Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot study

Veterinary Immunology and Immunopathology

Volumn 166, Issue 1-2, 2015, Pages 8-21

  Jonsdottir, Sigridur ^a   Hamza, Eman ^b   Janda, Jozef ^b   Rhyner, Claudio ^c   Meinke, Andreas ^d   Marti, Eliane ^b   Svansson, Vilhjalmur ^a   Torsteinsdottir, Sigurbjorg ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

^b UNIVERSITY OF BERN   (Switzerland)

^c SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^d Valneva Austria GmbH   (Austria)

Author keywords

Horse; IgG subclasses; Immunotherapy; Insect bite hypersensitivity; Intradermal; Intralymphatic

Indexed keywords

ADJUVANT; IC 31; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN G5; IMMUNOGLOBULIN G7; INTERLEUKIN 10; INTERLEUKIN 4; RECOMBINANT ALLERGEN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; ALLERGEN; DRUG COMBINATION; IC31 ADJUVANT; IMMUNOGLOBULIN G; OLIGODEOXYRIBONUCLEOTIDE; OLIGOPEPTIDE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CULICOIDES; ENZYME LINKED IMMUNOSORBENT ASSAY; ICELANDIC HORSE; IMMUNE RESPONSE; IMMUNOBLOTTING; IMMUNOTHERAPY; INSECT BITE HYPERSENSITIVITY; INTRACUTANEOUS TEST; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEROLOGY; SKIN ALLERGY; VACCINATION; ANIMAL; BLOOD; CLASSIFICATION; DRUG COMBINATION; HORSE; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOLOGY; INSECT BITE; PILOT STUDY;

CHIRONOMIDAE; CULICOIDES NUBECULOSUS; EQUIDAE; HEXAPODA;

ALLERGENS; ANIMALS; DRUG COMBINATIONS; HORSES; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOGLOBULIN G; INSECT BITES AND STINGS; OLIGODEOXYRIBONUCLEOTIDES; OLIGOPEPTIDES; PILOT PROJECTS; RECOMBINANT PROTEINS;

EID: 84930087378     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2015.05.002     Document Type: Article

References (65)

