IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: Evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells

Journal of Immunology

Volumn 159, Issue 6, 1997, Pages 3044-3056

  Williams, Ifor R ^a,b   Rawson, Elizabeth A ^a   Manning, Lisa ^a   Karaoli, Themis ^a   Rich, Benjamin E ^a   Kupper, Thomas S ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; GENETICS; HUMAN; IMMUNOLOGY; KERATINOCYTE; LYMPHOPROLIFERATIVE DISEASE; METABOLISM; MOUSE; SKIN DISEASE; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; HUMANS; INTERLEUKIN-7; KERATINOCYTES; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SKIN DISEASES; T-LYMPHOCYTES;

EID: 0031571783     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Namen, A. E., A. E. Schmierer, C. J. March, R. W. Overell, L. S. Park, D. L. Urdal, and D. Y. Mochizuki. 1988. B cell precursor growth-promoting activity: purification and characterization of a growth factor active on lymphocyte precursors. J. Exp. Med. 167:988.
2. Namen, A. E., S. Lupton, K. Hjerrild, J. Wignall, D. Y. Mochizuki, A. Schmierer, B. Mosley, C. J. March, D. Urdal, and S. Gillis. 1988. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571.
3. Conlon, P. J., P. J. Morrissey, R. P. Nordan, K. H. Grabstein, K. S. Prickett, S. G. Reed, R. Goodwin, D. Cosman, and A. E. Namen. 1989. Murine thymocytes proliferate in direct response to interleukin-7. Blood 74:1368.
4. Chantry, D., M. Turner, and M. Feldmann. 1989. Interleukin 7 (murine pre-B cell growth factor/lymphopoietin 1) stimulates thymocyte growth: regulation by transforming growth factor beta. Eur. J. Immunol. 19:783.
5. Morrissey, P. J., R. G. Goodwin, R. P. Nordan, D. Andersen, K. H. Grabstein, D. Cosman, J. Sims, S. Lupton, B. Acres, S. G. Reed, D. Mochizuki, J. Eisenman, P. J. Conlon, and A. E. Namen. 1989. Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells. J. Exp. Med. 169:707.
6. Chazen, G. D., G. M. B. Pereira, G. LeGros, S. Gillis, and E. M. Shevach. 1989. Interleukin 7 is a T-cell growth factor. Proc. Natl. Acad. Sci. USA 86:5923.
7. Welch, P. A., A. E. Namen, R. G. Goodwin, R. Armitage, and M. D. Cooper. 1989. Human IL-7: a novel T cell growth factor. J. Immunol. 143:3562.
8. Grabstein, K. H., A. E. Namen, K. Shanebeck, R. F. Voice, S. G. Reed, and M. B. Widmer. 1990. Regulation of T cell proliferation by IL-7. J. Immunol. 144:3015.
9. von Freeden-Jeffry, U., P. Vieira, L. A. Lucian, T. McNeil, S. E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519.
10. Peschon, J. J., P. J. Morrissey, K. H. Grabstein, F. J. Ramsdell, E. Maraskovsky, B. C. Gliniak, L. S. Park, S. F. Ziegler, D. E. Williams, C. B. Ware, J. D. Meyer, and B. L. Davison. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180:1955.
11. Maki, K., S. Sunaga, Y. Komagata, Y. Kodaira, A. Mabuchi, H. Karasuyama, K. Yokomuro, J. Miyazaki, and K. Ikuta. 1996. Interleukin 7 receptor-deficient mice lack γδ T cells. Proc. Natl. Acad. Sci. USA 93:7172.
12. -/- mice. J. Immunol. 157:2366.
13. + T cells, but not natural killer cells. J. Exp. Med. 184:289.
14. Gutierrez, J. C., and R. Palacios. 1991. Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivo. Proc. Natl. Acad. Sci. USA 88:642.
15. Heufler, C., G. Topar, A. Grasseger, U. Stanzl, F. Koch, N. Romani, A. E. Namen, and G. Schuler. 1993. Interleukin 7 is produced by murine and human keratinocytes. J. Exp. Med. 178:1109.
16. Watanabe, M., Y. Ueno, T. Yajima, Y. Iwao, M. Tsuchiya, H. Ishikawa, S. Aiso. T. Hibi, and H. Ishii. 1995. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 95:2945.
17. Matsue, H., P. R. Bergstresser, and A. Takashima. 1993. Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice. J. Immunol. 151:6012.
18. Muegge, K., M. P. Vila, and S. K. Durum. 1993. Interleukin-7: a cofactor for V(D)J rearrangement of me T cell receptor β gene. Science 261:93.
19. Watanabe, Y., T. Sudo, N. Minato, A. Ohnishi, and Y. Katsura. 1991. Interleukin 7 preferentially supports the growth of γδ T cell receptor-bearing T cells from fetal thymocytes in vitro. Int. Immunol. 3:1067.