RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis

EMBO Reports

Volumn 16, Issue 6, 2015, Pages 700-708

  Yonekawa, Tohru ^a   Gamez, Graciela ^a   Kim, Jihye ^a   Tan, Aik Choon ^a   Thorburn, Jackie ^a   Gump, Jacob ^a   Thorburn, Andrew ^a,b   Morgan, Michael J ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

autophagy; ERK; RIP1 (RIPK1); TFEB

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SERINE; SERINE THREONINE KINASE 1; SHORT HAIRPIN RNA; TFEB TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; RIPK1 PROTEIN, MOUSE; TFEB PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; BASAL AUTOPHAGY; CELL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENZYME PHOSPHORYLATION; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE IDENTIFICATION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL CULTURE; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; METABOLISM; MOUSE; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; APOPTOSIS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; LYSOSOMES; MICE; PHOSPHORYLATION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84930375285     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201439496     Document Type: Article

References (22)

1. Gump JM, Thorburn A, (2011) Autophagy and apoptosis: what is the connection? Trends Cell Biol 21: 387-392
2. Thorburn A, Thamm DH, Gustafson DL, (2014) Autophagy and cancer therapy. Mol Pharmacol 85: 830-838
3. Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DWH, Thorburn A, (2014) Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1. Nat Cell Biol 16: 47
4. Lin Y, (2014) RIP1-mediated signaling pathways in cell survival and death control. In Cell Death in Biology and Diseases: Necrotic Cell Death, Shen H, Vandenabeele P, (eds), Vol. 397, 23, pp 23-43. New York: Springer/Humana Press
5. Ting AT, PimentelMuinos FX, Seed B, (1996) RIP mediates tumor necrosis factor receptor 1 activation of NF-kappa B but not Fas/APO-1-initiated apoptosis. EMBO J 15: 6189-6196
6. Yuasa T, Ohno S, Kehrl JH, Kyriakis JM, (1998) Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38-Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem 273: 22681-22692
7. Morgan M, Liu Z, (2013) Programmed cell death with a necrotic-like phenotype. Biomol Concepts 4: 259-275
8. Wang L, Du FH, Wang XD, (2008) TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133: 693-703
9. Morgan MJ, Kim YS, Liu ZG, (2009) Membrane-bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex. J Immunol 183: 3278-3284
10. Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A, (2012) Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy 8: 200-212
11. Maycotte P, Gearheart CM, Barnard R, Aryal S, Mulcahy Levy JM, Fosmire SP, Hansen RJ, Morgan MJ, Porter CC, Gustafson DL, et al, (2014) STAT3-Mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious. Cancer Res 74: 2579-2590
12. Morgan MJ, Gamez G, Menke C, Hernandez A, Thorburn J, Gidan F, Staskiewicz L, Morgan S, Cummings C, Maycotte P, et al, (2014) Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy 10: 1814-1826
13. Hadji A, Ceppi P, Murmann AE, Brockway S, Pattanayak A, Bhinder B, Hau A, De Chant S, Parimi V, Kolesza P, et al, (2014) Death induced by CD95 or CD95 ligand elimination. Cell Rep 7: 208-222
14. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X, (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137: 1100-1111
15. Wang YQ, Wang L, Zhang MY, Wang T, Bao HJ, Liu WL, Dai DK, Zhang L, Chang P, Dong WW, et al, (2012) Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 37: 1849-1858
16. Chang P, Dong WW, Zhang MY, Wang ZF, Wang YQ, Wang T, Gao Y, Meng HH, Luo B, Luo CL, et al, (2014) Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice Intracerebral hemorrhage model. J Mol Neurosci 52: 242-249
17. Li HX, Kobayashi M, Blonska M, You Y, Lin X, (2006) Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappa B activation. J Biol Chem 281: 13636-13643
18. Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, et al, (2011) TFEB links autophagy to lysosomal biogenesis. Science 332: 1429-1433
19. Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, et al, (2012) A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 31: 1095-1108
20. Martina JA, Chen Y, Gucek M, Puertollano R, (2012) MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 8: 903-914
21. Thorburn J, Andrysik Z, Staskiewicz L, Gump J, Maycotte P, Oberst A, Green DR, Espinosa JM, Thorburn A, (2014) Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels. Cell Rep 7: 45-52
22. Kim J, Tan AC, (2012) BiNGS!SL-seq: a bioinformatics pipeline for the analysis and interpretation of deep sequencing genome-wide synthetic lethal screen. Methods Mol Biol 802: 389-398