Rate and equilibrium constants for the addition of N-heterocyclic carbenes into benzaldehydes: A remarkable 2-substituent effect

Angewandte Chemie - International Edition

Volumn 54, Issue 23, 2015, Pages 6887-6892

  Collett, Christopher J ^a   Massey, Richard S ^b   Taylor, James E ^a   Maguire, Oliver R ^b   O'Donoghue, AnnMarie C ^b   Smith, Andrew D ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

2 substituent effect; kinetics; mechanistic studies; N heterocyclic carbenes; organocatalysis

Indexed keywords

ALDEHYDES; ENZYME KINETICS; KINETICS; ORGANIC COMPOUNDS; RATE CONSTANTS; REACTION INTERMEDIATES;

2-SUBSTITUENT EFFECT; CHEMO-SELECTIVITY; MECHANISTIC STUDIES; N-HETEROCYCLIC CARBENES; ORGANOCATALYSIS; REVERSE REACTIONS; SUBSTITUTED BENZALDEHYDES; THERMODYNAMIC EFFECT;

EQUILIBRIUM CONSTANTS;

EID: 84930221830     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201501840     Document Type: Article

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