Freezing of gait: A practical approach to management

The Lancet Neurology

Volumn 14, Issue 7, 2015, Pages 768-778

  Nonnekes, Jorik ^a   Snijders, Anke H ^a   Nutt, John G ^b   Deuschl, Günter ^c   Giladi, Nir ^d   Bloem, Bastiaan R ^a  

^a RADBOUD UNIVERSITY   (Netherlands)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF KIEL   (Germany)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARKINSON AGENT; CHOLINESTERASE INHIBITOR; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; DOPAMINE AGENTS;

ADL DISABILITY; ALGORITHM; ANAMNESIS; BRADYKINESIA; CLINICAL ASSESSMENT; CONTROLLED CLINICAL TRIAL (TOPIC); CONTROLLED RELEASE FORMULATION; DOPAMINE INDUCED FREEZING OF GAIT; DOPAMINE RESISTANT FREEZING OF GAIT; DOPAMINE RESPONSIVE FREEZING OF GAIT; FREEZING GAIT; GAIT DISORDER; HUMAN; JOB EXPERIENCE; MOTOR PERFORMANCE; NOCTURIA; NOTE; OCCUPATIONAL THERAPIST; OCCUPATIONAL THERAPY; PARKINSONISM; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PHYSIOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT RESPONSE; WALKER; WALKING AID; WHEELCHAIR; DEEP BRAIN STIMULATION; DISEASE MANAGEMENT; GAIT DISORDERS, NEUROLOGIC; HUMANS; METHODS; PHYSICAL THERAPY MODALITIES;

DEEP BRAIN STIMULATION; DISEASE MANAGEMENT; DOPAMINE AGENTS; GAIT DISORDERS, NEUROLOGIC; HUMANS; PHYSICAL THERAPY MODALITIES;

EID: 84930538008     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(15)00041-1     Document Type: Note

References (108)

