-
1
-
-
79960245246
-
The addition of arsenic trioxide to low-dose Ara-C in older patients with AML does not improve outcome
-
Burnett AK, Hills RK, Hunter A, Milligan D, Kell J, Wheatley K et al. The addition of arsenic trioxide to low-dose Ara-C in older patients with AML does not improve outcome. Leukemia 2011; 25: 1122-1127.
-
(2011)
Leukemia
, vol.25
, pp. 1122-1127
-
-
Burnett, A.K.1
Hills, R.K.2
Hunter, A.3
Milligan, D.4
Kell, J.5
Wheatley, K.6
-
2
-
-
77449159668
-
Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
-
Kantarjian HM, Erba HP, Claxton D, Arellano M, Lyons RM, Kovascovics T et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol 2010; 28: 549-555.
-
(2010)
J Clin Oncol
, vol.28
, pp. 549-555
-
-
Kantarjian, H.M.1
Erba, H.P.2
Claxton, D.3
Arellano, M.4
Lyons, R.M.5
Kovascovics, T.6
-
3
-
-
77952491723
-
European development of clofarabine as treatment for older patients with acute myeloid leukemia not considered unsuitable for intensive chemotherapy
-
Burnett AK, Russell NH, Kell J, Dennis M, Milligan D, Paolini S et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia not considered unsuitable for intensive chemotherapy. J Clin Oncol 2010; 28: 2389-2395.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2389-2395
-
-
Burnett, A.K.1
Russell, N.H.2
Kell, J.3
Dennis, M.4
Milligan, D.5
Paolini, S.6
-
4
-
-
84886859143
-
Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival
-
Burnett AK, Russell NH, Hunter AE, Milligan D, Knapper S, Wheatley K et al. Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival. Blood 2013; 122: 1384-1394.
-
(2013)
Blood
, vol.122
, pp. 1384-1394
-
-
Burnett, A.K.1
Russell, N.H.2
Hunter, A.E.3
Milligan, D.4
Knapper, S.5
Wheatley, K.6
-
5
-
-
84864295735
-
The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML
-
Burnett AK, Russell NH, Culligan D, Cavanagh J, Kell J, Wheatley K et al. The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML. Br J Haematol 2012; 158: 519-522.
-
(2012)
Br J Haematol
, vol.158
, pp. 519-522
-
-
Burnett, A.K.1
Russell, N.H.2
Culligan, D.3
Cavanagh, J.4
Kell, J.5
Wheatley, K.6
-
6
-
-
77449149373
-
Azacytidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
-
Fenaux P, Mufti GJ, Hellstrom-Liindberg E, Santini V, Gattermann N, Germing U et al. Azacytidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010; 28: 562-569.
-
(2010)
J Clin Oncol
, vol.28
, pp. 562-569
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Liindberg, E.3
Santini, V.4
Gattermann, N.5
Germing, U.6
-
7
-
-
84921436355
-
Results of a phase 3, multicenter, randomised, open-label study of azacitidine (AZA) vs. Conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukaemia (AML)
-
abstract LB2433
-
Dombret H, Seymour JF, Butrym A, Wierzbowska A, Selleslag D, Jang JH et al. Results of a Phase 3, Multicenter, Randomised, Open-label Study of Azacitidine (AZA) vs. conventional Care Regimens (CCR) in Older Patients with Newly Diagnosed Acute Myeloid Leukaemia (AML). Haematologica 2014; 99(s1): 788 (abstract LB2433).
-
(2014)
Haematologica
, vol.99
, Issue.S1
, pp. 788
-
-
Dombret, H.1
Seymour, J.F.2
Butrym, A.3
Wierzbowska, A.4
Selleslag, D.5
Jang, J.H.6
-
8
-
-
84864063679
-
Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
-
Kantarjian HM, Thomas XG, Dmoszynska A, Wierzbowska A, Mazur G, Mayer J et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol 2012; 30 (21): 2670-2677.
