Rapid trimming of cell surface polysialic acid (PolySia) by exovesicular sialidase triggers release of preexisting surface neurotrophin

Journal of Biological Chemistry

Volumn 290, Issue 21, 2015, Pages 13202-13214

  Sumida, Mizuki ^a   Hane, Masaya ^a   Yabe, Uichiro ^a   Shimoda, Yasushi ^b   Pearce, Oliver M T ^c   Kiso, Makoto ^d   Miyagi, Taeko ^e   Sawada, Makoto ^a   Varki, Ajit ^c   Kitajima, Ken ^a   Sato, Chihiro ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGAOKA UNIVERSITY OF TECHNOLOGY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GIFU UNIVERSITY   (Japan)

^e TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CELL ADHESION; CELL CULTURE; CELL MEMBRANES; CELLS; CYTOLOGY; ENZYME INHIBITION; MAMMALS;

BRAIN-DERIVED NEUROTROPHIC FACTORS; CELL SURFACES; INFLAMMATORY STIMULI; MICROGLIAL CELLS; N-ACETYLNEURAMINIC ACID; N-GLYCOLYLNEURAMINIC ACID; POLYSIALIC ACID; SINGLE OXYGEN ATOM;

ACID RESISTANCE;

BRAIN DERIVED NEUROTROPHIC FACTOR; N GLYCOLOYLNEURAMINIC ACID; NEUROTROPHIN; OXYGEN; POLYSIALIC ACID; SIALIDASE; MESSENGER RNA; NERVE GROWTH FACTOR; SIALIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; ENZYME REGULATION; GLYCOSAMINOGLYCAN METABOLISM; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MEMBRANE; CYTOLOGY; ENZYMOLOGY; EXTRACELLULAR MATRIX; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; GLYCOCALYX; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); WESTERN BLOTTING;

SIA;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL MEMBRANE; CELLS, CULTURED; EXTRACELLULAR MATRIX; FLUORESCENT ANTIBODY TECHNIQUE; GLYCOCALYX; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICROGLIA; NERVE GROWTH FACTORS; NEURAMINIDASE; OXYGEN; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIALIC ACIDS;

EID: 84929998976     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.638759     Document Type: Article

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