Combined mesenchymal stem cell sheets and rhBMP-2-releasing calcium sulfate-rhBMP-2 scaffolds for segmental bone tissue engineering

Cell Transplantation

Volumn 21, Issue 4, 2012, Pages 693-705

  Qi, Yiying ^a   Wang, Yulu ^b   Yan, Weiqi ^a   Li, Hang ^a   Shi, Zhongli ^a   Pan, Zhijun ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Department of Orthopedic Surgery   (China)

Author keywords

Bone regeneration; Calcium sulfate; Mesenchymal stem cells (MSCs); Osteogenic differentiation; recombinant human bone morphogenetic protein (rhBMP 2)

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM SULFATE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE TISSUE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACTIVITY; EXPERIMENTAL RABBIT; IN VITRO STUDY; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; SCORING SYSTEM; TISSUE ENGINEERING; ULNA; X RAY ANALYSIS;

ORYCTOLAGUS CUNICULUS;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CALCIUM SULFATE; CELLS, CULTURED; HUMANS; MESENCHYMAL STROMAL CELLS; RABBITS; RECOMBINANT PROTEINS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TRANSFORMING GROWTH FACTOR BETA; X-RAY MICROTOMOGRAPHY;

EID: 84930479935     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368911X623844     Document Type: Article

References (44)