-
(2012)
J Clin Oncol
, vol.30
, Issue.21
, pp. 2670-2677
-
-
Kantarjian, H.M.1
Thomas, X.G.2
Dmoszynska, A.3
Wierzbowska, A.4
Mazur, G.5
Mayer, J.6
-
9
-
-
0026000303
-
Nucleosides and nucleotides: 100. 2'-C-cyano-2'-deoxy-1-arabinofuranosylcytosine (CNDAC): Design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside
-
Matsuda J, Nakajima Y, Azuma A, Tanaka M, Sasaki T. Nucleosides and nucleotides: 100. 2'-C-cyano-2'-deoxy-1-arabinofuranosylcytosine (CNDAC): Design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside. J Med Chem 1991; 34: 2917-2919.
-
(1991)
J Med Chem
, vol.34
, pp. 2917-2919
-
-
Matsuda, J.1
Nakajima, Y.2
Azuma, A.3
Tanaka, M.4
Sasaki, T.5
-
10
-
-
0034744725
-
2'-C-cyano-2-deoxy-D-arabinopentafuranosyl cytosine: A novel anticancer nucleoside analog that causes both DNA strand breaks and G2 arrest
-
Azuma A, Huang P, Matsuda A, Plunkett W. 2'-C-cyano-2-deoxy-D-arabinopentafuranosyl cytosine: A novel anticancer nucleoside analog that causes both DNA strand breaks and G2 arrest. Mol Pharmacol 2001; 59: 725-731.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 725-731
-
-
Azuma, A.1
Huang, P.2
Matsuda, A.3
Plunkett, W.4
-
11
-
-
34548329524
-
Antiproliferative effects of sapacitabine (CYC682), a novel2'-deoxycytidinederivative, in human cancer cells
-
Serova M, Galmarini CM, Ghoul A, Benhadji K, Green SR, Chiao J et al. Antiproliferative effects of sapacitabine (CYC682), a novel2'-deoxycytidinederivative, in human cancer cells. Br J Cancer 2007; 97: 628-636.
-
(2007)
Br J Cancer
, vol.97
, pp. 628-636
-
-
Serova, M.1
Galmarini, C.M.2
Ghoul, A.3
Benhadji, K.4
Green, S.R.5
Chiao, J.6
-
12
-
-
0141481272
-
Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer
-
Katz MH, Bouvet M, Takimoto S, Spivack D, Moossa AR, Hoffman RM. Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. Cancer Res 2003; 63: 5521-5525.
-
(2003)
Cancer Res
, vol.63
, pp. 5521-5525
-
-
Katz, M.H.1
Bouvet, M.2
Takimoto, S.3
Spivack, D.4
Moossa, A.R.5
Hoffman, R.M.6
-
13
-
-
74949124273
-
Phase i clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome
-
Kantarjian H, Garcia-Manero G, O'Brien S, Faderl S, Ravandi F, Westwood R et al. Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome. J Clin Oncol 2010; 28: 285-291.
-
(2010)
J Clin Oncol
, vol.28
, pp. 285-291
-
-
Kantarjian, H.1
Garcia-Manero, G.2
O'brien, S.3
Faderl, S.4
Ravandi, F.5
Westwood, R.6
-
14
-
-
84868093252
-
Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: A randomised phase 2 study
-
Kantarjian H, Faderl S, Garcia-Manero G, Luger S, Venugopal P, Maness L et al. Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: A randomised phase 2 study. Lancet Oncol 2012; 13: 1096-1104.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1096-1104
-
-
Kantarjian, H.1
Faderl, S.2
Garcia-Manero, G.3
Luger, S.4
Venugopal, P.5
Maness, L.6
-
15
-
-
80052420105
-
Applicability of a Pick a Winner' trial design to acute myeloid leukemia
-
Hills RK, Burnett AK. Applicability of a Pick a Winner' trial design to acute myeloid leukemia. Blood 2011; 118: 2389-2394.