1. Macht M, Kaussner Y, Moller JC, et al. Predictors of freezing in Parkinson's disease: a survey of 6,620 patients. Mov Disord 2007, 22:953-956.
2. Giladi N, McDermott MP, Fahn S, et al. Freezing of gait in PD-prospective assessment in the DATATOP cohort. Neurology 2001, 56:1712-1721.
3. Almeida QJ, Wishart LR, Lee TD Bimanual coordination deficits with Parkinson's disease: the influence of movement speed and external cueing. Mov Disord 2002, 17:30-37.
4. Nieuwboer A, Vercruysse S, Feys P, Levin O, Spildooren J, Swinnen S Upper limb movement interruptions are correlated to freezing of gait in Parkinson's disease. Eur Neurosci 2009, 29:1422-1430.
5. Moreau C, Ozsancak C, Blatt JL, Derambure P, Destee A, Defebvre L Oral festination in Parkinson's disease: biomechanical analysis and correlation with festination and freezing of gait. Mov Disord 2007, 22:1503-1536.
6. Nutt JG, Bloem BR, Giladi N, Hallett M, Horak FB, Nieuwboer A Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol 2011, 10:734-744.
7. Okuma Y Practical approach to freezing of gait in Parkinson's disease. Pract Neurol 2014, 14:222-230.
8. Canning CG, Paul SS, Nieuwboer A Prevention of falls in Parkinson's disease: a review of fall risk factors and the role of physical interventions. Neurodegener Dis Manag 2014, 4:203-221.
9. Bloem BR, Hausdorff JM, Visser JE, Giladi N Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena. Mov Disord 2004, 19:871-884.
10. Giladi N, Huber-Mahlin V, Herman T, Hausdorff JM Freezing of gait in older adults with high level gait disorders: association with impaired executive function. J Neural Transm 2007, 114:1349-1353.
11. Schaafsma JD, Balash Y, Gurevich T, Bartels AL, Hausdorff JM, Giladi N Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease. Eur J Neurol 2003, 10:391-398.
12. Fahn S, Oakes D, Shoulson I, et al. Levodopa and the progression of Parkinson's disease. N Engl J Med 2004, 351:2498-2508.
13. Fahn S Does levodopa slow or hasten the rate of progression of Parkinson's disease?. J Neurol 2005, 252(suppl 4):IV37-IV42.
14. Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE, Lang AE A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. 056 Study Group. N Engl J Med 2000, 342:1484-1491.
15. Giladi N, Mcdermott MP, Fahn S, et al. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology 2001, 56:1712-1721.
16. Rascol O, Brooks DJ, Melamed E, et al. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial. Lancet 2005, 365:947-954.
17. Vercruysse S, Vandenberghe W, Munks L, Nuttin B, Devos H, Nieuwboer A Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease: a prospective controlled study. J Neurol Neurosurg Psychiatry 2014, 85:871-877.
18. Rochester L, Chastin SF, Lord S, Baker K, Burn DJ Understanding the impact of deep brain stimulation on ambulatory activity in advanced Parkinson's disease. J Neurol 2012, 259:1081-1086.
19. Moreau C, Delval A, Defebvre L, et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol 2012, 11:589-596.
20. Espay AJ, Dwivedi AK, Payne M, et al. Methylphenidate for gait impairment in Parkinson disease: a randomized clinical trial. Neurology 2011, 76:1256-1262.
21. Devos D, French DSG Patient profile, indications, efficacy and safety of duodenal levodopa infusion in advanced Parkinson's disease. Mov Disord 2009, 24:993-1000.
22. Lee JY, Oh S, Kim JM, et al. Intravenous amantadine on freezing of gait in Parkinson's disease: a randomized controlled trial. J Neurol 2013, 260:3030-3038.
23. Giladi N, Treves TA, Simon ES, et al. Freezing of gait in patients with advanced Parkinson's disease. J Neural Transm 2001, 108:53-61.
24. Macht M, Kaussner Y, Moller JC, et al. Predictors of freezing in Parkinson's disease: a survey of 6,620 patients. Mov Disord 2007, 22:953-956.
25. Malkani R, Zadikoff C, Melen O, Videnovic A, Borushko E, Simuni T Amantadine for freezing of gait in patients with Parkinson disease. Clin Neuropharmacol 2012, 35:266-268.
26. Pintor LP, Valldeoriola F, Fernandez-Egea E, et al. Use of electroconvulsive therapy in Parkinson disease with residual axial symptoms partially unresponsive to L-Dopa a pilot study. J ECT 2012, 28:87-91.
27. Valentino F, Cosentino G, Brighina F, et al. Transcranial direct current stimulation for treatment of freezing of gait: a cross-over study. Mov Disord 2014, 29:1064-1069.
