A case of thrombotic micro-angiopathy after heart transplantation successfully treated with eculizumab

Transplant International

Volumn 28, Issue 7, 2015, Pages 878-880

  Morales, Enrique ^a   Rabasco, Cristina ^a   Gutierrez, Eduardo ^a   Praga, Manuel ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BASILIXIMAB; ECULIZUMAB; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; MYCOPHENOLATE MOFETIL; TACROLIMUS; COMPLEMENT INHIBITOR; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY;

ADULT; ANEMIA; AORTA BALLOON; BLOOD SMEAR; CARDIORENAL SYNDROME; CASE REPORT; CONVULSION; DELIRIUM; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG WITHDRAWAL; EPILEPTIC STATE; FEMALE; HEART FAILURE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HEMOFILTRATION; HOSPITAL DISCHARGE; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY DISEASE; KIDNEY FUNCTION; LACTATE DEHYDROGENASE BLOOD LEVEL; LETTER; OLIGURIA; PLASMAPHERESIS; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RESTRICTIVE CARDIOMYOPATHY; SIDE EFFECT; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT WITHDRAWAL; CHEMICALLY INDUCED; POSTOPERATIVE COMPLICATIONS; THROMBOTIC MICROANGIOPATHIES;

ADULT; ANTIBODIES, MONOCLONAL, HUMANIZED; COMPLEMENT INACTIVATING AGENTS; FEMALE; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; POSTOPERATIVE COMPLICATIONS; TACROLIMUS; THROMBOTIC MICROANGIOPATHIES;

EID: 84930477381     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12551     Document Type: Letter

References (10)

1. George JN, Nester CM,. Syndromes of thrombotic microangiopathy. N Engl J Med 2014; 371: 654.
2. Noris M, Remuzzi G,. Atypical hemolytic-uremic syndrome. N Engl J Med 2009; 361: 1676.
3. Verbiest A, Pirenne J, Dierickx D,. De novo thrombotic microangiopathy after non-renal solid organ transplantation. Blood Rev 2014; 28: 269.
4. Mercadal L, Petitclerc T, Assogba U, Beaufils H, Deray G,. Hemolytic and uremic syndrome after heart transplantation. Am J Nephrology 2000; 20: 418.
5. Izquierdo MT, Almenar L, Martínez-Dolz L, Moro JA,. Hemolytic uremic syndrome due to sirolimus in a heart transplant recipient. Case report. Rev Esp Cardiol 2007; 60: 85.
6. Renner B, Klawitter J, Goldberg R, et al,. Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol 2013; 24: 1849.
7. Noris M, Mescia F, Remuzzi G,. STEC-HUS, atypical HUS and TTP are all diseases of complement activation. Nat Rev Nephrol 2012; 8: 622.
8. Jodele S, Fukuda T, Vinks A, et al,. Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biol Blood Marrow Transplant 2014; 20: 518.
9. Safa K, Logan MS, Batal I, Gabardi S, Rennke HG, Abdi R,. Eculizumab for drug-induced de novo post-transplantation thrombotic microangiopathy: a case report. Clin Nephrol 2015; 83: 125.
10. Kransdorf EP, Kittleson MM, Kobashigawa JA,. Atypical hemolytic-uremic syndrome immediately after heart transplantation. J Heart Lung Transplant 2014; 33: 664.