A follow-up of a randomised study of metformin and insulin in gestational diabetes mellitus: Growth and development of the children at the age of 18 months

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 122, Issue 7, 2015, Pages 994-1000

  Ijas H ^a   Vaarasmaki M ^a   Saarela, T ^a   Keravuo, R ^b   Raudaskoski, T ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b KAINUU CENTRAL HOSPITAL   (Finland)

Author keywords

Gestational diabetes mellitus; metformin; offspring

Indexed keywords

INSULIN; METFORMIN; ANTIDIABETIC AGENT;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHILD; CHILD DEVELOPMENT; CHILD GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; FEMALE; HEAD CIRCUMFERENCE; HUMAN; INCIDENCE; INFANT; LANGUAGE DELAY; LANGUAGE DEVELOPMENT; MALE; MOTOR DEVELOPMENT; MOTOR DYSFUNCTION; OBESITY; PREGNANCY DIABETES MELLITUS; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOCIAL EVOLUTION; DIABETES, GESTATIONAL; FOLLOW UP; PHYSIOLOGY; PREGNANCY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADULT; BODY HEIGHT; BODY WEIGHT; CHILD DEVELOPMENT; DIABETES, GESTATIONAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOGLYCEMIC AGENTS; INFANT; INSULIN; MALE; METFORMIN; PREGNANCY; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84930045017     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/1471-0528.12964     Document Type: Article

References (26)

1. Gestational Diabetes in the United States. 2011 [ http://diabetes.niddk.nih.gov/dm/pubs/statistics ]. Accessed 2 April 2014.
2. THL National Institute for Health and Welfare, Finland. Medical Birth Register at THL National Institute for Health and Welfare Finland. 2013 [ www.thl.fi/en/statistics/parturients ]. Accessed 2 April 2014.
3. Rowan JA, Hague WM, Gao W, Battin MR, Moore MP,. MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008; 358: 2003-15.
4. Ijas H, Vaarasmaki M, Morin-Papunen L, Keravuo R, Ebeling T, Saarela T, et al., Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study. BJOG 2011; 118: 880-885.
5. Niromanesh S, Alavi A, Sharbaf FR, Amjadi N, Moosavi S, Akbari S,. Metformin compared with insulin in the management of gestational diabetes mellitus: a randomized clinical trial. Diabetes Res Clin Pract 2012; 98: 422-9.
6. Tertti K, Ekblad U, Koskinen P, Vahlberg T, Ronnemaa T,. Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin. Diabetes Obes Metab 2013; 15: 246-51.
7. Mesdaghinia E, Samimi M, Homaei Z, Saberi F, Moosavi SG, Yaribakht M,. Comparison of newborn outcomes in women with gestational diabetes mellitus treated with metformin or insulin: a randomised blinded trial. Int J Prev Med 2013; 4: 327-33.
8. Spaulonci CP, Bernardes LS, Trindade TC, Zugaib M, Francisco RP,. Randomized trial of metformin vs insulin in the management of gestational diabetes. Am J Obstet Gynecol 2013; 209: 34.e1-7.
9. Vanky E, Zahlsen K, Spigset O, Carlsen SM,. Placental passage of metformin in women with polycystic ovary syndrome. Fertil Steril 2005; 83: 1575-8.
10. Charles B, Norris R, Xiao X, Hague W,. Population pharmacokinetics of metformin in late pregnancy. Ther Drug Monit 2006; 28: 67-72.
11. Kovo M, Haroutiunian S, Feldman N, Hoffman A, Glezerman M,. Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model. Eur J Obstet Gynecol Reprod Biol 2008; 136: 29-33.
12. Gilbert C, Valois M, Koren G,. Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis. Fertil Steril 2006; 86: 658-63.
13. Gutzin SJ, Kozer E, Magee LA, Feig DS, Koren G,. The safety of oral hypoglycemic agents in the first trimester of pregnancy: a meta-analysis. Can J Clin Pharmacol 2003; 10: 179-83.
14. Rowan JA, Rush EC, Obolonkin V, Battin M, Wouldes T, Hague WM,. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011; 34: 2279-84.
15. The Finnish sex spesific growth charts software. 2013 [ www.kasvukayrat.fi/kayra.html ]. Accessed 2 April 2014.
16. Working group appointed by the Finnish Paediatric Society. Obesity (children). Current care summary. 2012 [ www.kaypahoito.fi/web/kh/naytaartikkeli/tunnus/hoi50034 ]. Accessed 2 April 2014.
17. Carlsen SM, Martinussen MP, Vanky E,. Metformin's effect on first-year weight gain: a follow-up study. Pediatrics 2012; 130: e1222-6.
18. Graversen L, Sorensen TI, Petersen L, Sovio U, Kaakinen M, Sandbaek A, et al., Stability of the associations between early life risk indicators and adolescent overweight over the evolving obesity epidemic. PLoS One 2014; 9: e95314.
19. Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH,. Growth in utero and serum cholesterol concentrations in adult life. BMJ 1993; 307: 1524-7.
20. Catalano PM, Farrell K, Thomas A, Huston-Presley L, Mencin P, de Mouzon SH, et al., Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr 2009; 90: 1303-13.
21. HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: associations with neonatal anthropometrics. Diabetes 2009; 58: 453-9.
22. Boney CM, Verma A, Tucker R, Vohr BR,. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005; 115: e290-6.
23. Rowan JA, Gao W, Hague WM, McIntyre HD,. Glycemia and its relationship to outcomes in the metformin in gestational diabetes trial. Diabetes Care 2010; 33: 9-16.
24. Glueck CJ, Goldenberg N, Pranikoff J, Loftspring M, Sieve L, Wang P,. Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. Hum Reprod 2004; 19: 1323-30.
25. Scarpello JH, Howlett HC,. Metformin therapy and clinical uses. Diab Vasc Dis Res 2008; 5: 157-67.
26. Salomaki H, Vahatalo LH, Laurila K, Jappinen NT, Penttinen AM, Ailanen L, et al., Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood. PLoS One 2013; 8: e56594.