-
(2011)
Blood
, vol.118
, pp. 2389-2394
-
-
Hills, R.K.1
Burnett, A.K.2
-
16
-
-
39649115845
-
Hematopoietic cell transplantation-specific comorbidity index as an outcome predictor for patients with acute myeloid leukemia in first remission: Combined FHCRC and MDACC experiences
-
Sorror ML, Giralt S, Sandmaier BM, de Lima M, Shahjahan M, Maloney DG et al. Hematopoietic cell transplantation-specific comorbidity index as an outcome predictor for patients with acute myeloid leukemia in first remission: combined FHCRC and MDACC experiences. Blood 2007; 110: 4606-4613.
-
(2007)
Blood
, vol.110
, pp. 4606-4613
-
-
Sorror, M.L.1
Giralt, S.2
Sandmaier, B.M.3
De Lima, M.4
Shahjahan, M.5
Maloney, D.G.6
-
17
-
-
64149100530
-
Prognostic factor analysis of the survival of elderly patients with AML in the MRC AML11 and LRF AML14 trials
-
Wheatley K, Brookes CL, Howman AJ, Goldstone AH, Milligan DW, Prentice AG et al. Prognostic factor analysis of the survival of elderly patients with AML in the MRC AML11 and LRF AML14 trials. Br J Haematol 2009; 145: 598-605.
-
(2009)
Br J Haematol
, vol.145
, pp. 598-605
-
-
Wheatley, K.1
Brookes, C.L.2
Howman, A.J.3
Goldstone, A.H.4
Milligan, D.W.5
Prentice, A.G.6
-
18
-
-
1542753559
-
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
-
Cheson BD, Bennett JM, Kopecky KJ, Büchner T, Willman CL, Estey EH et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J Clin Oncol 2003; 21: 4642-4649.
-
(2003)
J Clin Oncol
, vol.21
, pp. 4642-4649
-
-
Cheson, B.D.1
Bennett, J.M.2
Kopecky, K.J.3
Büchner, T.4
Willman, C.L.5
Estey, E.H.6
-
19
-
-
33644521267
-
Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: Predictive prognostic models for outcome
-
Kantarjian H, O'Brien S, Cortes J, Giles F, Faderl S, Jabbour E et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome. Cancer 2006; 106: 1090-1098.
-
(2006)
Cancer
, vol.106
, pp. 1090-1098
-
-
Kantarjian, H.1
O'Brien, S.2
Cortes, J.3
Giles, F.4
Faderl, S.5
Jabbour, E.6
-
20
-
-
33646404606
-
Age and acute myeloid leukemia
-
Appelbaum FR, Gundacker H, Head DR, Slovak ML, Willman CL, Godwin JE et al. Age and acute myeloid leukemia. Blood 2006; 107: 3481-3485.
-
(2006)
Blood
, vol.107
, pp. 3481-3485
-
-
Appelbaum, F.R.1
Gundacker, H.2
Head, D.R.3
Slovak, M.L.4
Willman, C.L.5
Godwin, J.E.6
-
21
-
-
78649486856
-
Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia
-
Kantarjian H, Ravandi F, O'Brien S, Cortes J, Faderl S, Garcia-Manero G et al. Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia. Blood 2010; 116: 4422-4429.
-
(2010)
Blood
, vol.116
, pp. 4422-4429
-
-
Kantarjian, H.1
Ravandi, F.2
O'Brien, S.3
Cortes, J.4
Faderl, S.5
Garcia-Manero, G.6
-
22
-
-
64149090188
-
The impact of dose escalation and resistance modulation in older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome: The results of the LRF AML14 trial
-
Burnett AK, Milligan D, Goldstone A, Prentice A, McMullin MF, Dennis M et al. The impact of dose escalation and resistance modulation in older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome: the results of the LRF AML14 trial. Br J Haematol 2009; 145: 318-332.
