-
1
-
-
54949131340
-
National trends in treatment of type 2 diabetes mellitus, 1994-2007
-
Alexander GC, Sehgal NL, Moloney RM and Stafford RS: National trends in treatment of type 2 diabetes mellitus, 1994-2007. Arch Intern Med 168: 2088-2094, 2008.
-
(2008)
Arch Intern Med
, vol.168
, pp. 2088-2094
-
-
Alexander, G.C.1
Sehgal, N.L.2
Moloney, R.M.3
Stafford, R.S.4
-
2
-
-
78651415908
-
Metformin and incident breast cancer among diabetic women: A population-based case-control study in Denmark
-
Bosco JL, Antonsen S, Sørensen HT, Pedersen L and Lash TL: Metformin and incident breast cancer among diabetic women: A population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev 20: 101-111, 2011.
-
(2011)
Cancer Epidemiol Biomarkers Prev
, vol.20
, pp. 101-111
-
-
Bosco, J.L.1
Antonsen, S.2
Sørensen, H.T.3
Pedersen, L.4
Lash, T.L.5
-
3
-
-
69249162223
-
Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth
-
Kisfalvi K, Eibl G, Sinnett-Smith J and Rozengurt E: Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. Cancer Res 69: 6539-6545, 2009.
-
(2009)
Cancer Res
, vol.69
, pp. 6539-6545
-
-
Kisfalvi, K.1
Eibl, G.2
Sinnett-Smith, J.3
Rozengurt, E.4
-
4
-
-
77956411030
-
Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
-
Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, et al: Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila) 3: 1077-1083, 2010.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1077-1083
-
-
Hosono, K.1
Endo, H.2
Takahashi, H.3
Sugiyama, M.4
Sakai, E.5
Uchiyama, T.6
Suzuki, K.7
Iida, H.8
Sakamoto, Y.9
Yoneda, K.10
-
5
-
-
79951592967
-
Metformin and the incidence of prostate cancer in patients with type 2 diabetes
-
Azoulay L, Dell'Aniello S, Gagnon B, Pollak M and Suissa S: Metformin and the incidence of prostate cancer in patients with type 2 diabetes. Cancer Epidemiol Biomarkers Prev 20: 337-344, 2011.
-
(2011)
Cancer Epidemiol Biomarkers Prev
, vol.20
, pp. 337-344
-
-
Azoulay, L.1
Dell'Aniello, S.2
Gagnon, B.3
Pollak, M.4
Suissa, S.5
-
6
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y and Bost F: The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27: 3576-3586, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 3576-3586
-
-
Ben Sahra, I.1
Laurent, K.2
Loubat, A.3
Giorgetti-Peraldi, S.4
Colosetti, P.5
Auberger, P.6
Tanti, J.F.7
Le Marchand-Brustel, Y.8
Bost, F.9
-
7
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch HA, Iliopoulos D, Tsichlis PN and Struhl K: Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69: 7507-7511, 2009.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
8
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B and Thompson CB: Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 67: 6745-6752, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
DeBerardinis, R.J.5
Zhao, F.6
Viollet, B.7
Thompson, C.B.8
-
9
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
Shackelford DB and Shaw RJ: The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression. Nat Rev Cancer 9: 563-575, 2009.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
10
-
-
84886419154
-
Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma
-
Zheng L, Yang W, Wu F, Wang C, Yu L, Tang L, Qiu B, Li Y, Guo L, Wu M, et al: Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clin Cancer Res 19: 5372-5380, 2013.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5372-5380
-
-
Zheng, L.1
Yang, W.2
Wu, F.3
Wang, C.4
Yu, L.5
Tang, L.6
Qiu, B.7
Li, Y.8
Guo, L.9
Wu, M.10
-
11
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn BB, Alquier T, Carling D and Hardie DG: AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25, 2005.
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
12
-
-
79959207505
-
Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth
-
Rocha GZ, Dias MM, Ropelle ER, Osório-Costa F, Rossato FA, Vercesi AE, Saad MJ and Carvalheira JB: Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res 17: 3993-4005, 2011.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3993-4005
-
-
Rocha, G.Z.1
Dias, M.M.2
Ropelle, E.R.3
Osório-Costa, F.4
Rossato, F.A.5
Vercesi, A.E.6
Saad, M.J.7
Carvalheira, J.B.8
-
13
-
-
36348950449
-
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
-
Dowling RJ, Zakikhani M, Fantus IG, Pollak M and Sonenberg N: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 67: 10804-10812, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 10804-10812
-
-
Dowling, R.J.1
Zakikhani, M.2
Fantus, I.G.3
Pollak, M.4
Sonenberg, N.5
-
14
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW and McMahon AP: Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 15: 3059-3087, 2001.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
15
-
-
51949085076
-
Hedgehog: Functions and mechanisms
-
Varjosalo M and Taipale J: Hedgehog: Functions and mechanisms. Genes Dev 22: 2454-2472, 2008.
-
(2008)
Genes Dev
, vol.22
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
16
-
-
0038625111
-
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
-
Zhu AJ, Zheng L, Suyama K and Scott MP: Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev 17: 1240-1252, 2003.
-
(2003)
Genes Dev
, vol.17
, pp. 1240-1252
-
-
Zhu, A.J.1
Zheng, L.2
Suyama, K.3
Scott, M.P.4
-
17
-
-
0033604515
-
Hedgehog signal transduction: From flies to vertebrates
-
Murone M, Rosenthal A and de Sauvage FJ: Hedgehog signal transduction: From flies to vertebrates. Exp Cell Res 253: 25-33, 1999.
