Investigation of Central Nervous System Dysfunction in Chronic Pelvic Pain Using Magnetic Resonance Spectroscopy and Noninvasive Brain Stimulation

Pain Practice

Volumn 15, Issue 5, 2015, Pages 423-432

  Simis, Marcel ^a,b,c   Reidler, Jay S ^a   Duarte Macea, Debora ^a   Moreno Duarte, Ingrid ^a   Wang, Xiaoen ^a   Lenkinski, Robert ^a   Petrozza, John C ^a   Fregni, Felipe ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Santa Casa de Sao Paulo Medical School   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Brain stimulation; Chronic pelvic pain; Magnetic resonance spectroscopy; TDCS; Transcranial direct current stimulation

Indexed keywords

ADULT; ANTERIOR CINGULATE; ARTICLE; BRAIN DEPTH STIMULATION; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ARTICLE; CONNECTOME; DISEASE ASSOCIATION; FEMALE; HUMAN; MALE; METABOLITE; NEUROMODULATION; NON INVASIVE PROCEDURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL CORTEX; PAIN THRESHOLD; PELVIS PAIN SYNDROME; PRIMARY MOTOR CORTEX; THALAMUS; TRANSCRANIAL DIRECT CURRENT STIMULATION; ANALGESIA; CHRONIC PAIN; CONTROLLED STUDY; ELECTROTHERAPY; METABOLISM; MIDDLE AGED; MOTOR CORTEX; PAIN MEASUREMENT; PELVIC PAIN; PROCEDURES; RANDOMIZED CONTROLLED TRIAL;

ADULT; CHRONIC PAIN; ELECTRIC STIMULATION THERAPY; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MOTOR CORTEX; PAIN MANAGEMENT; PAIN MEASUREMENT; PELVIC PAIN; TRANSCRANIAL DIRECT CURRENT STIMULATION;

EID: 84930243707     PISSN: 15307085     EISSN: 15332500     Source Type: Journal    
DOI: 10.1111/papr.12202     Document Type: Article

References (39)

