Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone

Psychopharmacology

Volumn 231, Issue 17, 2014, Pages 3503-3515

  Ayoola, Christine ^a   Hwang, Sung Mi ^a,c   Hong, Sung Jun ^a,c   Rose, Kirstin E ^a   Boyd, Christopher ^a   Bozic, Neda ^a   Park, Ji Yong ^d   Osuru, Hari Prasad ^a   DiGruccio, Michael R ^a   Covey, Douglas F ^b   Jevtovic Todorovic, Vesna ^a   Todorovic, Slobodan M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c Hallym University   (South Korea)

^d Korea University College of Medicine   (South Korea)

Author keywords

Ca2+; Dorsal root; Hyperalgesia; Low voltage activated; Pain

Indexed keywords

3BETA HYDROXY 5BETA PREGNAN 20 ONE; CALCIUM CHANNEL T TYPE; CALCIUM CHANNEL T TYPE CAV3.2; POTASSIUM; SODIUM; UNCLASSIFIED DRUG; ANALGESIC AGENT; CACNA1H PROTEIN, MOUSE; CACNA1H PROTEIN, RAT; CALCIUM CHANNEL BLOCKING AGENT; ELTANOLONE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HYPERPOLARIZATION; IC50; IN VITRO STUDY; IN VIVO STUDY; INTRAPLANTAR DRUG ADMINISTRATION; MEMBRANE POTENTIAL; NOCICEPTION; NONHUMAN; PAIN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SENSORY NERVE CELL; SPINAL GANGLION; STIMULUS RESPONSE; ANIMAL; ANIMAL BEHAVIOR; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MALE; MOUSE; PAIN MEASUREMENT; PAIN RECEPTOR; PATCH CLAMP TECHNIQUE; PERIPHERAL NERVE;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; FEMALE; MALE; MICE; MICE, KNOCKOUT; NOCICEPTORS; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; PERIPHERAL NERVES; PREGNANOLONE; RATS; SENSORY RECEPTOR CELLS;

EID: 84930278582     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3588-0     Document Type: Article

References (23)

1. Barbara G, Alloui A, Nargeot J, Lory P, Eschalier A, Bourinet E, Chemin J (2009) T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. J Neurosci 29:13106-13114
2. Bicikova M, Hill M, Ripova D, Mohr P, Hampl R (2013) Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia. J Steroid Biochem Mol Biol 133:77-83
3. Campbell JN, Meyer RA (2006) Mechanisms of neuropathic pain. Neuron 52(1):77-92
4. 2+ channels. Science 302:1416-1418
5. Choe WJ, Messinger RB, Leach E, Eckle V-S, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM (2011) TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol 80(5):900-910
6. V3.2 T-type channels. Genes Brain Behav 6(5):425-431
7. V3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J Neurosci 32(27):9374-9382
8. Jagodic MM, Pathirathna S, Nelson MT, Mancuso S, Joksovic PM, Rosenberg ER, Bayliss DA, Jevtovic-Todorovic V, Todorovic SM (2007) Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci 27(12):3305-3316
9. Jevtovic-Todorovic V, Covey DF, Todorovic SM (2009) Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychopharmacology 34(Suppl 1):S178-S185
10. Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM (2009) Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci 29(30):9500-9509
11. Liu S, Sjövall J, Griffiths WJ (2003) Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatography-electrospray mass spectrometry. Anal Chem 75(21):5835-5846
12. 2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J Neurosci 25(38):8766-8775
13. A channels are responsible for the potent peripheral analgesic effects of 5α-reduced neuroactive steroids. Pain 114:429-443
14. Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V (2005b) 5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain 117:326-339
15. Patte-Mensah C, Meyer L, Schaeffer V, Mensah-Nyagan AG (2010) Selective regulation of 3 alpha-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: a possible mechanism to cope with peripheral nerve injury-induced chronic pain. Pain 150(3):522-534
16. A receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model. J Physiol 500(Pt 2):475-485
17. V3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience 250:263-274
18. Todorovic SM, Jevtovic-Todorovic V (2013) Neuropathic pain: role of presynaptic T-type channels in nociceptive signaling. Pflugers Archiv - European Journal of Physiology 465(7):921-927
19. 2+ current in adult rat sensory neurons by a steroid that lacks GABA-modulatory activity. Mol Pharmacol 54:918-927
20. 2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol 66(5):1223-1235
21. A receptor antagonists. J Neurosci 22(9):3366-3375
22. Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ (2004) The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. Br J Anaesth 92(5):704-711
23. Zorumski CF, Paul SM, Izumi Y, Covey DF, Mennerick S (2013) Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev 37(1):109-122