Imaging and analysis of microcalcifications and lipid/necrotic core calcification in fibrous cap atheroma

International Journal of Cardiovascular Imaging

Volumn 31, Issue 5, 2015, Pages 1079-1087

  Maldonado, Natalia ^a   Kelly Arnold, Adreanne ^a   Laudier, Damien ^a   Weinbaum, Sheldon ^a,b   Cardoso, Luis ^a,b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Fibrous cap rupture; Microcalcifications; Microcomputed tomography; Vulnerable plaque

Indexed keywords

ARTICLE; ATHEROMA; CORONARY ARTERY CALCIFICATION; FIBROATHEROMA; HISTOLOGY; HUMAN; HUMAN TISSUE; MICRO-COMPUTED TOMOGRAPHY; SOFT TISSUE; THICKNESS; THREE DIMENSIONAL IMAGING; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL CALCIFICATION; CHEMISTRY; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; DIAGNOSTIC IMAGING; FIBROSIS; METABOLISM; NECROSIS; PREDICTIVE VALUE; PROCEDURES; REPRODUCIBILITY; RUPTURE;

LIPID;

CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY VESSELS; FIBROSIS; HUMANS; LIPIDS; NECROSIS; PLAQUE, ATHEROSCLEROTIC; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RUPTURE, SPONTANEOUS; VASCULAR CALCIFICATION; X-RAY MICROTOMOGRAPHY;

EID: 84929946898     PISSN: 15695794     EISSN: 15730743     Source Type: Journal    
DOI: 10.1007/s10554-015-0650-x     Document Type: Article

References (23)

1. Burke AP, Farb A, Malcom GT, Liang Y, Smialek JE, Virmani R (1999) Plaque rupture and sudden death related to exertion in men with coronary artery disease. JAMA 281(10):921–926
2. Virmani R, Burke AP, Kolodgie FD, Farb A (2003) Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque. J Interv Cardiol 16(3):267–272
3. Burke AP, Farb A, Malcom GT, Liang YH, Smialek J, Virmani R (1997) Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med 336(18):1276–1282
4. Virmani R, Narula J, Leon M, Willerson JTE (2007) The vulnerable atherosclerotic plaque: strategies for diagnosis and management. Blackwell, Malden
5. Vliegenthart R, Oudkerk M, Hofman A et al (2005) Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation 112:572–577
6. Huang H, Virmani R, Younis H, Burke AP, Kamm RD, Lee RT (2001) The impact of calcification on the biomechanical stability of atherosclerotic plaques. Circulation 103(8):1051–1056
7. Vengrenyuk Y, Carlier S, Xanthos S, Cardoso L, Ganatos P, Virmani R et al (2006) A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci USA 103(40):14678–14683
8. Maldonado N, Kelly-Arnold A, Vengrenyuk Y, Laudier D, Fallon JT, Virmani R et al (2012) A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. Am J Physiol Heart Circ Physiol 303(5):H619–H628
9. Maldonado N, Kelly-Arnold A, Cardoso L, Weinbaum S (2013) The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding. J Biomech 46(2):396–401
10. Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, Weinbaum S (2013) A revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proc Natl Acad Sci USA 110(26):10741–10746
11. Vengrenyuk Y, Cardoso L, Weinbaum S (2008) Micro-CT based analysis of a new paradigm for vulnerable plaque rupture: cellular microcalcifications in fibrous caps. Mol Cell Biomech 5(1):37
12. Vengrenyuk Y, Kaplan TJ, Cardoso L, Randolph GJ, Weinbaum S (2010) Computational stress analysis of atherosclerotic plaques in ApoE knockout mice. Ann Biomed Eng 38(3):738–747
13. Rambhia SH, Liang X, Xenos M, Alemu Y, Maldonado N, Kelly A et al (2012) Microcalcifications increase coronary vulnerable plaque rupture potential: a patient-based micro-CT fluid-structure interaction study. Ann Biomed Eng 40(7):1443–1454
14. Cardoso L, Kelly-Arnold A, Maldonado N, Laudier D, Weinbaum S (2014) Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models. J Biomech 47(4):870–877
15. Cardoso L, Weinbaum S (2014) Changing views of the biomechanics of vulnerable plaque rupture: a review. Ann Biomed Eng 42(2):415–431
16. Palacio-Mancheno PE, Larriera AI, Doty SB, Cardoso L, Fritton SP (2014) 3D assessment of cortical bone porosity and tissue mineral density using high-resolution micro-CT: effects of resolution and threshold method. J Bone Miner Res 29(1):142–150
17. Hutcheson J, Maldonado N, Aikawa E (2014) Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability. Curr Opin Lipidol 25(5):327–332
18. Bobryshev YV, Killingsworth MC, Lord RS, Grabs AJ (2008) Matrix vesicles in the fibrous cap of atherosclerotic plaque: possible contribution to plaque rupture. J Cell Mol Med 12(5B):2073–2082
19. Roijers RB, Debernardi N, Cleutjens JP, Schurgers LJ, Mutsaers PH, van der Vusse GJ (2011) Microcalcifications in early intimal lesions of atherosclerotic human coronary arteries. Am J Pathol 178(6):2879–2887
20. New SEP, Aikawa E (2011) Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification. Circ Res 108(11):1381–1391
21. Ohayon J, Finet G, Gharib AM, Herzka DA, Tracqui P, Heroux J et al (2008) Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture. Am J Physiol Heart Circ Physiol 295(2):H717–H727
22. Akyildiz AC, Speelman L, van Brummelen H, Gutierrez MA, Virmani R, van der Lugt A et al (2011) Effects of intima stiffness and plaque morphology on peak cap stress. Biomed Eng Online 10:25
23. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20(5):1262–1275