WBC reduction of RBC transfusions is associated with a decreased incidence of RBC alloimmunization

Transfusion

Volumn 43, Issue 7, 2003, Pages 945-952

  Blumberg, Neil ^a   Heal, Joanna M ^b   Gettings, Kelly F ^b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ALLOIMMUNIZATION; ANTIBODY SCREENING; ARTICLE; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; HUMORAL IMMUNITY; INCIDENCE; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; TH2 CELL; THROMBOCYTE;

BLOOD COMPONENT REMOVAL; BLOOD GROUP ANTIGENS; BLOOD GROUP INCOMPATIBILITY; COHORT STUDIES; ERYTHROCYTE TRANSFUSION; FEMALE; HUMANS; ISOANTIBODIES; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKOCYTES; MALE; PREGNANCY; RETROSPECTIVE STUDIES; RH-HR BLOOD-GROUP SYSTEM; SEX CHARACTERISTICS; TH2 CELLS;

EID: 0038307146     PISSN: 00411132     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1537-2995.2003.00443.x     Document Type: Article

References (26)

1. Mollison PL, Engelfriet CP, Contreras M. Blood transfusion in clinical medicine, 10th ed. Oxford: Blackwell, 1997.
2. Janeway CA, Travers P, Walport M, Shlomchik M. Immunobiology, 5th ed. Hamden, CT: Garland Press, 2001.
3. Matzinger P. Tolerance, danger, and the extended family (review). Annu Rev Immunol 1994;12:991-1045.
4. Mosmann TR, Sad S. The expanding universe of T-cell subsets. Th1, Th2, and more. Immunol Today 1996;17:138-46.
5. Romagnani S. Th1 and Th2 in human diseases. Clin Immunol Immunopathol 1996;80:225-35.
6. Kirkley SA, Cowles J, Pellegrini VD Jr, et al. Cytokine secretion after allogeneic or autologous blood transfusion. Lancet 1995;345:527.
7. Babcock GF, Alexander JW. The effects of blood transfusion on cytokine production by Th1 and Th2 lymphocytes in the mouse. Transplantation 1996;61:465-8.
8. Kirkley SA, Cowles J, Pellegrini VD Jr, et al. Blood transfusion and total joint replacement surgery: T helper 2 (Th2) cytokine secretion and clinical outcome. Transfusion Med 1998;8:195-204.
9. Blumberg N, Heal JM. The transfusion immunomodulation theory: the Th1/Th2 paradigm and an analogy with pregnancy as a unifying mechanism. Seminars Hematol 1996;33:329-40.
10. Blumberg N, Heal JM. Transfusion immunomodulation. In: Anderson KC, Ness PM, eds. Scientific basis of transfusion medicine, 2nd ed. Philadelpha PA: W.B. Saunders, 2000:427-43.
11. Vamvakas EC, Blajchman MA. Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction? Blood 2001;97:1180-95.
12. Deeg HJ, Aprile J, Storb R, et al. Functional dendritic cells are required for transfusion-induced sensitization in canine marrow graft recipients. Blood 1988;71:1138-40.
13. Henn V, Slupsky JR, Grafe M, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998;391:591-4.
14. Phipps RP, Kaufman J, Blumberg N. Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet 2001;357:2023-4.
15. + T-cell responses. Immunol Today 1996;17:410-4.
16. Zhang Y, Cao HI, Graf B, et al. CD40 engagement upregulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts. J Immunol 1998;160:1053-7.
17. Blumberg N, Peck K, Ross K, Avila E. Immune response to chronic red blood cell transfusion. Vox Sang 1983;44:212-7.
18. Singer ST, Wu V, Mignacca R, et al. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent. Blood 2000;96:3369-73.
19. Mills CD, Kincaid K, Alt IM, Heilman MI, Hill AM. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol 2000;164:6166-73.
20. Dong C, Flavell RA. Th1 and Th2 cells. Curr Opin Hematol 2001;8:47-51.
21. Romagnani S. T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol 2000;85:9-18.
22. Blajchman MA, Bardossy L, Carmen R, et al. Allogeneic blood transfusion-induced enhancement of tumor growth: two animal models showing amelioration by leukodepletion and passive transfer using spleen cells. Blood 1993;81:1880-2.
23. Jensen LS, Kissmeyer-Nielsen P, Wolff B, Qvist N. Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgery. Lancet 1996;348:841-5.
24. Tartter PI, Mohandas K, Azar P, et al. Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery. Am J Surg 1998;176:462-6.
25. van de Watering LM, Hermans J, Houbiers JG, et al. Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: a randomized clinical trial. Circulation 1998;97:562-8.
26. Salonvaara M, Eronen J, Helminen P, et al. Small doses of cryopreserved O RhD positive leukocyte-reduced red cells are not effective in primary immunization of RhD negative voluntary men (abstract). Vox Sang 2002;83 (Suppl 2):65.