Neuroendocrine merkel cell carcinoma is associated with mutations in key DNA repair, epigenetic and apoptosis pathways: A case-based study using targeted massively parallel sequencing

Neuroendocrinology

Volumn 101, Issue 2, 2015, Pages 112-119

  Graves, Christian A ^a,b   Jones, Ashley ^b,c   Reynolds, Justin ^b   Stuart, Jeremy ^d   Pirisi, Lucia ^a   Botrous, Peter ^b   Wells, James ^a,b  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b WJB Dorn VA Medical Center   (United States)

^c LAKE ERIE COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^d Selah Genomics   (United States)

Author keywords

Massively parallel sequencing; Merkel cell carcinoma; Merkel cell polyomavirus; Neuroendocrine neoplasm

Indexed keywords

ANTINEOPLASTIC AGENT; ARGININE; AURORA KINASE; AURORA KINASE BETA; CHROMOGRANIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1 A1; CYCLIC AMP; CYTOKERATIN 20; GLUTAMINE; PHOSPHODIESTERASE 4 INTERACTING PROTEIN; PHOSPHODIESTERASE 4D; PHOSPHODIESTERASE IV; PROTEIN; SYNAPTOPHYSIN; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ACTINIC KERATOSIS; ADULT; AGED; ANEUPLOIDY; APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CARCINOGENESIS; CAUCASIAN; CELL CYCLE PROGRESSION; CENTROMERE; CLINICAL ARTICLE; DNA DAMAGE; DNA EXTRACTION; DNA REPAIR; ENZYME ACTIVITY; EPIGENETICS; EXON; FOLLOW UP; FRAMESHIFT MUTATION; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GERMLINE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INDEL MUTATION; MALE; MEDICAL RECORD REVIEW; MELANOMA; MERKEL CELL TUMOR; MIDDLE AGED; MISSENSE MUTATION; MULTIMODALITY CANCER THERAPY; MULTIPLEX POLYMERASE CHAIN REACTION; NEUROENDOCRINE MERKEL CELL CARCINOMA; NEUROENDOCRINE TUMOR; NEXT GENERATION SEQUENCING; NONSENSE MUTATION; NUCLEAR LOCALIZATION SIGNAL; PENETRANCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEMICONDUCTOR; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SQUAMOUS CELL CARCINOMA; TUMOR BIOPSY; ULTRAVIOLET IRRADIATION; VERY ELDERLY; XERODERMA PIGMENTOSUM; CARCINOMA; CASE CONTROL STUDY; GENETIC EPIGENESIS; GENETICS; HIGH THROUGHPUT SEQUENCING; MUTATION; PATHOLOGY; SKIN TUMOR;

AGED, 80 AND OVER; APOPTOSIS; CARCINOMA, MERKEL CELL; CARCINOMA, NEUROENDOCRINE; CASE-CONTROL STUDIES; DNA REPAIR; EPIGENESIS, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MIDDLE AGED; MUTATION; RETROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 84929955648     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000370310     Document Type: Article

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