Elective single versus double embryo transfer: Live birth outcome and patient acceptance in a prospective randomised trial

Reproduction, Fertility and Development

Volumn 27, Issue 5, 2015, Pages 794-800

  Prados, Nicolas ^a,b   Quiroga, Rocio ^a   Caligara, Cinzia ^a   Ruiz, Myriam ^a   Blasco, Victor ^a   Pellicer, Antonio ^c,d   Fernandez Sanchez, Manuel ^a,b  

^a INSTITUTO VALENCIANO DE INFERTILIDAD   (Spain)

^b UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Delivery rate; multiple birth rate; multiple pregnancy.

Indexed keywords

ADULT; ARTICLE; BLASTOCYST; CONTROLLED STUDY; DELIVERY; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; INTERMETHOD COMPARISON; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; MAJOR CLINICAL STUDY; MULTIPLE PREGNANCY; NIDATION; PATIENT ATTITUDE; PREGNANCY OUTCOME; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; BIRTH RATE; IN VITRO FERTILIZATION; MATERNAL AGE; PREGNANCY; PROCEDURES; PROSPECTIVE STUDY; SINGLE EMBRYO TRANSFER; TREATMENT OUTCOME;

ADULT; BIRTH RATE; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMANS; LIVE BIRTH; MATERNAL AGE; PATIENT ACCEPTANCE OF HEALTH CARE; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; PREGNANCY, MULTIPLE; PROSPECTIVE STUDIES; SINGLE EMBRYO TRANSFER; TREATMENT OUTCOME;

EID: 84930515143     PISSN: 10313613     EISSN: 14485990     Source Type: Journal    
DOI: 10.1071/RD13412     Document Type: Article

References (33)

1. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology (2011). The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Reprod. Biomed. Online 22, 632-646.
2. Behr, B., Fisch, J. D., Racowsky, C., Miller, K., Pool, T. B., and Milki, A. A. (2000). Blastocyst-ET and monozygotic twinning. J. Assist. Reprod. Genet. 17, 349-351. doi:10.1023/A:1009461213139
3. Blake, D. A., Farquhar, C. M., Johnson, N., and Proctor, M. (2007). Cleavage stage versus blastocyst stage embryo transfer in assisted conception. Cochrane Database Syst. Rev. 4, CD002118.
4. Blickstein, I., Jones, C., and Keith, L. G. (2003). Zygotic-splitting rates after single-embryo transfers in in vitro fertilization. N. Engl. J. Med. 348, 2366-2367. doi:10.1056/NEJMC026724
5. Cobo, A., Bellver, J., Domingo, J., Perez, S., Crespo, J., Pellicer, A., and Remohi, J. (2008). New options in assisted reproduction technology: the Cryotop method of oocyte vitrification. Reprod. Biomed. Online 17, 68-72. doi:10.1016/S1472-6483(10)60295-7
6. Elgindy, E. A., Abou-Setta, A. M., and Mostafa, M. I. (2011). Blastocyststage versus cleavage-stage embryo transfer in women with high oestradiol concentrations: randomized controlled trial. Reprod. Biomed. Online 23, 789-798. doi:10.1016/J.RBMO.2011.08.011
7. Gerris, J., De Neubourg, D., Mangelschots, K., Van Royen, E., Vercruyssen, M., Barudy-Vasquez, J., Valkenburg, M., and Ryckaert, G. (2002). Elective single Day 3 embryo transfer halves the twinning rate without decrease in the ongoing pregnancy rate of an IVF/ICSI programme. Hum. Reprod. 17, 2626-2631. doi:10.1093/HUMREP/17.10.2626
8. Gleicher, N., Campbell, D. P., Chan, C. L., Karande, V., Rao, R., Balin, M., and Pratt, D. (1995). The desire for multiple births in couples with infertility problems contradicts present practice patterns. Hum. Reprod. 10, 1079-1084.
9. Grobman, W. A., Milad, M. P., Stout, J., and Klock, S. C. (2001). Patient perceptions of multiple gestations: an assessment of knowledge and risk aversion. Am. J. Obstet. Gynecol. 185, 920-924. doi:10.1067/MOB.2001.117305
10. Hope, N., and Rombauts, L. (2010). Can an educational DVD improve the acceptability of elective single embryo transfer A randomized controlled study. Fertil. Steril. 94, 489-495. doi:10.1016/J.FERTNSTERT. 2009.03.080
11. Jacob, S., and Moley, K. H. (2005). Gametes and embryo epigenetic reprogramming affect developmental outcome: implication for assisted reproductive technologies. Pediatr. Res. 58, 437-446. doi:10.1203/01. PDR.0000179401.17161.D3
12. Källén, B., Finnström, O., Lindam, A., Nilsson, E., Nygren, K. G., and Olausson, P. O. (2010). Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome Fertil. Steril. 94, 1680-1683. doi:10.1016/J.FERTNSTERT.2009.12.027
13. Kjellberg, A. T., Carlsson, P., and Bergh, C. (2006). Randomized single versus double embryo transfer: obstetric and paediatric outcome and a cost-effectiveness analysis. Hum. Reprod. 21, 210-216. doi:10.1093/HUMREP/DEI298
14. Kresowik, J. D., Stegmann, B. J., Sparks, A. E., Ryan, G. L., and van Voorhis, B. J. (2011). Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates. Fertil. Steril. 96, 1367-1369. doi:10.1016/J.FERTNSTERT.2011.09.007
15. Lachin, J. M. (2000). Statistical considerations in the intent-to-treat principle. Control. Clin. Trials 21, 167-189. doi:10.1016/S0197-2456(00)00092-1
16. Martin, J. A., and Park, M. M. (1999). Trends in twin and triplet births: 1980-97. Natl Vital Stat. Rep. 47, 1-16.
17. Milki, A. A., Jun, S. H., Hinckley, M. D., Behr, B., Giudice, L. C., and Westphal, L. M. (2003). Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer. Fertil. Steril. 79, 503-506. doi:10.1016/S0015-0282(02)04754-4
18. Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., and Altman, D. G. (2010). CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 340, c869. doi:10.1136/BMJ.C869
19. Mullin, C. M., Fino, M. E., Talebian, S., Krey, L. C., Licciardi, F., and Grifo, J. A. (2010). Comparison of pregnancy outcomes in elective single blastocyst transfer versus double blastocyst transfer stratified by age. Fertil. Steril. 93, 1837-1843. doi:10.1016/J.FERTNSTERT. 2008.12.137
20. Murray, S., Shetty, A., Rattray, A., Taylor, V., and Bhattacharya, S. (2004). A randomized comparison of alternative methods of information provision on the acceptability of elective single embryo transfer. Hum. Reprod. 19, 911-916. doi:10.1093/HUMREP/DEH176
21. Newton, C. R., McBride, J., Feyles, V., Tekpetey, F., and Power, S. (2007). Factors affecting patients' attitudes toward single-and multiple-embryo transfer. Fertil. Steril. 87, 269-278. doi:10.1016/J.FERTNSTERT. 2006.06.043
22. Pandian, Z., Bhattacharya, S., Ozturk, O., Serour, G., and Templeton, A. (2009). Number of embryos for transfer following in-vitro fertilisation or intra-cytoplasmic sperm injection. Cochrane Database Syst. Rev. 2, CD003416.
23. Papanikolaou, E. G., D'Haeseleer, E., Verheyen, G., Van de Velde, H., Camus, M., Van Steirteghem, A., Devroey, P., and Tournaye, H. (2005). Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on Day 3 of embryo culture. A randomized prospective study. Hum. Reprod. 20, 3198-3203. doi:10.1093/HUMREP/DEI217
24. Papanikolaou, E. G., Fatemi, H., Venetis, C., Donoso, P., Kolibianakis, E., Tournaye, H., Tarlatzis, B., and Devroey, P. (2010). Monozygotic twinning is not increased after single blastocyst transfer compared with single cleavage-stage embryo transfer. Fertil. Steril. 93, 592-597. doi:10.1016/J.FERTNSTERT.2008.12.088
25. Porter, M., and Bhattacharya, S. (2005). Investigation of staff and patients' opinions of a proposed trial of elective single embryo transfer. Hum. Reprod. 20, 2523-2530. doi:10.1093/HUMREP/DEI094
26. Rai, V., Betsworth, A., Beer, C., Ndukwe, G., and Glazebrook, C. (2011). Comparing patients' and clinicians' perceptions of elective single embryo transfer using the attitudes to a twin IVF pregnancy scale (ATIPS). J. Assist. Reprod. Genet. 28, 65-72. doi:10.1007/S10815-010-9484-6
27. Ryan, G. L., Sparks, A. E., Sipe, C. S., Syrop, C. H., Dokras, A., and Van Voorhis, B. J. (2007).A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates. Fertil. Steril. 88, 354-360. doi:10.1016/J.FERTNSTERT.2007.03.001
28. Schulz, K. F., Altman, D. G., and Moher, D. (2010). CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. J. Pharmacol. Pharmacother. 1, 100-107. doi:10.4103/0976-500X.72352
29. The ESRHE Capri Workshop Group (2000). Multiple gestation pregnancy. Hum. Reprod. 15, 1856-1864. doi:10.1093/HUMREP/15.8.1856
30. Thurin, A., Hausken, J., Hillensjo, T., Jablonowska, B., Pinborg, A., Strandell, A., and Bergh, C. (2004). Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. N. Engl. J. Med. 351, 2392-2402. doi:10.1056/NEJMOA041032
31. Tsirigotis, M. (1998). Blastocyst stage transfer: pitfalls and benefits. Too soon to abandon current practice Hum. Reprod. 13, 3285-3289. doi:10.1093/HUMREP/13.12.3285
32. van den Akker, O. B., and Purewal, S. (2011). Elective single-embryo transfer: persuasive communication strategies can affect choice in a young British population. Reprod. Biomed. Online 23, 838-850. doi:10.1016/J.RBMO.2011.07.022
33. Zander-Fox, D. L., Tremellen, K., and Lane, M. (2011). Single blastocyst embryo transfer maintains comparable pregnancy rates to double cleavage-stage embryo transfer but results in healthier pregnancy outcomes. Aust. N. Z. J. Obstet. Gynaecol. 51, 406-410. doi:10.1111/J.1479-828X.2011.01324.X