Prokinetic effects of large-dose lubiprostone on gastrointestinal transit in dogs and its mechanisms

American Journal of Translational Research

Volumn 7, Issue 3, 2015, Pages 513-521

  Song, Jun ^a,c   Yin, Jieyun ^a   Xu, Xiaohong ^b   Chen, Jiande ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Ningbo Pace Translational Medical Research Center   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; LUBIPROSTONE; PLACEBO;

ANIMAL EXPERIMENT; ARTICLE; CANNULA; COLON CANNULA; CONTROLLED STUDY; DRUG MECHANISM; DUODENAL CANNULA; FEMALE; GASTRIC CANNULA; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; INTESTINE CONTRACTION; MANOMETRY; NONHUMAN; STOMACH ANTRUM; STOMACH EMPTYING; X RAY;

CANIS FAMILIARIS;

EID: 84929990167     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Higgins PD and Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004; 99: 750-759.
2. Talley NJ, Zinsmeister AR, Van Dyke C and Melton LJ, 3rd Epidemiology of colonic symptoms and the irritable bowel syndrome. Gastroenterology 1991; 101: 927-934.
3. Cuppoletti J, Malinowska DH, Tewari KP, Li QJ, Sherry AM, Patchen ML and Ueno R. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol 2004; 287: C1173-1183.
4. Gale JD. The use of novel promotility and prosecretory agents for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. Adv Ther 2009; 26: 519-530.
5. Bassil AK, Borman RA, Jarvie EM, McArthur-Wilson RJ, Thangiah R, Sung EZ, Lee K and Sanger GJ. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol 2008; 154: 126-135.
6. Cuppoletti J, Malinowska DH, Chakrabarti J and Ueno R. Effects of lubiprostone on human uterine smooth muscle cells. Prostaglandins Other Lipid Mediat 2008; 86: 56-60.
7. Yin J and Chen J. Excitatory effects of synchronized intestinal electrical stimulation on small intestinal motility in dogs. Am J Physiol Gastrointest Liver Physiol 2007; 293: G1190-1195.
8. Xu J and Chen JD. Effects of cyclooxygenase-2 inhibitor on glucagon-induced delayed gastric emptying and gastric dysrhythmia in dogs. Neurogastroenterol Motil 2007; 19: 144-151.
9. Chen J, Xing J and Chen JD. Effects of muscarinic receptor stimulation and nitric oxide synthase inhibition on gastric tone and gastric myoelectrical activity in canines. J Gastroe-nterol Hepatol 2009; 24: 1130-1135.
10. Chen J, Koothan T and Chen JD. Synchronized gastric electrical stimulation improves vagotomy-induced impairment in gastric accommodation via the nitrergic pathway in dogs. Am J Physiol Gastrointest Liver Physiol 2009; 296: G310-318.
11. Song J, Yin J and Chen JD. Acute and chronic effects of desvenlafaxine on gastrointestinal transit and motility in dogs. Neurogastroenterol Motil 2013; 25: 824-e637.
12. Chen J, Song GQ, Yin J, Koothan T and Chen JD. Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs. Am J Physiol Gastrointest Liver Physiol 2008; 295: G614-620.
13. Camilleri M, Bharucha AE, Ueno R, Burton D, Thomforde GM, Baxter K, McKinzie S and Zinsmeister AR. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol 2006; 290: G942-947.
14. Bethesda MD. AMITIZEA (lubiprostone): Phase I ADME Study. Sucompo pharmaceuticals, data on file 2006.
15. Qi H and Chen JD. Effects of intestinal electrical stimulation on postprandial small-bowel motility and transit in dogs. Am J Surg 2006; 192: e55-e60.
16. Xu X, Pasricha PJ, Sallam HS, Ma L and Chen JD. Clinical significance of quantitative assessment of rectoanal inhibitory reflex (RAIR) in patients with constipation. J Clin Gastroenterol 2008; 42: 692-698.
