Investigation the mechanism of the apoptosis induced by lactacystin in gastric cancer cells

Tumor Biology

Volumn 36, Issue 5, 2015, Pages 3465-3470

  Li, Yinghua ^a   Gao, Haifeng ^b   Wang, Yan ^a   Dai, Chaoyang ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Dalian Central Hospital   (China)

Author keywords

Caspase 3; Gastric cancer; Lactacystin; NF B; Nuclear factor kappa B

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTACYSTIN; TRANSCRIPTION FACTOR RELA; ACETYLCYSTEINE; DNA;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; DRUG EFFECTS; METABOLISM; PATHOLOGY; STOMACH NEOPLASMS; TUMOR CELL LINE;

ACETYLCYSTEINE; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; HUMANS; NF-KAPPA B; STOMACH NEOPLASMS;

EID: 84929948274     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2982-x     Document Type: Article

References (24)

1. Liu W, Yang Q, Liu B, Zhu Z. Serum proteomics for gastric cancer. Clin Chim Acta. 2014;431:179–84.
2. Fan XM, Wong BCY, Wang WP, Zhou XM, Cho CH, Yuen ST, et al. Inhibition of proteasome function induced apoptosis in gastric cancer. Int J Cancer. 2001;93:481–8.
3. Cohen G. Caspases: the executioners of apoptosis. Biochem J. 1997;326:1–16.
4. Milacic V, Banerjee S, Landis-Piwowar KR, Sarkar FH, Majumdar AP, Dou QP. Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res. 2008;68:7283–92.
5. Cusimano A, Azzolina A, Iovanna JL, Bachvarov D, McCubrey JA, D’Alessandro N, et al. Novel combination of celecoxib and proteasome inhibitor mg132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells. Cell Cycle. 2010;9:1399–410.
6. Rastogi N, Mishra DP. Therapeutic targeting of cancer cell cycle using proteasome inhibitors. Cell Div. 2012;26:7–26.
7. Slater E, Waldmann J, López C, Matthäi E, Fendrich V, Bartsch D. Pancreatic neuroendocrine tumors are characterized by loss of noxa expression that can be recovered by the proteasome inhibitor bortezomib. J Cancer Ther. 2013;4:28.
8. Budunova I. Differential targeting of androgen and glucocorticoid receptors induces er stress and apoptosis in prostate cancer cells. Cell Cycle. 2012;11:395–406.
9. Chen J, Giridhar KV, Zhang L, Xu S, Wang QJ. A protein kinase c/protein kinase d pathway protects lncap prostate cancer cells from phorbol ester-induced apoptosis by promoting erk1/2 and nf-κb activities. Carcinogenesis. 2011;32:1198–206.
10. Gasparian AV, Guryanova OA, Chebotaev DV, Shishkin AA, Yemelyanov AY, Budunova IV. Targeting transcription factor nfκb: comparative analysis of proteasome and ikk inhibitors. Cell Cycle. 2009;8:1559–66.
11. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. The ubiquitinproteasome pathway is required for processing the nf-κb1 precursor protein and the activation of nf-κb. Cell. 78:773–85.
12. Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 1997;387:296–9.
13. Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting nf-κb activation by small molecules as a therapeutic strategy. Biochim Biophys Acta (BBA) - Gene Regul Mech. 2010;1799:775–87.
14. Leotoing L, Chereau F, Baron S, Hube F, Valencia H, Bordereaux D, et al. A20-binding inhibitor of nuclear factor-kappab (nf-kappab)-2 (abin-2) is an activator of inhibitor of nf-kappab (ikappab) kinase alpha (ikkalpha)-mediated nf-kappab transcriptional activity. J Biol Chem. 2011;286:32277–88.
15. Cho W-R, Yoon H. Apple extracts attenuate tumor necrosis factor-α-induced nuclear factor-κb activation by inhibiting iκb kinase and proteasome in a549 human non-small lung carcinoma cells. Food Sci Biotechnol. 2012;21:1203–8.
16. White E. Life, death, and the pursuit of apoptosis. Genes Dev. 1996;10:1–15.
17. Singh S, Khar A. Activation of nfκb and ub-proteasome pathway during apoptosis induced by a serum factor is mediated through the upregulation of the 26 s proteasome subunits. Apoptosis. 2006;11:845–59.
18. Ahn J, Lee H, Kim S, Park J, Ha T. The anti-obesity effect of quercetin is mediated by the ampk and mapk signaling pathways. Biochem Biophys Res Commun. 2008;373:545–9.
19. Calvaruso G, Giuliano M, Portanova P, De Blasio A, Vento R, Tesoriere G. Bortezomib induces in hepg2 cells iκbα degradation mediated by caspase-8. Mol Cell Biochem. 2006;287:13–9.
20. Xia L, Zhang D, Du R, Pan Y, Zhao L, Sun S, et al. Mir‐15b and mir‐16 modulate multidrug resistance by targeting bcl2 in human gastric cancer cells. Int J Cancer. 2008;123:372–9.
21. Li Z, Zhan W, Wang Z, Zhu B, He Y, Peng J, et al. Inhibition of prl-3 gene expression in gastric cancer cell line sgc7901 via microrna suppressed reduces peritoneal metastasis. Biochem Biophys Res Commun. 2006;348:229–37.
22. Liang J, Pan Y, Zhang D, Guo C, Shi Y, Wang J, et al. Cellular prion protein promotes proliferation and g1/s transition of human gastric cancer cells sgc7901 and ags. FASEB J. 2007;21:2247–56.
23. Sun L, Wang X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer sgc-7901 cells. World J Gastroenterol. 2003;9:1930–4.
24. Porter AG, Jänicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999;6.