The Relationship Between Metabolic Syndrome, Its Components, and Erectile Dysfunction: A Systematic Review and a Meta-Analysis of Observational Studies

Journal of Sexual Medicine

Volumn 12, Issue 6, 2015, Pages 1309-1318

  Besiroglu, Huseyin ^a   Otunctemur, Alper ^a   Ozbek, Emin ^b  

^a OKMEYDANI TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b ATATURK TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Erectile Dysfunction; Meta Analysis; Metabolic Syndrome; Observational Studies

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ARTICLE; BLOOD PRESSURE; CANADA; CARDIOVASCULAR RISK; CHINA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DYSLIPIDEMIA; ERECTILE DYSFUNCTION; FINLAND; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; HYPOGONADISM; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; METABOLIC SYNDROME X; OBESITY; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TAIWAN; TRIACYLGLYCEROL BLOOD LEVEL; TURKEY (REPUBLIC); UNITED STATES; WAIST CIRCUMFERENCE; WEIGHT REDUCTION; METABOLISM; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; RISK;

ERECTILE DYSFUNCTION; HUMANS; MALE; METABOLIC SYNDROME X; OBSERVATIONAL STUDY AS TOPIC; ODDS RATIO; PREVALENCE; PROSPECTIVE STUDIES; RISK; RISK FACTORS;

EID: 84930383314     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12885     Document Type: Review

References (44)

