Transfusion therapy and alloimmunization in Thalassemia Intermedia: A 10 year experience at a tertiary care university hospital

Transfusion and Apheresis Science

Volumn 51, Issue 1, 2014, Pages 42-46

  Al Riyami, Arwa Z ^a   Al Mahrooqi, Sabah ^a   Al Hinai, Sumaiya ^a   Al Hosni, Saif ^a   Al Madhani, Ali ^b   Daar, Shahina ^c  

^a SULTAN QABOOS UNIVERSITY HOSPITAL   (Oman)

^b Sohar Hospital   (Oman)

^c SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

Alloimmunization; Phenotype; Thalassemia Intermedia; Transfusion

Indexed keywords

ANTIBODY; HYDROXYUREA;

ADOLESCENT; ADULT; ALLOIMMUNIZATION; ANEMIA; ARTICLE; BLOOD BANK; BLOOD TRANSFUSION; CHILD; CLINICAL ARTICLE; ERYTHROCYTE; FEMALE; HEALTH CARE POLICY; HUMAN; MALE; PHENOTYPE; PORTAL VEIN THROMBOSIS; PREGNANCY; SPLENECTOMY; TERTIARY CARE CENTER; THALASSEMIA INTERMEDIA; TREATMENT INDICATION; UNIVERSITY HOSPITAL; ADVERSE EFFECTS; BETA-THALASSEMIA; BLOOD; ERYTHROCYTE TRANSFUSION; IMMUNOLOGY; MIDDLE AGED; OMAN; PREGNANCY COMPLICATIONS, HEMATOLOGIC;

ADOLESCENT; ADULT; BETA-THALASSEMIA; CHILD; ERYTHROCYTE TRANSFUSION; FEMALE; HUMANS; MALE; MIDDLE AGED; OMAN; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; TERTIARY CARE CENTERS;

EID: 84930041196     PISSN: 14730502     EISSN: 18781683     Source Type: Journal    
DOI: 10.1016/j.transci.2014.04.009     Document Type: Article

References (18)

1. Taher Ali, Isma'eel Hussain, Cappellini Maria D. Thalassemia intermedia: revisited. Blood Cells Mol Dis 2006, 37:12-20.
2. Taher A.T., Cappellini M.D., Musallam Recent advances and treatment challenges in patients with non-transfusion-dependent thalassemia. Blood Rev April 2012, 26(Suppl 1):S1-S2.
3. Taher A.T., Musallamb K.M., Karimic M., et al. Contemporary approaches to treatment of beta-thalassemia intermedia. Blood Rev 2012, 26S:S24-S27.
4. Olivieri N.F. The beta-thalassemias. N Engl J Med 1999, 341:99-109.
5. Taher A.T., Musallam K.M., Cappellini M.D., et al. Optimal management of beta thalassaemia intermedia. Br J Haematol 2011, 152(5):512-523.
6. Spanos T., Karageorga M., Ladis V., et al. Red cell alloantibodies in patients with thalassemia. Vox Sang 1990, 58:50-55.
7. Blumberg N., Heal J.M., Gettings K.F. WBC reduction of RBC transfusions is associated with a decreased incidence of RBC alloimmunization. Transfusion 2003, 43:945-952.
8. Musallam K.M., Cappellini M.D., Taher A.T. Evaluation of the 5mg/g liver iron concentration threshold and its association with morbidity in patients with beta-thalassemia intermedia. Blood Cells Mol Dis June 2013, 51:35-38.
9. Anderson L.J., Holden S., Davis B., et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001, 22(23):2171-2179.
10. Borgna-Pignatti C. Modern treatment of thalassaemia intermedia. Br J Haematol 2007, 138(3):291-304.
11. Taher A.T., Musallam K.M., Karimi M., et al. Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study. Blood 2010, 115(10):1886-1892.
12. Chou S.T., Liem R.I., Thompson A.A. Challenges of alloimmunization in patients with haemoglobinopathies. Br J Haematol November 2012, 159(4):394-404.
13. Lasalle-Williams M., Nuss R., Le T., Cole L., Hassell K., Murphy J.R., et al. Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center. Transfusion 2011, 51:1732-1739.
14. Spanos T., Karageorga M., Ladis V., et al. Red cell alloantibodies in patients with thalassemia. Vox Sang 1990, 58:50-55.
15. Musallam K.M., Rivella S., Vichinsky E., et al. Non-transfusion-dependent thalassemias. Haematologica 2013, 98(6):833-844.
16. Levy A., Fraser D., Katz M., Mazor M., Sheiner E. Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol 1 October 2005, 122(2):182-186.
17. Thompson A.A., Cunningham M.J., Singer S.T., et al. Red cell alloimmunization in a diverse population of transfused patients with thalassaemia. Br J Haematol 2011, 153:121-128.
18. Taher A, Vichinsky E, Musallam K, et al. Guidelines for the management of non transfusion dependent thalassaemia (NTDT). In: Thalassemia international federation 2013, <>. p. 14. http://www.thalassaemia.org.cy/wordpress/wp-content/uploads/2013/05/NTDT-BOOKLET-FINAL-PDF.pdf.