1. Anderson G.S., Belton P., Kleider N. Hypersensitivity of horses in British Columbia to extracts of native and exotic species of Culicoides (Diptera: Ceratopogonidae). J. Med. Entomol. 1993, 30(4):657-663.
2. Anderson G.S., Belton P., Jahren E., Lange H., Kleider N. Immunotherapy trial for horses in British Columbia with Culicoides (Diptera: Ceratopogonidae) hypersensitivity. J. Med. Entomol. 1996, 33(3):458-466.
3. Barbet J.L., Bevier D., Greiner E.C. Specific immunotherapy in the treatment of Culicoides hypersensitive horses: a double-blind study. Equine Vet. J. 1990, 22(4):232-235.
4. Baselgia S., Doherr M.G., Mellor P., Torsteinsdottir S., Jermann T., Zurbriggen A., Jungi T., Marti E. Evaluation of an in vitro sulphidoleukotriene release test for diagnosis of insect bite hypersensitivity in horses. Equine Vet. J. 2006, 38(1):40-46.
5. Bjornsdottir S., Sigvaldadottir J., Brostrom H., Langvad B., Sigurdsson A. Summer eczema in exported Icelandic horses: influence of environmental and genetic factors. Acta Vet. Scand. 2006, 48:3.
6. Briggs D.J., Banzhoff A., Nicolay U., Sirikwin S., Dumavibhat B., Tongswas S., Wasi C. Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine. Bull. World Health Organ. 2000, 78(5):693-698.
7. Bröstrom H., Larsson A., Troedsson M. Allergic dermatitis (sweet itch) of Icelandic horses in Sweden: an epidemiological study. Equine Vet. J. 1987, 19(3):229-236.
8. Calvo E., Mans B.J., Andersen J.F., Ribeiro J.M. Function and evolution of a mosquito salivary protein family. J. Biol. Chem. 2006, 281(4):1935-1942.
9. Cavkaytar O., Akdis C.A., Akdis M. Modulation of immune responses by immunotherapy in allergic diseases. Curr. Opin. Pharmacol. 2014, 17c:30-37.
10. Combadiere B., Liard C. Transcutaneous and intradermal vaccination. Hum Vaccines 2011, 7(8):811-827.
11. Doucoure S., Cornelie S., Patramool S., Mouchet F., Demettre E., Seveno M., Dehecq J.S., Rutee H., Herve J.P., Favier F., Misse D., Gasque P., Remoue F. First screening of Aedes albopictus immunogenic salivary proteins. Insect Mol. Biol. 2013, 22(4):411-423.
12. Fadok V.A., Greiner E.C. Equine insect hypersensitivity: skin test and biopsy results correlated with clinical data. Equine Vet. J. 1990, 22(4):236-240.
13. Fitzhugh D.J., Lockey R.F. Allergen immunotherapy: a history of the first 100 years. Curr. Opin. Allergy Clin. Immunol. 2011, 11(6):554-559.
14. Focke-Tejkl M., Weber M., Niespodziana K., Neubauer A., Huber H., Henning R., Stegfellner G., Maderegger B., Hauer M., Stolz F., Niederberger V., Marth K., Eckl-Dorna J., Weiss R., Thalhamer J., Blatt K., Valent P., Valenta R. Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy. J. Allergy Clin. Immunol. 2014, [Epub ahead of print].
15. Ginel P.J., Hernandez E., Lucena R., Blanco B., Novales M., Mozos E. Allergen-specific immunotherapy in horses with insect bite hypersensitivity: a double-blind, randomized, placebo-controlled study. Vet. Dermatol. 2014, 25(1):29-e10.
16. Goehring L.S., Wagner B., Bigbie R., Hussey S.B., Rao S., Morley P.S., Lunn D.P. Control of EHV-1 viremia and nasal shedding by commercial vaccines. Vaccine 2010, 28(32):5203-5211.
17. Goodman L.B., Wimer C., Dubovi E.J., Gold C., Wagner B. Immunological correlates of vaccination and infection for equine herpesvirus 1. Clin. Vaccine Immunol. 2012, 19(2):235-241.
18. Halldordsottir S., Larsen H.J. An epidemiological study of summer eczema in Icelandic horses in Norway. Equine Vet. J. 1991, 23(4):296-299.
19. Hamza E., Doherr M.G., Bertoni G., Jungi T., Marti E. Modulation of allergy incidence in Icelandic horses is associated with a change in IL-4-producing T cells. Int. Arch. Allergy Immunol. 2007, 144(4):325-337.
20. Hamza E., Wagner B., Jungi T.W., Mirkovitch J., Marti E. Reduced incidence of insect-bite hypersensitivity in Icelandic horses is associated with a down-regulation of interleukin-4 by interleukin-10 and transforming growth factor-β1. Vet. Immunol. Immunopathol. 2008, 122(1-2):65-75.
21. Hamza E., Torsteinsdottir S., Eydal M., Frey C., Mirkovitch J., Brcic M., Wagner B., Wilson A., Jungi T., Marti E. Increased IL-4 and decreased regulatory cytokine production following relocation of Icelandic horses from a high to low endoparasite environment. Vet. Immunol. Immunopathol. 2010, 133(1):40-50.
22. Hamza E., Akdis C.A., Wagner B., Steinbach F., Marti E. In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity. Clin. Exp. Allergy 2013, 43(8):889-901.
23. Hamza E., Mirkovitch J., Steinbach F., Marti E. Regulatory T cells in early life: comparative study of CD4(+)CD25(high) T cells from foals and adult horses. PLOS ONE 2015, 10(3):e0120661.