1. Aggarwal, S.; Pittenger, M. F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105(4):1815-1822; 2005.
2. Alsberg, E.; Kong, H. J.; Hirano, Y.; Smith, M. K.; Albeiruti, A.; Mooney, D. J. Regulating bone formation via controlled scaffold degradation. J. Dent. Res. 82(11): 903-908; 2003.
3. Bessho, K.; Carnes, D. L.; Cavin, R.; Ong, J. L. Experimental studies on bone induction using low-molecular- weight poly (DL-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2. J. Biomed. Mater. Res. 61(1):61-65; 2002.
4. Borrelli, Jr., J.; Prickett, W. D.; Ricci, W. M. Treatment of nonunions and osseous defects with bone graft and calcium sulfate. Clin. Orthop. Relat. Res. 411:245-254; 2003.
5. Bruder, S. P.; Fox, B. S. Tissue engineering of bone. Cell based strategies. Clin. Orthop. Relat. Res. 367(Suppl.): S68-83; 1999.
6. Chen, F.; Chen, S.; Tao, K.; Feng, X.; Liu, Y.; Lei, D.; Mao, T. Marrow-derived osteoblasts seeded into porous natural coral to prefabricate a vascularised bone graft in the shape of a human mandibular ramus: experimental study in rabbits. Br. J. Oral Maxillofac. Surg. 42(6):532-537; 2004.
7. Cooper, M. L.; Andree, C.; Hansbrough, J. F.; Zapata-Sirvent, R. L.; Spielvogel, R. L. Direct comparison of a cultured composite skin substitute containing human kera- tinocytes and fibroblasts to an epidermal sheet graft containing human keratinocytes on athymic mice. J. Invest. Dermatol. 101(6):811-819; 1993.
8. Dacquet, V.; Varlet, A.; Tandogan, R. N.; Tahon, M. M.; Fournier, L.; Jehl, F.; Monteil, H.; Bascoulergue, G. Antibiotic-impregnated plaster of Paris beads. Trials with tei- coplanin. Clin. Orthop. Relat. Res. 282:241-249; 1992.
9. Damien, C. J.; Parsons, J. R. Bone graft and bone graft substitutes: A review of current technology and applications. J. Appl. Biomater. 2(3):187-208; 1991.
10. Dickens, S. H.; Kelly, S. R.; Flaim, G. M.; Giuseppetti, A. A. Dentin adhesion and microleakage of a resin-based calcium phosphate pulp capping and basing cement. Eur. J. Oral Sci. 112(5):452-457; 2004.
11. Dumas, A.; Moreau, M. F.; Gherardi, R. K.; Basle, M. F.; Chappard, D. Bone grafts cultured with bone marrow stromal cells for the repair of critical bone defects: An experimental study in mice. J. Biomed. Mater. Res. A 90(4): 1218-1229; 2009.
12. Giannoni, P.; Mastrogiacomo, M.; Alini, M.; Pearce, S. G.; Corsi, A.; Santolini, F.; Muraglia, A.; Bianco, P.; Cancedda, R. Regeneration of large bone defects in sheep using bone marrow stromal cells. J. Tissue Eng. Regen. Med. 2(5):253-262; 2008.
13. Gitelis, S.; Piasecki, P.; Turner, T.; Haggard, W.; Charters, J.; Urban, R. Use of a calcium sulfate-based bone graft substitute for benign bone lesions. Orthopedics 24(2): 162-166; 2001.
14. Goldstein, A. S. Effect of seeding osteoprogenitor cells as dense clusters on cell growth and differentiation. Tissue Eng. 7(6):817-827; 2001.
15. Hoshino, M.; Egi, T.; Terai, H.; Namikawa, T.; Kato, M.; Hashimoto, Y.; Takaoka, K. Repair of long intercalated rib defects in dogs using recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate. J. Biomed. Mater. Res. A 90(2):514-521; 2009.
16. Kanczler, J. M.; Ginty, P. J.; White, L.; Clarke, N. M.; Howdle, S. M.; Shakesheff, K. M.; Oreffo, R. O. The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials 31(6):1242-1250; 2010.
17. Kon, E.; Muraglia, A.; Corsi, A.; Bianco, P.; Marcacci, M.; Martin, I.; Boyde, A.; Ruspantini, I.; Chistolini, P.; Rocca, M.; Giardino, R.; Cancedda, R.; Quarto, R. Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical- size defects of sheep long bones. J. Biomed. Mater. Res. 49(3):328-337; 2000.
18. Lane, J. M.; Sandhu, H. S. Current approaches to experimental bone grafting. Orthop. Clin. North Am. 18(2):213-225; 1987.
19. Levenberg, S.; Rouwkema, J.; Macdonald, M.; Garfein, E. S.; Kohane, D. S.; Darland, D. C.; Marini, R.; van Blitterswijk, C.A.; Mulligan, R. C.; D'Amore, P. A.; Langer, R. Engineering vascularized skeletal muscle tissue. Nat. Biotechnol. 23(7):879-884; 2005.
20. Lillo, R.; Peltier, L. F. The substitution of plaster of Paris rods for portions of the diaphysis of the radius in dogs. Surg. Forum 6:556-558; 1956.
21. Mankani, M. H.; Kuznetsov, S. A.; Fowler, B.; Kingman, A.; Robey, P. G. In vivo bone formation by human bone marrow stromal cells: Effect of carrier particle size and shape. Biotechnol. Bioeng. 72(1):96-107; 2001.
22. McKee, M. D.; Wild, L. M.; Schemitsch, E. H.; Waddell, J. P. The use of an antibiotic-impregnated, osteoconduc- tive, bioabsorbable bone substitute in the treatment of infected long bone defects: Early results of a prospective trial. J. Orthop. Trauma 16(9):622-627; 2002.
23. Murphy, W. L.; Simmons, C. A.; Kaigler, D.; Mooney, D. J. Bone regeneration via a mineral substrate and induced angiogenesis. J. Dent. Res. 83(3):204-210; 2004.
