. Chem. 2005, 77, 1282-1289
24. 1H NMR spectra for improved metabolic biomarker recovery Anal. Chem. 2009, 81, 56-66
25. 1H NMR metabonomics Anal. Chem. 2006, 78, 4281-4290
26. Westerhuis, J. A.; Hoefsloot, H. C. J.; Smit, S.; Vis, D. J.; Smilde, A. K.; van Velzen, E.; van Duijnhoven, J.; van Dorsten, F.; Velzen, E. J. J.; Duijnhoven, J. P. M. Assessment of PLSDA cross validation Metabolomics 2008, 4, 81-89
27. R. D. C. Team. R: A Language and Environment for Statistical Computing, 2.14.1 ed.; R Foundation for Statistical Computing: Vienna, Austria, 2010.
28. Berben, L.; Sereika, S. M.; Engberg, S. Effect size estimation: methods and examples Int. J. Nurs. Stud. 2012, 49, 1039-1047
29. Dos Santos-Weiss, I. C. R.; Réa, R. R.; Fadel-Picheth, C. M. T.; Rego, F. G. M.; Pedrosa, F. de O.; Gillery, P.; Souza, E. M.; Picheth, G. The plasma logarithm of the triglyceride/HDL-cholesterol ratio is a predictor of low risk gestational diabetes in early pregnancy Clin. Chim. Acta 2013, 418, 1-4
30. Emet, T.; Ustüner, I.; Güven, S. G.; Ballk, G.; Ural, U. M.; Tekin, Y. B.; Sentürk, S.; Sahin, F. K.; Avşar, A. F. Plasma lipids and lipoproteins during pregnancy and related pregnancy outcomes Arch. Gynecol. Obstet. 2013, 288, 49-55
31. Christensen, B. L.; Williams, M. Assessing postprandial glucose using 1,5-anhydroglucitol: An integrative literature review J. Am. Acad. Nurse Practitioners 2009, 21, 542-548
32. Wang, Z.; Klipfell, E.; Bennett, B. J.; Koeth, R.; Levison, B. S.; Dugar, B.; Feldstein, A. E.; Britt, E. B.; Fu, X.; Chung, Y.-M. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Nature 2011, 472, 57-63
33. Everard, A.; Cani, P. D. Diabetes, obesity and gut microbiota Best Pract. Res., Clin. Gastroenterol. 2013, 27, 73-83
34. Tarim, E.; Bagis, T.; Kilicdag, E.; Erkanli, S.; Aslan, E.; Sezgin, N.; Kuscu, E. Elevated plasma homocysteine levels in gestational diabetes mellitus Acta Obstet. Gynecol. Scand. 2004, 83, 543-547