Development and characterization of a novel, antimicrobial, sterile hydrogel dressing for burn wounds: Single-step production with gamma irradiation creates silver nanoparticles and radical polymerization

Journal of Pharmaceutical Sciences

Volumn 103, Issue 10, 2014, Pages 3244-3253

  Boonkaew, Benjawan ^a   Barber, Philip M ^b   Rengpipat, Sirirat ^c   Supaphol, Pitt ^c   Kempf, Margit ^b   He, Jibao ^a   John, Vijay T ^a   Cuttle, Leila ^b,d  

^a Tulane University   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c CHULALONGKORN UNIVERSITY   (Thailand)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Antimicrobial activity; Burn wounds; Cell culture; Dressings; Gamma irradiation; Hydrogels; Nanoparticles; Polymer synthesis; Silver; Spectroscopy

Indexed keywords

ANTIINFECTIVE AGENT; HYDROGEL; METAL NANOPARTICLE; SILVER;

BANDAGE; CHEMISTRY; GAMMA RADIATION; HYDROGEL; POLYMERIZATION;

ANTI-BACTERIAL AGENTS; BANDAGES; GAMMA RAYS; HYDROGELS; METAL NANOPARTICLES; POLYMERIZATION; SILVER;

EID: 84930154345     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24095     Document Type: Article

References (37)

