A neuropathological analysis of experimental autoimmune encephalomyelitis with predominant brain stem and cerebellar involvement and differences between active and passive induction

Acta Neuropathologica

Volumn 100, Issue 2, 2000, Pages 174-182

  Muller, Diane M ^a   Pender, Michael P ^a   Greer, Judith M ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Brain stem; Cerebellum; Experimental autoimmune encephalomyelitis Neuropathology; Myelin proteolipid protein

Indexed keywords

PROTEOLIPID PROTEIN;

ACTIVE IMMUNIZATION; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN STEM; CELL INFILTRATION; CEREBELLUM; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HEAD MOVEMENT; HISTOLOGY; INFLAMMATORY CELL; MONONUCLEAR CELL; MOTOR DYSFUNCTION; MOUSE; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; NEUTROPHIL; NONHUMAN; PARALYSIS; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; T LYMPHOCYTE; TRUNK;

EID: 0033920968     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004019900163     Document Type: Article

References (38)

1. Abromson-Leeman S, Bronson R, Dorf ME (1995) Experimental autoimmune peripheral neuritis induced in BALB/c mice by myelin basic protein-specific T cell clones. J Exp Med 182 : 587-592
2. Amor S, Groome N, Linington C, Morris MM, Dornmair K, Gardinier MV. Matthieu J-M, Baker D (1994) Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J Immunol 153 : 4349-4356
3. Butt AM, Ibrahim M, Ruge FM, Berry M (1995) Biochemical subtypes of oligodendrocyte in the anterior medullary velum of the rat as revealed by the monoclonal antibody Rip. Glia 14 : 185-197
4. Chalk JB, McCombe PA, Pender MP (1994) Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein. Brain 117 : 975-986
5. Chalk JB, McCombe PA, Smith R, Pender MP (1994) Clinical and histological findings in proteolipid protein-induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. Distribution of demyelination differs from that in EAE induced by other antigens. J Neurol Sci 123 : 154-161
6. Cross AH, O'Mara T, Raine CS (1993) Chronologic localisation of myelin-reactive cells in the lesions of relapsing EAE: implications for the study of multiple sclerosis. Neurology 43 : 1028-1033
7. Endoh M, Tabira T, Kunishita T, Sakai K, Yamamura T, Taketomi T (1986) DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice. J Immunol 137 : 3832-3835
8. Franklin K, Paxinos G (1997) The mouse brain in stereotaxic coordinates. Academic Press, San Diego
9. Greer JM, Kuchroo VK, Sobel RA, Lees MB (1992) Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J Immunol 149 : 783-788
10. Greer JM, Dyer CA, Pakaski M, Symonowicz C, Lees MB (1996) Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane. Neurochem Res 21 : 431-440
11. Greer JM, Sobel RA, Sette A, Southwood S, Lees MB, Kuchroo VK (1996) Immunogenic and encephalitogenic epilope clusters of myelin proteolipid protein. J Immunol 156 : 371-379
12. Greer JM, Csurhes PC, Cameron KD, McCombe PA, Good MF, Pender MP (1997) Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis. Brain 120 : 1447-1460
13. Hudson LD, Puckett C, Berndt J, Chan J, Gencic S (1989) Mutation of the proteolipid protein gene PLP in human X chromosome-linked myelin disorder. Proc Natl Acad Sci USA 86 : 8128-8131
14. Hurley JV (1983) Acute inflammation, 2nd edn. Churchill Livingstone, Edinburgh
15. Ichikawa M, Johns TG, Liu J, Bernard CC (1996) Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J Immunol 157 : 919-926
16. Kerlero de Rosbo N, Mendel I, Ben-Nun A (1995) Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. Eur J Immunol 25 : 985-993
17. Kuchroo VK, Sobel RA, Yamamura T, Greenfield E, Dorf ME, Lees MB (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid protein-specific T cell clones and synthetic peptides. Pathobiology 59 : 305-312
18. Lees MB, Paxman SA (1974) Myelin proteins from different regions of the central nervous system. J Neurochem 23 : 825-831
19. Levine S, Wenk EJ (1965) A hyperacute form of allergic encephalomyelitis. Am J Pathol 47 : 61-88
20. Linthicum DS, Munoz JJ, Blaskett A (1982) Acute experimental autoimmune encephalomyelitis in mice. Cell Immunol 73 : 299-310
21. Meade BD, Kind PD, Manclark CR (1984) Lymphocytosis-promoting factor of Bordetella pertussis alters mononuclear phagocyte circulation and response to inflammation. Infect Immun 46 : 733-739
22. Nguyen KB, Pender MP (1989) Assessment of myelination in glycol methacrylate sections: a new protocol for cresyl fast violet staining. Stain Technol 64 : 163-167
23. Pender MP (1986) Ascending impairment of nociception in rats with experimental allergic encephalomyelitis. J Neurol Sci 75 : 317-328
24. Pender MP (1988) The pathophysiology of acute experimental allergic encephalomyelitis induced by whole spinal cord in the Lewis rat. J Neurol Sci 84 : 209-222
25. Pender MP (1988) The pathophysiology of myelin basic protein-induced acute experimental allergic encephalomyelitis in the Lewis rat. J Neurol Sci 86 : 277-289
26. Pender MP (1995) Experimental autoimmune encephalomyelitis. In: Pender MP, McCombe PA (eds) Autoimmune neurological disease. Cambridge University Press, Cambridge, pp 26-88
27. Pender MP, Nguyen KB, Willenborg DO (1989) Demyelinatioji and early remyelination in experimental allergic encephalomyelitis passively transferred with myelin basic protein-sensitized lymphocytes in the Lewis rat. J Neuroimmunol 25 : 125-142
28. Pender MP, Tabi Z, Nguyen KB, McCombe PA (1995) The proximal peripheral nervous system is a major site of demyelinalion in experimental autoimmune encephalomyelitis induced in the Lewis rat by a myelin basic protein-specific T cell clone. Acta Neuropathol 89 : 527-531
29. Raine CS, Barnett LB, Brown A, Behar T, McFarlin DE (1980) Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice. Lab Invest 43 : 150-157
30. Shibasaki H, McDonald WI, Kuroiwa Y (1981) Racial modification of clinical picture of multiple sclerosis: comparison between British and Japanese patients. J Neurol Sci 49 : 253-271
31. Sobel RA, Tuohy VK, Lu Z, Laursen RA, Lees MB (1990) Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J Neuropathol Exp Neurol 49 : 468-479
32. Timsit S, Martinez S, Allinquant B, Peyron F, Puelles L, Zalc B (1995) Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression. J Neurosci 15 : 1012
33. Traugott U, Raine CS, McFarlin DE (1985) Acute experimental allergic encephalomyelitis in the mouse: immunopathology of the developing lesion. Cell Immunol 91 : 240-254
34. Tuohy VK, Sobel RA, Lees MB (1988) Myelin proteolipid protein-induced experimental allergic encephalomyelitis. J Immunol 140 : 1868-1873
35. Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP (1997) Diversity and plasticity of self recognition during the development of multiple sclerosis. J Clin Invest 99 : 1682-1690
36. Vass K, Heininger K, Schafer B, Linington C, Lassmann H (1992) Interferon-gamma potentiates antibody-mediated demyelination in vivo. Ann Neurol 32 : 198-206
37. Yan Y, Lagenaur C, Narayanan V (1993) Molecular cloning of M6: identification of a PLP/DM20 gene family. Neuron 11 : 423-431
38. Zamvil SS, Steinman L (1990) The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 8 : 579-621