-
(1999)
Exp Cell Res
, vol.253
, pp. 25-33
-
-
Murone, M.1
Rosenthal, A.2
De Sauvage, F.J.3
-
18
-
-
4344586961
-
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
-
Kubo M, Nakamura M, Tasaki A, Yamanaka N, Nakashima H, Nomura M, Kuroki S and Katano M: Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 64: 6071-6074, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 6071-6074
-
-
Kubo, M.1
Nakamura, M.2
Tasaki, A.3
Yamanaka, N.4
Nakashima, H.5
Nomura, M.6
Kuroki, S.7
Katano, M.8
-
19
-
-
84855888693
-
Hedgehog signaling pathway as a therapeutic target in various types of cancer
-
Onishi H and Katano M: Hedgehog signaling pathway as a therapeutic target in various types of cancer. Cancer Sci 102: 1756-1760, 2011.
-
(2011)
Cancer Sci
, vol.102
, pp. 1756-1760
-
-
Onishi, H.1
Katano, M.2
-
20
-
-
84891595114
-
High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma
-
Jeng KS, Sheen IS, Jeng WJ, Yu MC, Hsiau HI and Chang FY: High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma. Onco Targets Ther 7: 79-86, 2013.
-
(2013)
Onco Targets Ther
, vol.7
, pp. 79-86
-
-
Jeng, K.S.1
Sheen, I.S.2
Jeng, W.J.3
Yu, M.C.4
Hsiau, H.I.5
Chang, F.Y.6
-
21
-
-
84902290137
-
Metformin suppresses sonic hedgehog expression in pancreatic cancer cells
-
Nakamura M, Ogo A, Yamura M, Yamaguchi Y and Nakashima H: Metformin suppresses sonic hedgehog expression in pancreatic cancer cells. Anticancer Res 34: 1765-1769, 2014.
-
(2014)
Anticancer Res
, vol.34
, pp. 1765-1769
-
-
Nakamura, M.1
Ogo, A.2
Yamura, M.3
Yamaguchi, Y.4
Nakashima, H.5
-
22
-
-
72749103664
-
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
-
Visvader JE: Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 23: 2563-2577, 2009.
-
(2009)
Genes Dev
, vol.23
, pp. 2563-2577
-
-
Visvader, J.E.1
-
23
-
-
0037948854
-
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
-
Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ and Wicha MS: In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270, 2003.
-
(2003)
Genes Dev
, vol.17
, pp. 1253-1270
-
-
Dontu, G.1
Abdallah, W.M.2
Foley, J.M.3
Jackson, K.W.4
Clarke, M.F.5
Kawamura, M.J.6
Wicha, M.S.7
-
24
-
-
78650028237
-
The molecular pathology of breast cancer progression
-
Bombonati A and Sgroi DC: The molecular pathology of breast cancer progression. J Pathol 223: 307-317, 2011.
-
(2011)
J Pathol
, vol.223
, pp. 307-317
-
-
Bombonati, A.1
Sgroi, D.C.2
-
25
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
28
-
-
45549103691
-
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy
-
Kakarala M and Wicha MS: Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol 26: 2813-2820, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2813-2820
-
-
Kakarala, M.1
Wicha, M.S.2
-
29
-
-
68749099671
-
Identification of selective inhibitors of cancer stem cells by high-throughput screening
-
Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA and Lander ES: Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138: 645-659, 2009.
-
(2009)
Cell
, vol.138
, pp. 645-659
-
-
Gupta, P.B.1
Onder, T.T.2
Jiang, G.3
Tao, K.4
Kuperwasser, C.5
Weinberg, R.A.6
Lander, E.S.7
-
30
-
-
79955834631
-
Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo
-
Rattan R, Graham RP, Maguire JL, Giri S and Shridhar V: Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 13: 483-491, 2011.
-
(2011)
Neoplasia
, vol.13
, pp. 483-491
-
-
Rattan, R.1
Graham, R.P.2
Maguire, J.L.3
Giri, S.4
Shridhar, V.5
-
31
-
-
78751692291
-
Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner
-
Rattan R, Giri S, Hartmann LC and Shridhar V: Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. J Cell Mol Med 15: 166-178, 2011.
-
(2011)
J Cell Mol Med
, vol.15
, pp. 166-178
-
-
Rattan, R.1
Giri, S.2
Hartmann, L.C.3
Shridhar, V.4
-
32
-
-
77953539812
-
Long-term metformin use is associated with decreased risk of breast cancer
-
Bodmer M, Meier C, Krähenbühl S, Jick SS and Meier CR: Long-term metformin use is associated with decreased risk of breast cancer. Diabetes Care 33: 1304-1308, 2010.
-
(2010)
Diabetes Care
, vol.33
, pp. 1304-1308
-
-
Bodmer, M.1
Meier, C.2
Krähenbühl, S.3
Jick, S.S.4
Meier, C.R.5
-
33
-
-
33751284806
-
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
-
Zakikhani M, Dowling R, Fantus IG, Sonenberg N and Pollak M: Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 66: 10269-10273, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 10269-10273
-
-
Zakikhani, M.1
Dowling, R.2
Fantus, I.G.3
Sonenberg, N.4
Pollak, M.5
-
34
-
-
84904686912
-
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
-
Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC and Struhl K: Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci USA 111: 10574-10579, 2014.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 10574-10579
-
-
Janzer, A.1
German, N.J.2
Gonzalez-Herrera, K.N.3
Asara, J.M.4
Haigis, M.C.5
Struhl, K.6
-
35
-
-
84867116494
-
Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway
-
Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL and Majumder S: Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. Cancer Res 72: 5048-5059, 2012.
-
(2012)
Cancer Res
, vol.72
, pp. 5048-5059
-
-
Ramaswamy, B.1
Lu, Y.2
Teng, K.Y.3
Nuovo, G.4
Li, X.5
Shapiro, C.L.6
Majumder, S.7
|