1. Expert Panel on Detection E, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) Expert Panel on Detection E, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
2. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome a summary of the evidence. Diabetes Care 2005;28:1769-1778.
3. Lewis JM, Osbourne AL, O'Leary MP. Erectile dysfunction-review. J Med Liban 2004;52:213-216.
4. Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB, McKinlay JB. Erectile dysfunction and coronary risk factors: Prospective results from the Massachusetts Aging Study. Prev Med 2000;30:328-338.
5. Solomon H, Man JW, Wierzbicki AS, Jackson G. Relation of erectile dysfunction to angiographic coronary artery disease. Am J Cardiol 2003;91:230-231.
6. Kloner RA, Mullin SH, Shook T, Matthews R, Mayeda G, Bustein S, Peled H, Pollick C, Choudhary R, Rosen R, Padma-Nathan H. Erectile dysfunction in the cardiac patient: How common and should we treat? J Urol 2003;170:46-50.
7. Jackson G. Erectile dysfunction might predict silent unobstructive coronary artery disease. BJU Int 2008;102:1496.
8. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991;14:173-194.
9. Thompson AM, Zhang Y, Tong W, Xu T, Chen J, Zhao L, Kelly TN, Chen CS, Bazzano LA, He J. Association of inflammation and endothelial dysfunction with metabolic syndrome, prediabetes and diabetes in adults from Inner Mongolia, China. BMC Endocr Disord 2011;11:16.
10. Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech 2009;2:231-237.
11. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;19:2008-2012.
12. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med 1997;127:820-826.
13. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560.
14. Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634.
15. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50:1088-1101.
16. Chao JK, Kuo WH, Chiang HS, Hwang TI, Chao IC, Chiang SK. Association of metabolic syndrome, atherosclerosis risk factors, sex hormones in ED in aboriginal Taiwanese. Int J Impot Res 2012;24:141-146.
17. Weinberg AE, Eisenberg M, Patel CJ, Chertow GM, Leppert JT. Diabetes severity, metabolic syndrome, and the risk of erectile dysfunction. J Sex Med 2013;10:3102-3109.
18. Pohjantähti-Maaroos H, Palomäki A, Hartikainen J. Erectile dysfunction, physical activity and metabolic syndrome: Differences in markers of atherosclerosis. BMC Cardiovasc Disord 2011;11:36.
19. Chen K, Mi H, Gao Y, Tan A, Lu Z, Wu C, Liao M, Zhang Y, Mo Z. Metabolic syndrome: A potential and independent risk factor for erectile dysfunction in the Chinese male population. Urology 2012;80:1287-1292.
20. Demir T, Demir O, Kefi A, Comlekci A, Yesil S, Esen A. Prevalence of erectile dysfunction in patients with metabolic syndrome. Int J Urol 2006;13:385-388.
21. Bal K, Oder M, Sahin AS, Karataş CT, Demir O, Can E, Gümüş BH, Ozer K, Sahin O, Esen AA. Prevalence of metabolic syndrome and its association with erectile dysfunction among urologic patients: Metabolic backgrounds of erectile dysfunction. Urology 2007;69:356-360.
22. Lee YC, Liu CC, Huang CN, Li WM, Wu WJ, Yeh HC, Wang CJ, Huang CH, Huang SP. The potential impact of metabolic syndrome on erectile dysfunction in aging Taiwanese males. J Sex Med 2010;7:3127-3134.
23. Grover SA, Lowensteyn I, Kaouache M, Marchand S, Coupal L, DeCarolis E, Zoccoli J, Defoy I. The prevalence of erectile dysfunction in the primary care setting: Importance of risk factors for diabetes and vascular disease. Arch Intern Med 2006;166:213-219.
24. O'Donnell AB, Araujo AB, Goldstein I, McKinlay JB. The validity of a single-question self-report of erectile dysfunction. Results from the Massachusetts Male Aging Study. J Gen Intern Med 2005;20:515-519.
25. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F. American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung and Blood Institute Scientific Statement. Circulation 2005;112:2735-2752.
26. Esposito K, Giugliano F, Ciotola M, Sio MD, D'Armiento M, Giugliano D. Obesity and sexual dysfunction, male and female. Int J Impot Res 2008;20:358-365.
27. Corona G, Mannucci E, Schulman C, Petrone L, Mansani R, Cilotti A, Balercia G, Chiarini V, Forti G, Maggi M. Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction. Eur Urol 2006;50:595-604.
28. Makhsida N, Shah J, Yan G, Fisch H, Shasigh R. Hypogonadism and metabolic syndrome: Implications for testosterone therapy. J Urol 2005;174:827-834.
29. Larsen SH, Wagner G, Heitmann BL. Sexual function and obesity. Int J Obes (Lond) 2007;31:1189-1198.
30. Vermeulen A, Kaufman JM, Deslypere JP, Thomas G. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab 1993;76:1140-1146.
31. Caprio M, Isidori AM, Carta AR, Moretti C, Dufau ML, Fabbri A. Expression of functional leptin receptors in rodent Leydig cells. Endocrinology 1999;140:4939-4947.
32. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
33. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB. Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study. J Urol 2000;163:460-463.
34. Behr-Roussel D, Gorny D, Mevel K, Compagnie S, Kern P, Sivan V, Bernabé J, Bedigian MP, Alexandre L, Giuliano F. Erectile dysfunction: An early marker for hypertension? A longitudinal study in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 2005;288:276-283.
35. Jaffe A, Chen Y, Kisch ES, Fischel B, Alon M, Stern N. Erectile dysfunction in hypertensive subjects. Assessment of potential determinants. Hypertension 1996;28:859-862.
36. Fogari R, Preti P, Zoppi A, Fogari E, Rinaldi A, Corradi L, Mugellini A. Serum testosterone levels and arterial blood pressure in the elderly. Hypertens Res 2005;28:625-630.
37. Ponholzer A, Temml C, Mock K, Marszalek M, Obermayr R, Madersbacher S. Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire. Eur Urol 2005;47:80-85.
38. Nicolosi A, Moreira ED Jr, Shirai M, Bin Mohd Tambi MI, Glasser DB. Epidemiology of erectile dysfunction in four countries: Cross-national study of the prevalence and correlates of erectile dysfunction. Urology 2003;61:201-206.
39. Roumeguère T, Wespes E, Carpentier Y, Hoffmann P, Schulman CC. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003;44:355-359.
40. Fung MM, Bettencourt R, Barrett-Connor E. Heart disease risk factors predict erectile dysfunction 25 years later: The Rancho Bernardo Study. J Am Coll Cardiol 2004;43:1405-1411.
41. Kim JH, Klyachkin ML, Svendsen E, Davies MG, Hagen PO, Carson CC 3rd. Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol 1994;151:198-205.
42. Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R. Prevalence and independent risk factors for erectile dysfunction in Spain: Results of the Epidemiologia de la Disfuncion Erectil Masculina Study. J Urol 2001;166:569-574.
43. Dunsmuir WD, Holmes SA. The aetiology and management of erectile, ejaculatory, and fertility problems in men with diabetes mellitus. Diabet Med 1996;13:700-708.
44. Corona G, Rastrelli G, Balercia G, Lotti F, Sforza A, Monami M, Forti G, Mannucci E, Maggi M. Hormonal association and sexual dysfunction in patients with impaired fasting glucose: A cross-sectional and longitudinal study. J Sex Med 2012;9:1669-1680.