Early hemostatic responses to trauma identified with hierarchical clustering analysis

Journal of Thrombosis and Haemostasis

Volumn 13, Issue 6, 2015, Pages 978-988

  White, N J ^a   Contaifer, D ^b   Martin, E J ^b   Newton, J C ^b   Mohammed, B M ^b,c   Bostic, J L ^b   Brophy, G M ^d   Spiess, B D ^d   Pusateri, A E ^e   Ward, K R ^f   Brophy, D F ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c CAIRO UNIVERSITY   (Egypt)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

^f UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Coagulation; Fibrinogen; Hemostasis; Platelets; Thrombin; Trauma

Indexed keywords

D DIMER; FIBRINOGEN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; BIOLOGICAL MARKER; THROMBIN;

ADULT; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; CLUSTER ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FEMALE; FIBRINOGEN BLOOD LEVEL; FIBRINOLYSIS; HEMORRHAGIC SHOCK; HEMOSTASIS; HIERARCHICAL CLUSTERING ANALYSIS; HUMAN; INTERNATIONAL NORMALIZED RATIO; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIPLE TRAUMA; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PHENOTYPE; PRIORITY JOURNAL; THROMBIN TIME; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; UNITED STATES; VITAL SIGN; BAYES THEOREM; BLOOD; BLOOD CLOTTING; BLOOD CLOTTING PARAMETERS; DISCRIMINANT ANALYSIS; EMERGENCY HEALTH SERVICE; INJURY; INJURY SCALE; METABOLISM; MIDDLE AGED; PREDICTIVE VALUE; TIME FACTOR; URBAN HEALTH; YOUNG ADULT;

ADULT; BAYES THEOREM; BIOMARKERS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; CLUSTER ANALYSIS; CROSS-SECTIONAL STUDIES; DISCRIMINANT ANALYSIS; FEMALE; FIBRINOGEN; FIBRINOLYSIS; HEMOSTASIS; HUMANS; INFLAMMATION MEDIATORS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PHENOTYPE; PLATELET ACTIVATION; PLATELET FUNCTION TESTS; PREDICTIVE VALUE OF TESTS; THROMBIN; TIME FACTORS; TRAUMA CENTERS; UNITED STATES; URBAN HEALTH; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84930181120     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12919     Document Type: Article

References (26)

1. Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, DePasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM. Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock 2014; 41: 3-12.
2. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma Acute Care Surg 2003; 54: 1127-30.
3. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet J. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 2007; 245: 812-18.
4. Cardenas JC, Matijevic N, Baer LA, Holcomb JB, Cotton BA, Wade CE. Elevated tissue plasminogen activator and reduced plasminogen activator inhibitor promote hyperfibrinolysis in trauma patients. Shock 2014; 41: 514-21.
5. Oshiro A, Yanagida Y, Gando S, Henzan N, Takahashi I. Makise H Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation. Crit Care 2014; 3: R61-70.
6. Kutcher ME, Redick BJ, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Nelson MF, Cohen MJ. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg 2012; 73: 13-19.
7. Roumen RM, Hendriks T, van der Ven-Jongekrijg J, Nieuwenhuijzen GAP, Sauerwein RW, van der Meer JW, Goris RJA. Cytokine patterns in patients after major surgery, hemorrhagic shock, and severe blunt trauma. Ann Surg 1993; 6: 769-76.
8. Bogner V, Keil L, Kanz KG, Kirchhoff C, Leidel BA, Mutschler W, Biberthaler P. Very early posttraumatic serum alterations are significantly associated to initial massive RBC substitution, injury severity, multiple organ failure and adverse clinical outcome in multiple injured patients. Eur J Med Res 2009; 14: 284-91.
9. Hu CH, Harris JE, Davie EW, Chung DW. Characterization of the 5'-flanking region of the gene for the alpha chain of human fibrinogen. J Biol Chem 1995; 270: 28342-9.
10. Johansson PI, Sørensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR. High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J Thromb Haemost 2012; 10: 207-16.
11. Haywood-Watson RJ, Holcomb JB, Gonzalez EA, Peng Z, Pati S, Park PW, Wang W, Zaske AM, Menge T, Kozar RA. Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation. PLoS One 2011; 6: e23530.
12. Berkhin P. A Survey of Clustering Data Mining Techniques. Berlin, Heidelberg: Grouping Multidimensional Data - Springer, 2006: 25-71.
13. Draisma HH, Reijmers TH, Meulman JJ, van der Greef J, Hankemeier T, Boomsma DI. Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families. Eur J Hum Genet 2013; 21: 95-101.
14. Cohen MJ1, Grossman AD, Morabito D, Knudson MM, Butte AJ, Manley GT. Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care 2010; 14: R10-21.
15. Schöchl H, Frietsch T, Pavelka M, Jámbor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thromboelastometry. J Trauma Acute Care Surg 2007; 67: 125-31.
16. Mammen EF, Comp PC, Gosselin R, Greenberg C, Hoots WK, Kessler CM, Larkin EC, Liles D, Nugent DJ. PFA-100 system: a new method for assessment of platelet dysfunction. Semin Thromb Hemost 1998; 24: 195-202.
17. Di Paola J, Federici AB, Mannucci PM, Canciani MT, Kritzik M, Kunicki TJ, Nugent D. Low platelet alpha2beta1 levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system. Blood 1999; 93: 3578-82.
18. Milligan GW. Clustering validation: results and implications for applied analyses. Clustering and Classification 1996; 341-75.
19. Fraley C, Raftery AE. Model-based clustering, discriminant analysis, and density estimation. J Am Stat Assoc 2002; 97: 611-31.
20. Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Khan S, Adams PR, McCarthy JJ, Cotton BA. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg 2012; 56: 476-86.
21. Branco BC, Inaba K, Ives C, Okoye O, Shulman I, David JS, Schöchl H, Rhee P, Demetriades D. Thromboelastogram evaluation of the impact of hypercoagulability in trauma patients. Shock 2014; 41: 200-7.
22. Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R, Pasi KJ, MacCallum P, Stanworth S, Brohi K. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med 2011; 39: 2652-8.
23. Hagemo JS, Stanworth S, Juffermans NP, Brohi K, Cohen M, Johansson PI, Røislien J, Eken T, Næss PA, Gaarder C. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study. Crit Care 2014; 18: R52-60.
24. Hoffman M, Monroe DM 3rd. A cell-based model of hemostasis. Thromb Haemost 2001; 85: 958-65.
25. Jacoby RC, Owings JT, Holmes J, Battistella FD, Gosselin RC, Paglieroni TG. Platelet activation and function after trauma. J Trauma 2001; 51: 639-47.
26. Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg 2014; 77: 811-17.