28. Moro E, Hamani C, Poon YY, et al. Unilateral pedunculopontine stimulation improves falls in Parkinson's disease. Brain 2010, 133:215-224.
29. Ferraye MU, Debu B, Fraix V, et al. Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease. Brain 2010, 133:205-214.
30. Thevathasan W, Cole MH, Graepel CL, et al. A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation. Brain 2012, 135:1446-1454.
31. Wieler M, Camicioli R, Jones CA, Martin WR Botulinum toxin injections do not improve freezing of gait in Parkinson disease. Neurology 2005, 65:626-628.
32. Fernandez HH, Lannon MC, Trieschmann ME, Friedman JH Botulinum toxin type B for gait freezing in Parkinson's disease. Med Sci Monit 2004, 10:CR282-CR284.
33. Gurevich T, Peretz C, Moore O, Weizmann N, Giladi N The effect of injecting botulinum toxin type A into the calf muscles on freezing of gait in Parkinson's disease: a double blind placebo-controlled pilot study. Mov Disord 2007, 22:880-883.
34. Fukada K, Endo T, Yokoe M, Hamasaki T, Hazama T, Sakoda S L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson's disease. Med Hypotheses 2013, 80:209-212.
35. Chang FC, Tsui DS, Mahant N, et al. 24 h Levodopa-carbidopa intestinal gel may reduce falls and "unresponsive" freezing of gait in Parkinson's disease. Parkinsonism Relat Disord 2015, 21:317-320.
36. Bronstein JM, Tagliati M, Alterman RL, et al. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol 2011, 68:165.
37. Charles PD, Van BN, Krack P, et al. Predictors of effective bilateral subthalamic nucleus stimulation for PD. Neurology 2002, 59:932-934.
38. Kim YE, Yun JY, Yang HJ, et al. Intravenous amantadine for freezing of gait resistant to dopaminergic therapy: a randomized, double-blind, placebo-controlled, cross-over clinical trial. PLoS One 2012, 7:e48890.
39. Espay AJ, Fasano A, van Nuenen BF, Payne MM, Snijders AH, Bloem BR "On" state freezing of gait in Parkinson disease: a paradoxical levodopa-induced complication. Neurology 2012, 78:454-457.
40. Ferraye MU, Debu B, Fraix V, et al. Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease. Neurology 2008, 70:1431-1437.
41. Keus SH, Bloem BR, Hendriks EJ, Bredero-Cohen AB, Munneke M Evidence-based analysis of physical therapy in Parkinson's disease with recommendations for practice and research. Mov Disord 2007, 22:451-460.
42. Keus SH, Munneke M, Nijkrake MJ, Kwakkel G, Bloem BR Physical therapy in Parkinson's disease: evolution and future challenges. Mov Disord 2009, 24:1-14.
43. Nieuwboer A Cueing for freezing of gait in patients with Parkinson's disease: a rehabilitation perspective. Mov Disord 2008, 23(suppl 2):S475-S481.
44. Morris ME, Martin CL, Schenkman ML Striding out with Parkinson disease: evidence-based physical therapy for gait disorders. Phys Ther 2010, 90:280-288.
45. Donovan S, Lim C, Diaz N, et al. Laserlight cues for gait freezing in Parkinson's disease: an open-label study. Parkinsonism Relat Disord 2011, 17:240-245.
46. Ingrid HWM, Sturkenboom SHJK, Munneke M, Bloem BR Physical therapy and occupational therapy in Parkinson's disease. Handbook of Parkinson's disease 2013, CRC press, Boca Raton, FL. fifth edition.
47. Snijders AH, Nijkrake MJ, Bakker M, Munneke M, Wind C, Bloem BR Clinimetrics of freezing of gait. Mov Disord 2008, 23:S468-S474.
48. Snijders AH, Haaxma CA, Hagen YJ, Munneke M, Bloem BR Freezer or non-freezer: clinical assessment of freezing of gait. Parkinsonism Relat Disord 2012, 18:149-154.
49. Nieuwboer A, Rochester L, Herman T, et al. Reliability of the new freezing of gait questionnaire: agreement between patients with Parkinson's disease and their carers. Gait Posture 2009, 30:459-463.
50. Nonnekes J, Janssen AM, Mensink SH, Oude Nijhuis LB, Bloem BR, Snijders AH Short rapid steps to provoke freezing of gait in Parkinson's disease. J Neurol 2014, 261:1763-1767.
51. Nieuwboer A Cueing for freezing of gait in patients with Parkinson's disease: a rehabilitation perspective. Mov Disord 2008, 23(suppl 2):S475-S481.
52. Snijders AH, Toni I, Ruzicka E, Bloem BR Bicycling breaks the ice for freezers of gait. Mov Disord 2011, 26:367-371.
53. Miwa H, Kondo T Bicycle sign for differential diagnosis of Parkinsonism: is it of use in a hilly country like Japan?. J Parkinsons Dis 2011, 1:167-168.
54. Giladi N, McDermott MP, Fahn S, et al. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology 2001, 56:1712-1721.