-
(2009)
Br J Haematol
, vol.145
, pp. 318-332
-
-
Burnett, A.K.1
Milligan, D.2
Goldstone, A.3
Prentice, A.4
McMullin, M.F.5
Dennis, M.6
-
23
-
-
78650171819
-
Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: A web-based application for prediction of outcomes
-
Krug U, Rollig C, Koschmieder A, Heinecke A, Sauerland MC, Schaich M et al. Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: A web-based application for prediction of outcomes. Lancet 2010; 376: 2000-2008.
-
(2010)
Lancet
, vol.376
, pp. 2000-2008
-
-
Krug, U.1
Rollig, C.2
Koschmieder, A.3
Heinecke, A.4
Sauerland, M.C.5
Schaich, M.6
-
24
-
-
33644985390
-
Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survival
-
Juliusson G, Billstrom R, Gruber A, Hellström-Lindberg E, Höglunds M, Karlsson K et al. Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survival. Leukemia 2006; 20: 42-47.
-
(2006)
Leukemia
, vol.20
, pp. 42-47
-
-
Juliusson, G.1
Billstrom, R.2
Gruber, A.3
Hellström-Lindberg, E.4
Höglunds, M.5
Karlsson, K.6
-
25
-
-
0022873032
-
A critical appraisal of low-dose cytosine arabinoside in patients with acute non-lymphocytic leukemia and myelodysplastic syndromes
-
Cheson BD, Japerse DM, Simon R, Friedman MA. A critical appraisal of low-dose cytosine arabinoside in patients with acute non-lymphocytic leukemia and myelodysplastic syndromes. J Clin Oncol 4: 1857-18641986.
-
J Clin Oncol
, vol.4
, pp. 1857-18641986
-
-
Cheson, B.D.1
Japerse, D.M.2
Simon, R.3
Friedman, M.A.4
-
26
-
-
0025138479
-
Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly
-
Tilly H, Castaigne S, Bordessoule D, Casassus P, Le Prisé PY, Tertian G et al. Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly. J Clin Oncol 1990; 8: 272-279.
-
(1990)
J Clin Oncol
, vol.8
, pp. 272-279
-
-
Tilly, H.1
Castaigne, S.2
Bordessoule, D.3
Casassus, P.4
Le Prisé, P.Y.5
Tertian, G.6
-
27
-
-
33947205565
-
A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment
-
Burnett AK, Milligan D, Prentice AG, Goldstone AH, McMullin MF, Hills RK et al. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer 2007; 109: 1114-1124.
-
(2007)
Cancer
, vol.109
, pp. 1114-1124
-
-
Burnett, A.K.1
Milligan, D.2
Prentice, A.G.3
Goldstone, A.H.4
McMullin, M.F.5
Hills, R.K.6
-
28
-
-
84873409057
-
The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: Results from the LRF AML14 and NCRI AML16 pick-a-winner comparison
-
Burnett AK, Hills RK, Hunter AE, Milligan D, Kell WJ, Wheatley K et al. The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-a-winner comparison. Leukemia 2013; 27: 75-81.
-
(2013)
Leukemia
, vol.27
, pp. 75-81
-
-
Burnett, A.K.1
Hills, R.K.2
Hunter, A.E.3
Milligan, D.4
Kell, W.J.5
Wheatley, K.6
-
29
-
-
84930572312
-
Phase I/II study of Sapacitabine and Decitabine administered sequentially in elderly patients with newly diagnosed AML. Abstract # 81934
-
Ravandi F, Faderl S, Cortes J, Garcia-Manero G, Jabbour E, Boone PA et al. Phase I/II study of Sapacitabine and Decitabine administered sequentially in elderly patients with newly diagnosed AML. Abstract #81934. ASCO Annual Meeting 2011.
-
(2011)
ASCO Annual Meeting
-
-
Ravandi, F.1
Faderl, S.2
Cortes, J.3
Garcia-Manero, G.4
Jabbour, E.5
Boone, P.A.6
|