Egg-adaptive mutations in H3N2v vaccine virus enhance egg-based production without loss of antigenicity or immunogenicity

Vaccine

Volumn 33, Issue 28, 2015, Pages 3186-3192

  Barman, Subrata ^a   Franks, John ^a   Turner, Jasmine C ^a   Yoon, Sun Woo ^a,b   Webster, Robert G ^a   Webby, Richard J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Antigenicity; Egg adaptation; Hemagglutinin H3 mutations; Immunogenicity; Influenza A virus; Vaccine virus; Variant virus; Zoonosis

Indexed keywords

INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; VIRUS PROTEIN; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; EGG; FERRET; GENETIC STABILITY; HEMAGGLUTINATION; HEMAGGLUTINATION INHIBITION; IMMUNOGENICITY; INFLUENZA VIRUS A H3N2; MALE; MDCK CELL LINE; NONHUMAN; PRIORITY JOURNAL; REVERSE GENETICS; VACCINE PRODUCTION; VIRAL GENETICS; VIROGENESIS; VIRUS REPLICATION; ADAPTATION; AMINO ACID SUBSTITUTION; ANIMAL; CHICK EMBRYO; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; IMMUNOLOGY; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H3N2); METABOLISM; MUTATION; PIG; VIRUS CULTURE;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, VIRAL; CHICK EMBRYO; FERRETS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; MALE; MUTATION; SERIAL PASSAGE; SWINE; VIRUS CULTIVATION; VIRUS REPLICATION;

EID: 84930570657     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.05.011     Document Type: Article

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