24. Nakamura, A.; Akahane, M.; Shigematsu, H.; Tadokoro, M.; Morita, Y.; Ohgushi, H.; Dohi, Y.; Imamura, T.; Tanaka, Y. Cell sheet transplantation of cultured mesenchymal stem cells enhances bone formation in a rat nonunion model. Bone 46(2):418-424; 2010.
25. Nishida, K.; Yamato, M.; Hayashida, Y.; Watanabe, K.; Yamamoto, K.; Adachi, E.; Nagai, S.; Kikuchi, A.; Maeda, N.; Watanabe, H.; Okano, T.; Tano, Y. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N. Engl. J. Med. 351(12):1187-1196; 2004.
26. Ouyang, H. W.; Toh, S. L.; Goh, J.; Tay, T. E.; Moe, K. Assembly of bone marrow stromal cell sheets with knitted poly (L-lactide) scaffold for engineering ligament analogs. J. Biomed. Mater. Res. B Appl. Biomater. 75(2):264-271; 2005.
27. Prockop, D. J. Marrow stromal cells as stem cells for non- hematopoietic tissues. Science 276(5309):71-74; 1997.
28. Rasmusson, I. Immune modulation by mesenchymal stem cells. Exp. Cell Res. 312(12):2169-2179; 2006.
29. Roldan, J. C.; Jepsen, S.; Miller, J.; Freitag, S.; Rueger, D.C.; Acil, Y.; Terheyden, H. Bone formation in the presence of platelet-rich plasma vs. bone morphogenetic protein-7. Bone 34(1):80-90; 2004.
30. Saito, N.; Okada, T.; Horiuchi, H.; Ota, H.; Takahashi, J.; Murakami, N.; Nawata, M.; Kojima, S.; Nozaki, K.; Takaoka, K. Local bone formation by injection of recombinant human bone morphogenetic protein-2 contained in polymer carriers. Bone 32(4):381-386; 2003.
31. Scaglione, S.; Braccini, A.; Wendt, D.; Jaquiery, C.; Beltrame, F.; Quarto, R.; Martin, I. Engineering of osteoinductive grafts by isolation and expansion of ovine bone marrow stromal cells directly on 3D ceramic scaffolds. Biotechnol. Bioeng. 93(1):181-187; 2006.
32. Shimizu, T.; Sekine, H.; Yang, J.; Isoi, Y.; Yamato, M.; Kikuchi, A.; Kobayashi, E.; Okano, T. Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues. FASEB J. 20(6):708-710; 2006.
33. Sun, H.; Wu, C.; Dai, K.; Chang, J.; Tang, T. Proliferation and osteoblastic differentiation of human bone marrow- derived stromal cells on akermanite-bioactive ceramics. Biomaterials 27(33):5651-5657; 2006.
34. Trojani, C.; Boukhechba, F.; Scimeca, J. C.; Vandenbos, F.; Michiels, J. F.; Daculsi, G.; Boileau, P.; Weiss, P.; Carle, G. F.; Rochet, N. Ectopic bone formation using an injectable biphasic calcium phosphate/Si-HPMC hydrogel composite loaded with undifferentiated bone marrow stromal cells. Biomaterials 27(17):3256-3264; 2006.
35. Turner, T. M.; Urban, R. M.; Gitelis, S.; Kuo, K. N.; Andersson, G. B. Radiographic and histologic assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone-graft substitute, a bone- graft expander, and a method for local antibiotic delivery. One institution's experience. J. Bone Joint Surg. Am. 83-A(Suppl. 2):8-18; 2001.
36. Wang, M. L.; Massie, J.; Allen, R. T.; Lee, Y. P.; Kim, C. W. Altered bioreactivity and limited osteoconductivity of calcium sulfate-based bone cements in the osteoporotic rat spine. Spine J. 8(2):340-350; 2008.
37. Wang, W.; Li, B.; Yang, J.; Xin, L.; Li, Y.; Yin, H.; Qi, Y.; Jiang, Y.; Ouyang, H.; Gao, C. The restoration of fullthickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs. Biomaterials 31(34): 8964-8973; 2010.
38. Wozney, J. M.; Rosen, V.; Celeste, A. J.; Mitsock, L. M.; Whitters, M. J.; Kriz, R. W.; Hewick, R. M.; Wang, E. A. Novel regulators of bone formation: Molecular clones and activities. Science 242(4885):1528-1534; 1988.
39. Yagi, H.; Soto-Gutierrez, A.; Parekkadan, B.; Kitagawa, Y.; Tompkins, R. G.; Kobayashi, N.; Yarmush, M. L. Mesenchymal stem cells: Mechanisms of immunomodula- tion and homing. Cell Transplant. 19(6):667-679; 2010.
40. Yamada, Y.; Ito, K.; Nakamura, S.; Ueda, M.; Nagasaka, T. Promising cell-based therapy for bone regeneration using stem cells from deciduous teeth, dental pulp, and bone marrow. Cell Transplant. 20(7):1003-1013; 2011.
41. Yang, J.; Yamato, M.; Kohno, C.; Nishimoto, A.; Sekine, H.; Fukai, F.; Okano, T. Cell sheet engineering: Recreating tissues without biodegradable scaffolds. Biomaterials 26(33):6415-6422; 2005.
42. Zhou, J.; Lin, H.; Fang, T.; Li, X.; Dai, W.; Uemura, T.; Dong, J. The repair of large segmental bone defects in the rabbit with vascularized tissue engineered bone. Biomaterials 31(6):1171-1179; 2010.
43. Zhou, Y.; Chen, F.; Ho, S. T.; Woodruff, M. A.; Lim, T. M.; Hutmacher, D. W. Combined marrow stromal cell- sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts. Biomaterials 28(5):814-824; 2007.
44. Zou, X. H.; Cai, H. X.; Yin, Z.; Chen, X.; Jiang, Y. Z.; Hu, H.; Ouyang, H. W. A novel strategy incorporated the power of mesenchymal stem cells to allografts for segmental bone tissue engineering. Cell Transplant. 18(4): 433-441; 2009.