1. Silvestry-Rodriguez N, Sicairos-Ruelas EE, Gerba CP, Bright KR.2007. Silver as a disinfectant. Rev Environ Contam Toxicol 191:23-45.
2. Moyer CA, Brentano L, Gravens DL, Margraf HW, Monafo WW Jr.1965. Treatment of large human burns with 0.5 percent silver nitrate solution. Arch Surg 90:812-867.
3. Fox CL Jr. 1968. Silver sulfadiazine-a new topical therapy for Pseudomonas burns. Arch Surg 96:184-188.
4. Fox CL Jr, Modak S. 1974. Mechanism of silver sulfadiazine action on burn wound infections. Antimicrob Agents Chemother 5:582-588.
5. Guggenbichler JP, Boswald M, Lugauer S, Krall T. 1999. A new technology of microdispersed silver in polyurethane induces antimicrobial activity in central venous catheters. Infection 27:S16-S23.
6. Dunn K. Edwards-Jones V. 2004. The role of Acticoat with nanocrystalline silver in the management of burns. Burns 30:S1-S9.
7. Gordon O, Vig Slenters T, Brunetto PS, Villaruz AE, Sturdevant DE, Otto M, Landmann R, Fromm KM. 2010. Silver coordination polymers for prevention of implant infection: Thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction. Antimicrob Agents Chemother 54:4208-4218.
8. Yakabe Y, Sano T, Ushio H, Yasunaga T. 1980. Kinetic studies of the interaction between silver ion and deoxyribonucleic acid. Chem Lett 4:373-376.
9. Yin HQ, Langford R, Burrell RE. 1999. Comparative evaluation of the antimicrobial activity of ACTICOAT antimicrobial barrier dressing. J Burn Care Rehabil 20:195-200.
10. Rai M, Yadav A, Gade A. 2009. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv 27:76-83.
11. Fong J. Wood F. 2006. Nanocrystalline silver dressings in wound management: A review. Int J Nanomed 1:441-449.
12. Ong SY, Wu J, Moochhala SM, Tan MH, Lu J. 2008. Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials 29:4323-4332.
13. Jain J, Arora S, Rajwade JM, Omray P, Khandelwal S, Paknikar KM. 2009. Silver nanoparticles in therapeutics: Development of an antimicrobial gel formulation for topical use. Mol Pharm 6:1388-1401.
14. Martinez-Castanon GA, Nino-martinez N, Martinez-Gutierrez F, Martinez-Mendoza JR, Ruiz F. 2008. Synthesis and antibacterial activity of silver nanoparticles with different sizes. JNanopart Res 10:1343-1348.
15. Oza G, Pandey S, Shah R, Sharon M. 2012. Extracellular fabrication of silver nanoparticles using pseudomonas aeruginosa and its antimicrobial Assay. Adv Appl Sci Res 3:1776-1783.
16. Egger S, Lehmann RP, Height MJ, Loessner MJ, Schuppler M.2009. Antimicrobial properties of a novel silver-silica nanocomposite material. Appl Environ Microbiol 75:2973-2976.
17. Reidy B, Andreas H, Luch A, Dawson KA, Lynch I. 2013. Mechanisms of silver nanoparticle release, transformation and toxicity: A critical review of current knowledge and recommendations for future studies and applications. Materials 6:2295-2350.
18. Li Q, Mahendra S, Lyon DY, Brunet L, Liga MV, Li D, Alvarez PJ.2008. Antimicrobial nanomaterials for water disinfection and microbial control: Potential applications and implications. Water Res 42:4591-4602.
19. Witthayaprapakorn C. 2011. Design and preparation of synthetic hydrogels via photopolymerisation for biomedical use as wound dressings. Procedia Eng 8:286-291.
20. Silindir M, Ozer AY. 2009. Sterilization methods and the comparison of e-beam sterilization with gamma radiation sterilization. FABAD J Pharm Sci 34:43-53.
21. Boonkaew B, Kempf M, Kimble R, Supaphol P, Cuttle L. 2014.Antimicrobial efficacy of a novel silver hydrogel dressing compared to two common silver burn wound dressings: ActicoatTM and PolyMem Silver ® . Burns 40:89-96.
22. Boonkaew B, Margit K, Kimble R, Supaphol P, Cuttle L. 2014.Cytotoxicity testing of silver-containing burn treatments using primary and immortal skin cells. Burns.[Epub ahead of print, doi: 10.1016/j.burns.2014.02.009]
23. Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T. 1990. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res 24:721-734.
24. Arya A, Sharma V, Pathak K. 2013. Pharmaceutical evaluation and dynamic vapor sorption studies of fast dissolving intraoral films of Loratadine. Pharm Dev Tech 18:1329-1338.
25. International Organizatin for Standardization. 2009. International standard ISO10993-5, biological evaluation of medical devices-Part 5: Test for in vitro cytotoxicity. ISO: 24-28.
26. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
27. Clinical and Laboratory Standards Institute. 2005. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria; proposed guideline. CLSI document M45-P. Pennsylvania: Clinical and Laboratory Standards Institute.
28. Bowler PG, Duerden BI, Armstrong DG. 2001.Wound microbiology and associated approaches to wound management. Clin Microbiol Rev 14:244-269.
29. Cuttle L, Kempf M, Phillips GE, Mill J, HayesMT, Fraser JF,Wang XQ, Kimble RM. 2006. A porcine deep dermal partial thickness burn model with hypertrophic scarring. Burns 32:806-820.
30. Zheng J, Clogston JD, Patri AK, Dobrovolskaia MA, McNeil SE.2011. Sterilization of silver nanoparticles using standard gamma irradiation procedure affects particle integrity and biocompatibility. J Nanomed Nanotechnol S5:001.
31. Li T, Park HG, Choi SH. 2007. (-Irradiation-induced preparation of Ag and Au nanoparticles and their characterizations. Mater Chem Phys 105:325-330.
32. Rattanaruengsrikul V, Pimpha N, Supaphol P. 2009. Development of gelatin hydrogel pads as antibacterial wound dressings. Macromol Biosci 9:1004-1015.
33. Babu AC, Prabhakar MN, Babu AS, Mallikarjuna B, Subha MCS, Rao KC. 2014. Development and characterization of semi-IPN silver nanocomposite hydrogels for antibacterial applications. Int J Carbohydr Chem.[Epub ahead of print]
34. Nilsson GE. 1997. On the measurement of evaporative water loss, method and clinical application. Dotoral thesis. Dept of Medical Engineering, University of Linkoping, Linkoping, Sweden
35. Hoellman DB, Pankuch GA, Appelbaum PC. 2004. Antistaphylococcal activity of CB-181963 (CAB-175), an experimental parenteral cephalosporin. Antimicrob Agents Chemother 48:4037-4039.
36. Wang L, Luo J, Shan S, Crew E, Yin J, Zhong CJ. 2011. Bacterial inactivation using silver-coated magnetic nanoparticles as functional antimicrobial agents. Anal Chem 83:8688-8695.
37. Arvidsson R, Molander S, Sanden BA. 2011. Impacts of a silvercoated future. J Ind Ecol 15:844-854.