17. Yin J and Chen JD. Electroacupuncture improves rectal distension-induced delay in solid gastric emptying in dogs. Am J Physiol Regul Integr Comp Physiol 2011; 301: R465-472.
18. Ouyang H, Xing J and Chen J. Electroacupunc-ture restores impaired gastric accommodation in vagotomized dogs. Dig Dis Sci 2004; 49: 1418-1424.
19. Xu J and Chen JD. Peripheral mechanisms of sibutramine involving proximal gastric motility in dogs. Obesity (Silver Spring) 2006; 14: 1363-1370.
20. Liu S, Liu J and Chen JD. Neural mechanisms involved in the inhibition of intestinal motility induced by intestinal electrical stimulation in conscious dogs. Neurogastroenterol Motil 2006; 18: 62-68.
21. Qi H, Brining D and Chen JD. Rectal distension inhibits postprandial small intestinal motor activity partially via the adrenergic pathway in dogs. Scand J Gastroenterol 2007; 42: 807-813.
22. Iwa M, Strickland C, Nakade Y, Pappas TN and Takahashi T. Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs. Dig Dis Sci 2005; 50: 1264-1270.
23. Lin X, Hayes J, Peters LJ and Chen JD. Ent-rainment of intestinal slow waves with electrical stimulation using intraluminal electrodes. Ann Biomed Eng 2000; 28: 582-587.
24. Glia A and Lindberg G. Antroduodenal manometry findings in patients with slow-transit constipation. Scand J Gastroenterol 1998; 33: 55-62.
25. Preston DM and Lennard-Jones JE. Severe chronic constipation of young women: ‘idiopathic slow transit constipation’. Gut 1986; 27: 41-48.
26. Lipecka J, Bali M, Thomas A, Fanen P, Edelman A and Fritsch J. Distribution of ClC-2 chloride channel in rat and human epithelial tissues. Am J Physiol Cell Physiol 2002; 282: C805-816.
27. Jentsch TJ, Stein V, Weinreich F and Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev 2002; 82: 503-568.
28. Sherry AM, Malinowska DH, Morris RE, Ciraolo GM and Cuppoletti J. Localization of ClC-2 Cl-channels in rabbit gastric mucosa. Am J Physiol Cell Physiol 2001; 280: C1599-1606.
29. Roman RM, Smith RL, Feranchak AP, Clayton GH, Doctor RB and Fitz JG. ClC-2 chloride channels contribute to HTC cell volume homeostasis. Am J Physiol Gastrointest Liver Physiol 2001; 280: G344-353.
30. Cuppoletti J, Tewari KP, Sherry AM, Kupert EY and Malinowska DH. ClC-2 Cl-channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole. Am J Physiol Cell Physiol 2001; 281: C46-54.
31. Ueno R. Comment and reply on: CLC chloride channels and transporters: from genes to protein structure, pathology and physiology. Crit Rev Biochem Mol Biol 2009; 44: 243-244.
32. Lacy BE and Levy LC. Lubiprostone: a chloride channel activator. J Clin Gastroenterol 2007; 41: 345-351.
33. Grider JR and Jin JG. Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation. J Neurosci 1994; 14: 2854-2860.
34. Ambizas EM and Ginzburg R. Lubiprostone: a chloride channel activator for treatment of chronic constipation. Ann Pharmacother 2007; 41: 957-964.
35. Abo M, Kono T, Wang Z and Chen JD. Imp-airment of gastric and jejunal myoelectrical activity during rectal distension in dogs. Dig Dis Sci 2000; 45: 1731-1736.
36. Tjen-A-Looi SC, Hsiao AF, Longhurst JC. Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol Heart Circ Physiol 2011; 300: H1003-12.
37. Sweetser S, Busciglio IA, Camilleri M, Bharucha AE, Szarka LA, Papathanasopoulos A, Burton DD, Eckert DJ and Zinsmeister AR. Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects. Am J Physiol Gastrointest Liver Physiol 2009; 296: G295-301.
38. Rawal N, Desbiens J and Darbari A. Colonic manometry results of oral lubiprostone. Gastroenterology 2010; 136: 5 Suppl 1: S229.
39. Bojo L and Cassuto J. Gastric reflex relaxation by colonic distension. J Auton Nerv Syst 1992; 38: 57-64.