Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: Data from the EXTEND study

American Journal of Hematology

Volumn 90, Issue 7, 2015, Pages 598-601

  Brynes, Russell K ^a   Orazi, Attilio ^b   Theodore, Dickens ^c   Burgess, Paul ^d   Bailey, Christine K ^c   Thein, Maung M ^a   Bakshi, Kalpana K ^c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c GLAXOSMITHKLINE   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ELTROMBOPAG; RETICULIN; BENZOIC ACID DERIVATIVE; HYDRAZINE DERIVATIVE; PYRAZOLE DERIVATIVE; THROMBOPOIETIN RECEPTOR;

ADULT; ARTICLE; BLOOD SMEAR; BONE MARROW; BONE MARROW BIOPSY; BRAIN INFARCTION; CLINICAL TRIAL; DRUG WITHDRAWAL; ERYTHROID PRECURSOR CELL; FEMALE; FOLLOW UP; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MEGAKARYOCYTE; MIDDLE AGED; MYELOFIBROSIS; MYELOID PROGENITOR CELL; PARESTHESIA; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOEMBOLISM; TRABECULAR BONE; TREATMENT DURATION; ANTAGONISTS AND INHIBITORS; BONE MARROW EXAMINATION; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PRIMARY MYELOFIBROSIS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RANDOMIZED CONTROLLED TRIAL;

ADULT; BENZOATES; BONE MARROW; BONE MARROW EXAMINATION; CHRONIC DISEASE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDRAZINES; MALE; MIDDLE AGED; PLATELET COUNT; PRIMARY MYELOFIBROSIS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; PYRAZOLES; RECEPTORS, THROMBOPOIETIN; RETICULIN;

EID: 84930331833     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.24011     Document Type: Article

References (15)

1. Erickson-Miller CL, DeLorme E, Tian SS, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol 2005;33:85-93.
2. Boiocchi L, Orazi A, Ghanima W, et al. Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities. Mod Pathol 2012;25:65-74.
3. Bussel JB, Kuter DJ, Pullarkat V, et al. Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood 2009;113:2161-2171.
4. Ghanima W, Junker P, Hasselbalch HC, et al. Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents. Br J Haematol 2011;155:248-255.
5. Kuter DJ, Bussel JB, Lyons RM, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: A double-blind randomised controlled trial. Lancet 2008; 371:395-403.
6. Kuter DJ, Mufti GJ, Bain BJ, et al. Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim. Blood 2009;114:3748-3756.
7. Saleh MN, Bussel JB, Cheng G, et al. Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood 2013;121:537-545.
8. Thiele J, Kvasnicka HM, Facchetti F, et al. European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica 2005;90:1128-1132.
9. Brynes R, Orazi A, Bakshi K, et al. Evaluation of the effects of long-term treatment with eltrombopag on bone marrow in patients with chronic immune thrombocytopenia (ITP) - data from the EXTEND study [abstract]. Blood 2013;122:326.
10. Ghanima W, Geyer JT, Lee CS, et al. Bone marrow fibrosis in 66 patients with immune thrombocytopenia treated with thrombopoietin-receptor agonists: A single-center, long-term follow-up. Haematologica 2014;99:937-944.
11. Ettrup MS, Jensen AO, Engebjerg MC, et al. Bone marrow reticulin and collagen content in patients with adult chronic immune thrombocytopenic purpura: A Danish nationwide study. Am J Hematol 2010;85:930-934.
12. Piatek CI, Vergara-Lluri ME, Pullarkat V, et al. Autoimmune myelofibrosis (AIMF) - clinical features, course and outcome [abstract]. Blood 2013;122:3714
13. Aharon A, Levy Y, Bar-Dayan Y, et al. Successful treatment of early secondary myelofibrosis in SLE with IVIG. Lupus 1997;6:408-411.
14. Frisch B, Bartl R, Burkhardt R. Bone marrow biopsy in clinical medicine: An overview. Haematologia (Budap) 1982;15:245-285.
15. Mufti G, Bagg A, Hasserjian R, et al. Bone marrow reticulin in patients with immune thrombocytopenic purpura [abstract]. Blood 2006;108:Abstract 3982.