24. Heimann M., Janda J., Sigurdardottir O.G., Svansson V., Klukowska J., von Tscharner C., Doherr M., Broström H., Andersson L.S., Einarsson S., Marti E., Torsteinsdottir S. Skin-infiltrating T cells and cytokine expression in Icelandic horses affected with insect bite hypersensitivity: a possible role for regulatory T cells. Vet. Immunol. Immunopathol. 2011, 140(1-2):63-74.
25. Hellberg W., Wilson A., Mellor P., Doherr M., Torsteinsdottir S., Zurbriggen A., Jungi T., Marti E. Equine insect bite hypersensitivity: immunoblot analysis of IgE and IgG subclass responses to Culicoides nubeculosus salivary gland extract. Vet. Immunol. Immunopathol. 2006, 113(1-2):99-112.
26. Johannsson V. The life cycles of Simulium vittatum Zett. in Icelandic lake-outlets. Verh. Int. Verein Limnol. 1988, 23:2170-2178.
27. Keggan A., Freer H., Rollins A., Wagner B. Production of seven monoclonal equine immunoglobulins isotyped by multiplex analysis. Vet. Immunol. Immunopathol. 2013, 153(3-4):187-193.
28. Kenney R.T., Frech S.A., Muenz L.R., Villar C.P., Glenn G.M. Dose sparing with intradermal injection of influenza vaccine. N. Engl. J. Med. 2004, 351(22):2295-2301.
29. King T.P., Spangfort M.D. Structure and biology of stinging insect venom allergens. Int. Arch. Allergy Immunol. 2000, 123(2):99-106.
30. Langner K.F., Jarvis D.L., Nimtz M., Heselhaus J.E., McHolland L.E., Leibold W., Drolet B.S. Identification, expression and characterisation of a major salivary allergen (Cul s 1) of the biting midge Culicoides sonorensis relevant for summer eczema in horses. Int. J. Parasitol. 2009, 39(2):243-250.
31. Lanz S., Gerber V., Marti E., Rettmer H., Klukowska-Rotzler J., Gottstein B., Matthews J.B., Pirie S., Hamza E. Effect of hay dust extract and cyathostomin antigen stimulation on cytokine expression by PBMC in horses with recurrent airway obstruction. Vet. Immunol. Immunopathol. 2013, 155(4):229-237.
32. Larche M., Akdis C.A., Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat. Rev. Immunol. 2006, 6(10):761-771.
33. Lewis M.J., Wagner B., Woof J.M. The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies. Mol. Immunol. 2008, 45(3):818-827.
34. ® and IC30, novel types of vaccine adjuvant based on peptide delivery systems. Expert Rev. Vaccines 2007, 6(5):741-746.
35. Lopez A.M., Hines M.T., Palmer G.H., Alperin D.C., Hines S.A. Identification of pulmonary T-lymphocyte and serum antibody isotype responses associated with protection against Rhodococcus equi. Clin. Diagn. Lab. Immunol. 2002, 9(6):1270-1276.
36. Marti E., Urwyler A., Neuenschwander M., Eicher R., Meier D., de Weck A.L., Gerber H., Lazary S., Dahinden C.A. Sulfidoleukotriene generation from peripheral blood leukocytes of horses affected with insect bite dermal hypersensitivity. Vet. Immunol. Immunopathol. 1999, 71(3-4):307-320.
37. Marti E., Gerber V., Wilson A.D., Lavoie J.P., Horohov D., Crameri R., Lunn P., Antczak D., Björnsdóttir S., Björnsdóttir T.S., Cunningham F., Dérer M., Frey R., Hamza E., Horin P., Heimann M., Kolm-Stark G., Ólafsdóttir G., Ramery E., Russell C., Schaffartzik A., Svansson V., Torsteinsdóttir S., Wagner B. Report of the 3rd Havemeyer Workshop on Allergic Diseases of the Horse, Holar, Iceland, June 2007. Vet. Immunol. Immunopathol. 2008, 126:351-361.
38. Nelson K.M., Schram B.R., McGregor M.W., Sheoran A.S., Olsen C.W., Lunn D.P. Local and systemic isotype-specific antibody responses to equine influenza virus infection versus conventional vaccination. Vaccine 1998, 16(13):1306-1313.
39. Olafsdottir T.A., Lingnau K., Nagy E., Jonsdottir I. Novel protein-based pneumococcal vaccines administered with the Th1-promoting adjuvant IC31 induce protective immunity against pneumococcal disease in neonatal mice. Infect. Immun. 2012, 80(1):461-468.
40. Ozdemir C., Kucuksezer U.C., Akdis M., Akdis C.A. Mechanisms of immunotherapy to wasp and bee venom. Clin. Exp. Allergy 2011, 41(9):1226-1234.
41. Pattacini L., Mize G.J., Graham J.B., Fluharty T.R., Graham T.M., Lingnau K., Wizel B., Perdiguero B., Esteban M., Pantaleo G., Shen M., Spies G.A., McElrath M.J., Lund J.M. A novel HIV vaccine adjuvanted by IC31 induces robust and persistent humoral and cellular immunity. PLoS ONE 2012, 7(7):25.
42. Peeters L.M., Janssens S., Goddeeris B.M., De Keyser K., Wilson A.D., Kaufmann C., Schaffartzik A., Marti E., Buys N. Evaluation of an IgE ELISA with Culicoides spp. extracts and recombinant salivary antigens for diagnosis of insect bite hypersensitivity in Warmblood horses. Vet. J. 2013, 198(1):141-147.
43. Quinn P.J., Baker K.P., Morrow A.N. Sweet itch: responses of clinically normal and affected horses to intradermal challenge with extracts of biting insects. Equine Vet. J. 1983, 15(3):266-272.
