Delivery of aerosolized liposomal amikacin as a novel approach for the treatment of nontuberculous mycobacteria in an experimental model of pulmonary infection

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Rose, Sasha J ^a   Neville, Mary E ^b   Gupta, Renu ^b   Bermudez, Luiz E ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b Insmed Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; LIPOSOME; AEROSOL; TUBERCULOSTATIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; ATYPICAL MYCOBACTERIOSIS; ATYPICAL MYCOBACTERIUM; BACTERIAL STRAIN; BACTERIAL SURVIVAL; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LUNG INFECTION; MACROPHAGE; MOUSE; MYCOBACTERIUM ABSCESSUS; NONHUMAN; AEROSOL; ANIMAL; BACTERIAL COUNT; C57BL MOUSE; CELL LINE; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTRACELLULAR SPACE; ISOLATION AND PURIFICATION; LUNG; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; PATHOLOGY; RESPIRATORY TRACT INFECTIONS;

ADMINISTRATION, INHALATION; AEROSOLS; AMIKACIN; ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; INTRACELLULAR SPACE; LIPOSOMES; LUNG; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; NONTUBERCULOUS MYCOBACTERIA; RESPIRATORY TRACT INFECTIONS;

EID: 84930223841     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108703     Document Type: Article

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