55. Connolly BS, Lang AE Pharmacological treatment of Parkinson disease: a review. JAMA 2014, 311:1670-1683.
56. Bakker M, Esselink RA, Munneke M, Limousin-Dowsey P, Speelman HD, Bloem BR Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease. Mov Disord 2004, 19:1092-1099.
57. Stolze H, Klebe S, Poepping M, et al. Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait. Neurology 2001, 57:144-146.
58. Xie J, Krack P, Benabid AL, Pollak P Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait. J Neurol 2001, 248:1068-1072.
59. Faist M, Xie J, Kurz D, et al. Effect of bilateral subthalamic nucleus stimulation on gait in Parkinson's disease. Brain 2001, 124:1590-1600.
60. Lubik S, Fogel W, Tronnier V, Krause M, Konig J, Jost WH Gait analysis in patients with advanced Parkinson disease: different or additive effects on gait induced by levodopa and chronic STN stimulation. J Neural Transm 2006, 113:163-173.
61. Allert N, Volkmann J, Dotse S, Hefter H, Sturm V, Freund HJ Effects of bilateral pallidal or subthalamic stimulation on gait in advanced Parkinson's disease. Mov Disord 2001, 16:1076-1085.
62. Piper M, Abrams GM, Marks WJ Deep brain stimulation for the treatment of Parkinson's disease: overview and impact on gait and mobility. Neuro Rehabilitation 2005, 20:223-232.
63. Defebvre LJ, Krystkowiak P, Blatt JL, et al. Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease. Mov Disord 2002, 17:76-83.
64. St George RJ, Nutt JG, Burchiel KJ, Horak FB A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD. Neurology 2010, 75:1292-1299.
65. Moro E, Lozano AM, Pollak P, et al. Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease. Mov Disord 2010, 25:578-586.
66. Follett KA, Weaver FM, Stern M, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med 2010, 362:2077-2091.
67. Schrader C, Capelle HH, Kinfe TM, et al. GPi-DBS may induce a hypokinetic gait disorder with freezing of gait in patients with dystonia. Neurology 2011, 77:483-488.
68. van Nuenen BF, Esselink RA, Munneke M, Speelman JD, van Laar T, Bloem BR Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson's disease. Mov Disord 2008, 23:2404-2406.
69. Krack P, Batir A, Van Blercom N, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 2003, 349:1925-1934.
70. Fasano A, Aquino CC, Krauss JK, Honey CR, Bloem BR Axial disability and deep brain stimulation in patients with Parkinson disease. Nat Rev Neurol 2015, 11:98-110.
71. Moreau C, Defebvre L, Destee A, et al. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology 2008, 71:80-84.
72. Ricchi V, Zibetti M, Angrisano S, et al. Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: a 15 months follow-up study. Brain Stimul 2012, 5:388-392.
73. Fasano A, Daniele A, Albanese A Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation. Lancet Neurol 2012, 11:429-442.
74. Xie T, Vigil J, MacCracken E, et al. Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD. Neurology 2015, 84:415-420.
75. Annic A, Moreau C, Salleron J, et al. Predictive factors for improvement of gait by low-frequency stimulation in Parkinson's disease. J Parkinsons Dis 2014, 4:413-420.
76. Fasano A, Herzog J, Seifert E, et al. Modulation of gait coordination by subthalamic stimulation improves freezing of gait. Mov Disord 2011, 26:844-851.
77. Hauser RA, Hsu A, Kell S, et al. Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson's disease and motor fluctuations: a phase 3 randomised, double-blind trial. Lancet Neurol 2013, 12:346-356.
78. Wright BA, Waters CH Continuous dopaminergic delivery to minimize motor complications in Parkinson's disease. Expert Rev Neurother 2013, 13:719-729.
79. Grimbergen YA, Langston JW, Roos RA, Bloem BR Postural instability in Parkinson's disease: the adrenergic hypothesis and the locus coeruleus. Expert Rev Neurother 2009, 9:279-290.
80. Bohnen NI, Frey KA, Studenski S, et al. Extra-nigral pathological conditions are common in Parkinson's disease with freezing of gait: an in vivo positron emission tomography study. Mov Disord 2014, 29:1118-1124.
81. Chung KA, Lobb BM, Nutt JG, Horak FB Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease. Neurology 2010, 75:1263-1269.
82. Alam M, Schwabe K, Krauss JK The pedunculopontine nucleus area: critical evaluation of interspecies differences relevant for its use as a target for deep brain stimulation. Brain 2011, 134:11-23.