44. Redfield R.R., Innis B.L., Scott R., Cannon H.G., Bancroft W.H. Clinical evaluation of low-dose intradermally administered hepatitis b virus vaccine: a cost reduction strategy. JAMA 1985, 254(22):3203-3206.
45. Schaffartzik A., Marti E., Crameri R., Rhyner C. Cloning, production and characterization of antigen 5 like proteins from Simulium vittatum and Culicoides nubeculosus, the first cross-reactive allergen associated with equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 2010, 137(1-2):76-83.
46. Schaffartzik A., Marti E., Torsteinsdottir S., Mellor P.S., Crameri R., Rhyner C. Selective cloning, characterization, and production of the Culicoides nubeculosus salivary gland allergen repertoire associated with equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 2011, 139(2-4):200-209.
47. Schaffartzik A., Hamza E., Janda J., Crameri R., Marti E., Rhyner C. Equine insect bite hypersensitivity: what do we know?. Vet. Immunol. Immunopathol. 2012, 147(3-4):113-126.
48. Schellack C., Prinz K., Egyed A., Fritz J.H., Wittmann B., Ginzler M., Swatosch G., Zauner W., Kast C., Akira S., von Gabain A., Buschle M., Lingnau K. IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses. Vaccine 2006, 24(26):5461-5472.
49. Senti G., Johansen P., Kündig T.M. Intralymphatic immunotherapy. Curr. Opin. Allergy Clin. Immunol. 2009, 9(6):537-543.
50. Senti G., Johansen P., Kündig T.M. Intralymphatic immunotherapy: from the rationale to human applications. Curr. Top. Microbiol. Immunol. 2011, 352:71-84.
51. Sheoran A.S., Sponseller B.T., Holmes M.A., Timoney J.F. Serum and mucosal antibody isotype responses to M-like protein (SeM) of Streptococcus equi in convalescent and vaccinated horses. Vet. Immunol. Immunopathol. 1997, 59(3-4):239-251.
52. Soboll G., Horohov D.W., Aldridge B.M., Olsen C.W., McGregor M.W., Drape R.J., Macklin M.D., Swain W.F., Lunn D.P. Regional antibody and cellular immune responses to equine influenza virus infection, and particle mediated DNA vaccination. Vet. Immunol. Immunopathol. 2003, 94(1-2):47-62.
53. Soboll Hussey G., Hussey S.B., Wagner B., Horohov D.W., Van de Walle G.R., Osterrieder N., Goehring L.S., Rao S., Lunn D.P. Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant. Vet. Res. 2011, 42:23.
54. Soldatova L.N., Crameri R., Gmachl M., Kemeny D.M., Schmidt M., Weber M., Mueller U.R. Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia coli. J. Allergy Clin. Immunol. 1998, 101(5):691-698.
55. Sommer-Locher B., Endriss V., Fromm E. Various circumstances regarding initial allergen exposure and their influence on development of insect bite hypersensitivity in horses. J. Equine Vet. Sci. 2012, 32(3):158-163.
56. Svansson V., Roelse M., Olafsdottir G., Thorsteinsdottir L., Torfason E.G., Torsteinsdottir S. Immune response against equine gammaherpesvirus in Icelandic horses. Vet. Microbiol. 2009, 137(3-4):363-368.
57. ® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs. PLOS ONE 2013, 8(2).
58. Townley P., Baker K.P., Quinn P.J. Preferential landing and engorging sites of Culicoides species landing on a horse in Ireland. Equine Vet. J. 1984, 16(2):117-120.
59. Valenzuela J.G., Charlab R., Gonzalez E.C., De Miranda-Santos I.K.F., Marinotti O., Francischetti I.M.B., Ribeiro J.M.C. The D7 family of salivary proteins in blood sucking diptera. Insect Mol. Biol. 2002, 11(2):149-155.
60. van der Meide N.M.A., Roders N., Sloet van Oldruitenborgh-Oosterbaan M.M., Schaap P.J., van Oers M.M., Leibold W., Savelkoul H.F.J., Tijhaar E. Cloning and expression of candidate allergens from Culicoides obsoletus for diagnosis of insect bite hypersensitivity in horses. Vet. Immunol. Immunopathol. 2013, 153(3-4):227-239.
61. ® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers. Vaccine 2010, 28(20):3571-3581.
62. Wagner B., Miller D.C., Lear T.L., Antczak D.F. The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse. J. Immunol. 2004, 173(5):3230-3242.
63. Wagner B. Immunoglobulins and immunoglobulin genes of the horse. Dev. Comp. Immunol. 2006, 30(1-2):155-164.
64. Wilson A.D., Harwood L.J., Bjornsdottir S., Marti E., Day M.J. Detection of IgG and IgE serum antibodies to Culicoides salivary gland antigens in horses with insect dermal hypersensitivity (sweet itch). Equine Vet. J. 2001, 33(7):707-713.
65. Wilson A.D., Harwood L., Torsteinsdottir S., Marti E. Production of monoclonal antibodies specific for native equine IgE and their application to monitor total serum IgE responses in Icelandic and non-Icelandic horses with insect bite dermal hypersensitivity. Vet. Immunol. Immunopathol. 2006, 112(3-4):156-170.