1. Savidge CJ, Slade P. Psychological aspects of chronic pelvic pain. J Psychosom Res. 1997;42:433-444.
2. Grace V, Zondervan K. Chronic pelvic pain in women in New Zealand: comparative well-being, comorbidity, and impact on work and other activities. Health Care Women Int. 2006;27:585-599.
3. Woolf CJ. Central sensitization: uncovering the relation between pain and plasticity. Anesthesiology. 2007;106:864-867.
4. Fenton BW. Limbic associated pelvic pain: a hypothesis to explain the diagnostic relationships and features of patients with chronic pelvic pain. Med Hypotheses. 2007;69:282-286.
5. Fenton BW, Palmieri PA, Boggio P, Fanning J, Fregni F. A preliminary study of transcranial direct current stimulation for the treatment of refractory chronic pelvic pain. Brain Stimul. 2009;2:103-107.
6. Fregni F, Freedman S, Pascual-Leone A. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. Lancet Neurol. 2007;6:188-191.
7. Fregni F, Gimenes R, Valle AC, et al. A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain. 2006;122:197-209.
8. Fregni F, Boggio PS, Lima MC, et al. A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum. 2006;54:3988-3998.
9. Cecilio SB, Zaghi S, Cecilio LB, Correa CF, Fregni F. Exploring a novel therapeutic approach with noninvasive cortical stimulation for vulvodynia. Am J Obstet Gynecol. 2008;199:e6-e7.
10. Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J physiol. 2000;527(Pt 3):633-639.
11. Gandiga PC, Hummel FC, Cohen LG. Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clin Neurophysiol. 2006;117:845-850.
12. Reidler JS, Mendonca ME, Santana MB, et al. Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects. J Pain. 2012;13:450-458.
13. Feraco P, Bacci A, Pedrabissi F, et al. Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study. AJNR Am J Neuroradiol. 2011;32:1585-1590.
14. Pattany PM, Yezierski RP, Widerstrom-Noga EG, et al. Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury. AJNR Am J Neuroradiol. 2002;23:901-905.
15. Fukui S, Matsuno M, Inubushi T, Nosaka S. N-Acetylaspartate concentrations in the thalami of neuropathic pain patients and healthy comparison subjects measured with (1)H-MRS. Magn Reson Imaging. 2006;24:75-79.
16. Peyron R, Garcia-Larrea L, Gregoire MC, et al. Parietal and cingulate processes in central pain. A combined positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) study of an unusual case. Pain. 2000;84:77-87.
17. Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F. A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int J Neuropsychopharmacol. 2011;14:1133-1145.
18. Grachev ID, Fredrickson BE, Apkarian AV. Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study. Pain. 2000;89:7-18.
19. Fayed N, Garcia-Campayo J, Magallon R, et al. Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate. Arthritis Res Ther. 2010;12:R134.
20. Harris RE, Sundgren PC, Craig AD, et al. Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis Rheum. 2009;60:3146-3152.
21. Valdes M, Collado A, Bargallo N, et al. Increased glutamate/glutamine compounds in the brains of patients with fibromyalgia: a magnetic resonance spectroscopy study. Arthritis Rheum. 2010;62:1829-1836.
22. Fayed N, Andres E, Rojas G, et al. Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. Acta Psychiatr Scand. 2012;126:115-125.
23. Mullins PG, Rowland LM, Jung RE, Sibbitt WL, Jr. A novel technique to study the brain's response to pain: proton magnetic resonance spectroscopy. Neuroimage. 2005;26:642-646.
24. Gussew A, Rzanny R, Erdtel M, et al. Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation. Neuroimage. 2010;49:1895-1902.
25. Staud R, Weyl EE, Price DD, Robinson ME. Mechanical and heat hyperalgesia highly predict clinical pain intensity in patients with chronic musculoskeletal pain syndromes. J Pain. 2012;13:725-735.
26. Gussew A, Rzanny R, Gullmar D, Scholle HC, Reichenbach JR, et al. 1H-MR spectroscopic detection of metabolic changes in pain processing brain regions in the presence of non-specific chronic low back pain. Neuroimage. 2011;54:1315-1323.
27. Govindaraju V, Young K, Maudsley AA. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 2000;13:129-153.
28. Sharma NK, McCarson K, Van Dillen L, Lentz A, Khan T, Cirstea CM. Primary somatosensory cortex in chronic low back pain - a H-MRS study. J Pain Res. 2011;4:143-150.
29. Sorensen L, Siddall PJ, Trenell MI, Yue DK. Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy. Diabetes Care. 2008;31:980-981.
30. Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci. 1993;15:289-298.
31. Lima MC, Fregni F. Motor cortex stimulation for chronic pain: systematic review and meta-analysis of the literature. Neurology. 2008;70:2329-2337.
32. Lefaucheur JP, Drouot X, Nguyen JP. Interventional neurophysiology for pain control: duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex. Neurophysiol Clin. 2001;31:247-252.
33. Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T, Koyama S. Chronic motor cortex stimulation for the treatment of central pain. Acta Neurochir Suppl (Wien). 1991;52:137-139.
34. Knotkova H, Nitsche MA, Cruciani RA. Putative physiological mechanisms underlying tDCS analgesic effects. Front Hum Neurosci. 2013;7:628.
35. Peyron R, Garcia-Larrea L, Deiber MP, Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study. Pain. 1995;62:275-286.
36. Garcia-Larrea L, Peyron R, Mertens P, et al. Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study. Pain. 1999;83:259-273.
37. Strafella AP, Vanderwerf Y, Sadikot AF. Transcranial magnetic stimulation of the human motor cortex influences the neuronal activity of subthalamic nucleus. Eur J Neurosci. 2004;20:2245-2249.
38. Lang N, Siebner HR, Ward NS, Peyron R, Mertens P, et al. How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? Eur J Neurosci. 2005;22:495-504.
39. Garcia-Larrea L, Peyron R, Mertens P, et al. Positron emission tomography during motor cortex stimulation for pain control. Stereotact Funct Neurosurg. 1997;68:141-148.