Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: A phase 3b, open-label, non-inferiority, randomised trial

The Lancet

Volumn 385, Issue 9982, 2015, Pages 2077-2087

  Goldstein, Joshua N ^a   Refaai, Majed A ^b   Milling, Truman J ^c   Lewis, Brandon ^d   Goldberg Alberts, Robert ^e   Hug, Bruce A ^e   Sarode, Ravi ^f  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^e CSL Behring LLC   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVITAMIN K; PROTHROMBIN COMPLEX; VITAMIN K GROUP; BLOOD CLOTTING FACTOR; HEMOSTATIC AGENT; PROTHROMBIN COMPLEX CONCENTRATES;

ADULT; ARTICLE; BLEEDING; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEALTH CARE NEED; HEMOSTASIS; HUMAN; HYPERVOLEMIA; INTERMETHOD COMPARISON; INTERNATIONAL NORMALIZED RATIO; INVASIVE PROCEDURE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 3 CLINICAL TRIAL; PLASMA TRANSFUSION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURGICAL TECHNIQUE; THROMBOEMBOLISM; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; AGED; ANALYSIS OF VARIANCE; ANTAGONISTS AND INHIBITORS; BLOOD LOSS, SURGICAL; CLINICAL TRIAL; COMPARATIVE STUDY; PLASMA; PREOPERATIVE CARE; PROCEDURES;

AGED; ANALYSIS OF VARIANCE; BLOOD COAGULATION FACTORS; BLOOD LOSS, SURGICAL; FEMALE; HEMOSTASIS, SURGICAL; HEMOSTATICS; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; PLASMA; PREOPERATIVE CARE; TREATMENT OUTCOME; VITAMIN K;

EID: 84930085408     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)61685-8     Document Type: Article

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