Personal reflections on 25 years of immunodermatology

British Journal of Dermatology

Volumn 171, Issue 4, 2014, Pages 684-686

  Kupper, T S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CUTANEOUS LYMPHOCYTE ASSOCIATED ANTIGEN; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 23;

DERMATOLOGY; EDITORIAL; HOST RESISTANCE; HUMAN; IMMUNODERMATOLOGY; IMMUNOLOGY; LYMPHOCYTE HOMING; MEMORY T LYMPHOCYTE; PERSONAL EXPERIENCE; PRIORITY JOURNAL; PSORIASIS; SKIN; T LYMPHOCYTE SUBPOPULATION; TH17 CELL; SKIN DISEASE; TRENDS;

ALLERGY AND IMMUNOLOGY; DERMATOLOGY; HUMANS; SKIN; SKIN DISEASES;

EID: 84930369894     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13366     Document Type: Editorial

References (27)

1. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS,. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 1997; 389: 978-81.
2. Kupper TS,. Interleukin 1 and other human keratinocyte cytokines: molecular and functional characterization. Adv Dermatol 1988; 3: 293-307.
3. Kupper TS,. Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J Clin Invest 1990; 86: 1783-9.
4. Kupper TS, Fuhlbrigge RC,. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 2004; 4: 211-22.
5. Kupper TS,. T cells, immunosurveillance, and cutaneous immunity. J Dermatol Sci 2000; 24 (Suppl. 1): S41-5.
6. Robert C, Kupper TS,. Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med 1999; 341: 1817-28.
7. Groves RW, Giri J, Sims J, et al,. Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis. J Immunol 1995; 154: 4065-72.
8. Groves RW, Mizutani H, Kieffer JD, Kupper TS,. Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc Natl Acad Sci USA 1995; 92: 11874-8.
9. Groves RW, Rauschmayr T, Nakamura K, et al,. Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest 1996; 98: 336-44.
10. Nakamura K, Williams IR, Kupper TS,. Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin. J Invest Dermatol 1995; 105: 635-43.
11. Williams IR, Rawson EA, Manning L, et al,. IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells. J Immunol 1997; 159: 3044-56.
12. Kupper TS,. The utility of transgenic mouse models in the study of cutaneous immunology and inflammation. J Dermatol 1996; 23: 741-5.
13. Kupper TS,. The activated keratinocyte: a model for inducible cytokine production by non-bone marrow-derived cells in cutaneous inflammatory and immune responses. J Invest Dermatol 1990; 94: 146S-50S.
14. Berg EL, Yoshino T, Rott LS, et al,. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 1991; 174: 1461-6.
15. Picker LJ, Michie SA, Rott LS, Butcher EC,. A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am J Pathol 1990; 136: 1053-68.
16. Picker LJ, Terstappen LW, Rott LS, et al,. Differential expression of homing-associated adhesion molecules by T cell subsets in man. J Immunol 1990; 145: 3247-55.
17. Kupper TS,. Mechanisms of cutaneous inflammation. Interactions between epidermal cytokines, adhesion molecules, and leukocytes. Arch Dermatol 1989; 125: 1406-12.
18. Picker LJ, Butcher EC,. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol 1992; 10: 561-91.
19. Boyman O, Hefti HP, Conrad C, et al,. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α. J Exp Med 2004; 199: 731-6.
20. Clark RA, Chong B, Mirchandani N, et al,. The vast majority of CLA+ T cells are resident in normal skin. J Immunol 2006; 176: 4431-9.
21. Clark RA, Chong B, Mirchandani N, et al,. A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol 2006; 126: 1059-70.
22. Clark RA,. Skin-resident T cells: the ups and downs of on site immunity. J Invest Dermatol 2010; 130: 362-70.
23. Clark RA, Watanabe R, Teague JE, et al,. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med 2012; 4: 117ra7.
24. RM cells providing global skin immunity. Nature 2012; 483: 227-31.
25. Kupper TS,. Old and new: recent innovations in vaccine biology and skin T cells. J Invest Dermatol 2012; 132: 829-34.
26. RM) are abundant in human lung: diversity, function, and antigen specificity. PLoS One 2011; 6: e16245.
27. Campbell JJ, Clark RA, Watanabe R, Kupper TS,. Sézary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 2010; 116: 767-71.