83. van Gilst MM, Bloem BR, Overeem S "Sleep benefit" in Parkinson's disease: a systematic review. Parkinsonism Relat Disord 2013, 19:654-659.
84. van Gilst MM, van Mierlo P, Bloem BR, Overeem S Quantitative motor performance and sleep benefit in Parkinson disease. Sleep 2015, sp-00507-14.
85. Cools R Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease. Neurosci Biobehav Rev 2006, 30:1-23.
86. Cubo E, Moore CG, Leurgans S, Goetz CG Wheeled and standard walkers in Parkinson's disease patients with gait freezing. Parkinsonism Relat Disord 2003, 10:9-14.
87. Keus SH, Graziona M European physiotherapy guideline for Parkinson's disease 2014, on behalf of the Guideline Development Group, ParkinsonNet, The Netherlands. http://parkinsonnet.info/guidelines/european-guidelines.
88. Sturkenboom IH, Thijssen MC, Gons-van de Elsacker JJ, et al. Guidelines for occupational therapy in Parkinson's disease rehabilitation 2008, ParkinsonNet, The Netherlands. http://www.parkinsonnet.info/media/14820461/ot_guidelines_final-npf__3_.pdf.
89. Bloem BR, Munneke M Revolutionising management of chronic disease: the ParkinsonNet approach. BMJ 2014, 348:g1838.
90. Munneke M, Nijkrake MJ, Keus SH, et al. Efficacy of community-based physiotherapy networks for patients with Parkinson's disease: a cluster-randomised trial. Lancet Neurol 2010, 9:46-54.
91. Sturkenboom IH, Graff MJ, Hendriks JC, et al. Efficacy of occupational therapy for patients with Parkinson's disease: a randomised controlled trial. Lancet Neurol 2014, 13:557-566.
92. Morgante F, Fasano A Improvement with duloxetine in primary progressive freezing gait. Neurology 2010, 75:2130-2132.
93. Armstrong RA Visual symptoms in Parkinson's disease. Parkinsons Dis 2011, 2011:908306.
94. Bloem BR, Overeem S, Van Dijk JG Syncopal falls, drop attacks and their mimics. Clinical disorders of balance, posture and gait 2004, 286-316. Arnold, London. A.M. Bronstein, T. Brandt, J.G. Nutt, M.H. Woollacott (Eds.).
95. Kondo T Drug intervention for freezing of gait to dopaminergic therapy: a pilot resistant study. Parkinsonism Relat Disord 2006, 12:S63-S66.
96. Wenning GK Placebo-controlled trial of amantadine in multiple-system atrophy. Clin Neuropharmacol 2005, 28:225-227. Working Group on Atypical Parkinsonism of the Austrian Parkinson's Society.
97. Newman GC Treatment of progressive supranuclear palsy with tricyclic antidepressants. Neurology 1985, 35:1189-1193.
98. Engel PA Treatment of progressive supranuclear palsy with amitriptyline: therapeutic and toxic effects. J Am Geriatr Soc 1996, 44:1072-1074.
99. Yamamoto M, Fujii S, Hatanaka Y Result of long-term administration of L-threo-3,4-dihydroxyphenylserine in patients with pure akinesia as an early symptom of progressive supranuclear palsy. Clin Neuropharmacol 1997, 20:371-373.
100. Shih LC, Tarsy D Deep brain stimulation for the treatment of atypical parkinsonism. Mov Disord 2007, 22:2149-2155.
101. Grimbergen YA, Speelman AD, van der Marck MA, Bloem BR Gait, postural instability, and freezing. Parkinson's disease: non-motor and non-dopaminergic features 2011, 361-373. Wiley-Blackwell, Hoboken, New Jersey. C.W. Olanow, F. Stocchi, A.E. Lang (Eds.).
102. Mahabier SW, Snijders AH, Delval A, Bloem BR Freezing of gait. Encyclopedia of movement disorders 2010, 486-491. Academic Press, Oxford. K. Kompoliti, L. Verhagen Metman (Eds.).
103. Spildooren J, Vercruysse S, Desloovere K, Vandenberghe W, Kerckhofs E, Nieuwboer A Freezing of gait in Parkinson's disease: the impact of dual-tasking and turning. Mov Disord 2010, 25:2563-2570.
104. Moore ST, Yungher DA, Morris TR, et al. Autonomous identification of freezing of gait in Parkinson's disease from lower-body segmental accelerometry. J Neuroeng Rehabil 2013, 10:19.
105. Weiss A, Herman T, Giladi N, Hausdorff JM New evidence for gait abnormalities among Parkinson's disease patients who suffer from freezing of gait: insights using a body-fixed sensor worn for 3 days. J Neural Transm 2014, 122:403-410.
106. Cole BT, Roy SH, Nawab SH Detecting freezing-of-gait during unscripted and unconstrained activity. Conf Proc IEEE Eng Med Biol Soc 2011, 2011:5649-5652.
107. Maetzler W, Domingos J, Srulijes K, Ferreira JJ, Bloem BR Quantitative wearable sensors for objective assessment of Parkinson's disease. Mov Disord 2013, 28:1628-1637.
108. Ferraye MU, Debu B, Fraix V, et al. Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease. Neurology 2008, 70:1431-1437.