The neonatal Fc receptor does not modulate hepatitis C virus neutralization

Journal of General Virology

Volumn 96, Issue 5, 2015, Pages 1062-1066

  Morel, Anthony ^a   Passot, Christophe ^a   Arnoult, Christophe ^a   Dumans, Amèlie ^a   Beaumont, Elodie ^a   Gouilleux Gruart, Valèrie ^a   Roingeard, Philippe ^a   Blanchard, Emmanuelle ^a  

^a UNIVERSITÉ DE TOURS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; FC RECEPTOR, NEONATAL; HLA ANTIGEN CLASS 1; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; FLOW CYTOMETRY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS SUBTYPE 1B; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMORAL IMMUNITY; INFLUENZA VIRUS A; KNOCKOUT MOUSE; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA REPLICATION; VIRAL CLEARANCE; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; VIRUS PARTICLE; VIRUS REPLICATION; WESTERN BLOTTING; HEPACIVIRUS; IMMUNOLOGY; METABOLISM; NEWBORN; SERODIAGNOSIS;

HEPATITIS C VIRUS; INFLUENZA A VIRUS;

ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; HEPACIVIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INFANT, NEWBORN; NEUTRALIZATION TESTS; RECEPTORS, FC;

EID: 84930159950     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.000060     Document Type: Article

References (16)

1. Akilesh, S., Christianson, G. J., Roopenian, D. C. & Shaw, A. S. (2007). Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol 179, 4580–4588.
2. Bai, Y., Ye, L., Tesar, D. B., Song, H., Zhao, D., Björkman, P. J., Roopenian, D. C. & Zhu, X. (2011). Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci U S A 108, 18406–18411.
3. Bartosch, B., Dubuisson, J. & Cosset, F.-L. (2003). Infectious hepatitis C virus pseudo-particles containing functional E1–E2 envelope protein complexes. J Exp Med 197, 633–642.
4. Dorner, M., Horwitz, J. A., Robbins, J. B., Barry, W. T., Feng, Q., Mu, K., Jones, C. T., Schoggins, J. W., Catanese, M. T. & other authors (2011). A genetically humanized mouse model for hepatitis C virus infection. Nature 474, 208–211.
5. Giang, E., Dorner, M., Prentoe, J. C., Dreux, M., Evans, M. J., Bukh, J., Rice, C. M., Ploss, A., Burton, D. R. & Law, M. (2012). Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc Natl Acad Sci U S A 109, 6205–6210.
6. Lavillette, D., Morice, Y., Germanidis, G., Donot, P., Soulier, A., Pagkalos, E., Sakellariou, G., Intrator, L., Bartosch, B. & other authors (2005). Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection. J Virol 79, 6023–6034.
7. Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, A. W., Stamataki, Z., Gastaminza, P., Chisari, F. V., Jones, I. M. & other authors (2008). Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med 14, 25–27.
8. Lohmann, V. & Bartenschlager, R. (2014). On the history of hepatitis C virus cell culture systems. J Med Chem 57, 1627–1642.
9. Pestka, J. M., Zeisel, M. B., Bläser, E., Schürmann, P., Bartosch, B., Cosset, F.-L., Patel, A. H., Meisel, H., Baumert, J. & other authors (2007). Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci U S A 104, 6025–6030.
10. Raghavan, M., Bonagura, V. R., Morrison, S. L. & Bjorkman, P. J. (1995). Analysis of the pH dependence of the neonatal Fc receptor/ immunoglobulin G interaction using antibody and receptor variants. Biochemistry 34, 14649–14657.
11. Roopenian, D. C. & Akilesh, S. (2007). FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 7, 715–725.
12. Sabo, M. C., Luca, V. C., Prentoe, J., Hopcraft, S. E., Blight, K. J., Yi, M., Lemon, S. M., Ball, J. K., Bukh, J. & other authors (2011). Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step. J Virol 85, 7005–7019.
13. Sautto, G. A., Diotti, R. A. & Clementi, M. (2012). New therapeutic options for HCV infection in the monoclonal antibody era. New Microbiol 35, 387–397.
14. Schilling, R., Ijaz, S., Davidoff, M., Lee, J. Y., Locarnini, S., Williams, R. & Naoumov, N. V. (2003). Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions. J Virol 77, 8882–8892.
15. Tesar, D. B., Tiangco, N. E. & Bjorkman, P. J. (2006). Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor. Traffic 7, 1127–1142.
16. Zhu, X., Meng, G., Dickinson, B. L., Li, X., Mizoguchi, E., Miao, L., Wang, Y., Robert, C., Wu, B. & other authors (2001). MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol 166, 3266–3276.