Fenofibrate induces G0/G1 phase arrest by modulating the PPARα/FoxO1/p27kip pathway in human glioblastoma cells

Tumor Biology

Volumn 36, Issue 5, 2015, Pages 3823-3829

  Han, Dong feng ^a   Zhang, Jun xia ^a   Wei, Wen jin ^a   Tao, Tao ^a   Hu, Qi ^a   Wang, Ying yi ^a   Wang, Xie feng ^a   Liu, Ning ^a   You, Yong ping ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Antiproliferation; Fenofibrate; Fork head box O1 (FoxO1); Peroxisome proliferator activated receptor alpha (PPAR )

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; FENOFIBRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TUMOR PROTEIN;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; GENE EXPRESSION; GENE ONTOLOGY; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; BIOSYNTHESIS; CELL CYCLE CHECKPOINT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN GENOME; PATHOLOGY; TUMOR CELL LINE;

CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FENOFIBRATE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; GLIOBLASTOMA; HUMANS; NEOPLASM PROTEINS; PPAR ALPHA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84929946772     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-3024-4     Document Type: Article

References (30)

1. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New Engl J Med. 2005;352:987–96.
2. Drappatz J, Norden AD. Wen PY Therapeutic strategies for inhibiting invasion in glioblastoma. Expert Rev Neurother. 2009;9:519–34.
3. Blane GF. Review of European clinical experience with fenofibrate. Cardiology. 1989;76 Suppl 1:1–10. discussion 10–13.
4. Jiao H. Cytotoxic effect of peroxisome proliferator fenofibrate on human HepG2 hepatoma cell line and relevant mechanisms. Toxicol Appl Pharmacol. 2002;185:172–9.
5. Saidi SA, Holland CM, Charnock-Jones DS, et al. In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer. Mol Cancer. 2006;5:13.
6. Panigrahy D, Kaipainen A, Huang S, et al. PPARα agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition. Proc Natl Acad Sci U S A. 2008;105:985–90.
7. Drukala J, Urbanska K, Wilk A, et al. ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of glioma cell motility in vitro. Mol Cancer. 2010;9:159.
8. Grabacka M, Placha W, Plonka PM, et al. Inhibition of melanoma metastases by fenofibrate. Arch Dermatol Res. 2004;296:54–8.
9. Grabacka M. Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt. Clin Cancer Res. 2006;12:3028–36.
10. Urbanska K, Pannizzo P, Grabacka M, et al. Activation of PPARα inhibits IGF-I‐mediated growth and survival responses in medulloblastoma cell lines. Int J Cancer. 2008;123:1015–24.
11. Guttilla IK. White BA Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009;284:23204–16.
12. Goto T, Takano M, Albergaria A, et al. Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells. Oncogene. 2008;27:9–19.
13. Dong XY, Chen CS, Sun XD, et al. FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer. Cancer Res. 2006;66:6998–7006.
14. Kojima T, Shimazui T, Horie R, et al. FOXO1 and TCF7L2 genes involved in metastasis and poor prognosis in clear cell renal cell carcinoma. Gene Chromosome Canc. 2010;49:379–89.
15. Machida S, Spangenburg EE. Booth FW Forkhead transcription factor FOXO1 transduces insulin-like growth factor’s signal to p27Kip1 in primary skeletal muscle satellite cells. J Cell Physiol. 2003;196:523–31.
16. Aoki M, Jiang H. Vogt PK Proteasomal degradation of the FoXO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins. Proc Natl Acad Sci U S A. 2004;101:13613–7.
17. Lau CJ, Koty Z. Nalbantoglu J Differential response of glioma cells to FOXO1-directed therapy. Cancer Res. 2009;69:5433–40.
18. Lupi M, Cappella P, Matera G, et al. Interpreting cell cycle effects of drugs: the case of melphalan. Cancer Chemoth Pharm. 2006;57:443–57.
19. Gorczyca W, Gong J, Ardelt B, et al. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 1993;53:3186–92.
20. von Daniken A, Lutz WK. Schlatter C Lack of covalent binding to rat liver DNA of the hypolipidemic drugs clofibrate and fenofibrate. Toxicol Lett. 1981;7:305–10.
21. Zeng R, Xiong Y, Zhu FM, et al. Fenofibrate attenuated glucose-induced mesangial cells proliferation and extracellular matrix synthesis via PI3K/AKT and ERK1/2. Plos One. 2013;8:e76836.
22. Li T, Zhang Q, Zhang J, et al. Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-kappaB pathway. BMC Cancer. 2014;14:96.
23. Wilk A, Wyczechowska D, Zapata A, et al. Molecular mechanisms of fenofibrate-induced metabolic catastrophe and glioblastoma cell death. Mol Cell Biol. 2014;57:744.
24. Yamasaki F, Hama S, Yoshioka H, et al. Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/m and at G1 in U251MG human glioma cell line. Cancer Chemother Pharmacol. 2003;51:271–83.
25. Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009;9:550–62.
26. Huang HJ. Tindall DJ Dynamic FoXO transcription factors. J Cell Sci. 2007;120:2479–87.
27. Chen W-L, Chen Y-L, Chiang Y-M, et al. Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoXO1/ATGL pathway. Biochem Pharmacol. 2012;84:522–31.
28. Liang J, Zubovitz J, Petrocelli T, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med. 2002;8:1153–60.
29. Ciarallo S, Subramaniam V, Hung W, et al. Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol. 2002;22:2993–3002.
30. Schiappacassi M, Lovat F, Canzonieri V, et al. p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis. Mol Cancer Ther. 2008;7:1164–75.