Myofiber HLA-DR expression is a distinctive biomarker for antisynthetase-associated myopathy

Acta Neuropathologica Communications

Volumn 2, Issue 1, 2014, Pages

  Aouizerate, Jessie ^a,b   De Antonio, Marie ^a,c   Bassez, Guillaume ^a,b   Gherardi, Romain K ^a,b   Berenbaum, Francis ^d   Guillevin, Loïc ^e   Berezne, Alice ^e   Valeyre, Dominique ^f   Maisonobe, Thierry ^g   Dubourg, Odile ^g   Cosnes, Anne ^a   Benveniste, Olivier ^g   Authier, François Jérôme ^a,b  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d HÔPITAL SAINT ANTOINE   (France)

^e Internal Medicine ^*  (France)

^f AVICENNE HOSPITAL   (France)

^g PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Anti synthetase; Complement; Dermatomyositis; HLA DR; Inflammatory myopathy

Indexed keywords

BIOLOGICAL MARKER; HLA ANTIGEN; HLA DR ANTIGEN;

ADOLESCENT; ADULT; AGED; DERMATOMYOSITIS; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; MYOSITIS; PATHOLOGY; SKELETAL MUSCLE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; DERMATOMYOSITIS; FEMALE; HLA ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MYOSITIS; YOUNG ADULT;

EID: 84929938733     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/s40478-014-0154-2     Document Type: Article

References (36)

1. De Bleecker JL, Lundberg IE, de Visser M: 193rd ENMC International workshop Pathology diagnosis of idiopathic inflammatory myopathies 30 November - 2 December 2012, Naarden, The Netherlands. Neuromuscul Disord 2013, 23(11):945-951. doi:10.1016/j.nmd.2013.07.007
2. Hoogendijk JE, Amato AA, Lecky BR, Choy EH, Lundberg IE, Rose MR, Vencovsky J, de Visser M, Hughes RA: 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. Neuromuscul Disord 2004, 14(5):337-345. doi:10.1016/j.nmd.2004.02.006
3. Gitiaux C, Kostallari E, Lafuste P, Authier FJ, Christov C, Gherardi RK: Whole microvascular unit deletions in dermatomyositis. Ann Rheum Dis 2013, 72(3):445-452. doi:10.1136/annrheumdis-2012-201822 10.1136/annrheumdis-2012-201822
4. Ranque B, Bérezné A, Le-Guern V, Pagnoux C, Allanore Y, Launay D, Hachulla E, Authier FJ, Gherardi R, Kahan A, Cabane J, Guillevin L, Mouthon L: Myopathies related to systemic sclerosis: a case-control study of associated clinical and immunological features. Scand J Rheumatol 2010, 39(6):498-505. doi:10.3109/03009741003774626
5. Mahler M, Miller FW, Fritzler MJ: Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review. Autoimmun Rev 2014, 13(4-5):367-371. doi:10.1016/j.autrev.2014.01.022
6. Marie I, Josse S, Decaux O, Dominique S, Diot E, Landron C, Roblot P, Jouneau S, Hatron PY, Tiev KP, Vittecoq O, Noel D, Mouthon L, Menard JF, Jouen F: Comparison of long-term outcome between anti-Jo1-and anti-PL7/PL12 positive patients with antisynthetase syndrome. Autoimmun Rev 2012, 11(10):739-745. doi:10.1016/j.autrev.2012.01.006
7. Hervier B, Devilliers H, Stanciu R, Meyer A, Uzunhan Y, Masseau A, Dubucquoi S, Hatron PY, Musset L, Wallaert B, Nunes H, Maisonobe T, Olsson NO, Adoue D, Arlet P, Sibilia J, Guiguet M, Lauque D, Amoura Z, Hachulla E, Hamidou M, Benveniste O: Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity. Autoimmun Rev 2012, 12(2):210-217. doi:10.1016/j.autrev.2012.06.006
8. Mammen AL: Dermatomyositis and polymyositis: clinical presentation, autoantibodies, and pathogenesis. Ann N Y Acad Sci 2010, 1184: 134-153. doi:10.1111/j.1749-6632.2009.05119.x
9. Mammen AL: Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis. Nat Rev Neurol 2011, 7(6):343-354. doi:10.1038/nrneurol.2011.63
10. Pestronk A: Acquired immune and inflammatory myopathies: pathologic classification. Curr Opin Rheumatol 2011, 23(6):595-604. doi:10.1097/BOR.0b013e32834bab42
11. TargoffIN: Idiopathic inflammatory myopathy: autoantibody update. Curr Rheumatol Rep 2002, 4(5):434-441. 10.1007/s11926-002-0089-7
12. Mozaffar T, Pestronk A: Myopathy with anti-Jo-1 antibodies: pathology in perimysium and neighbouring muscle fibres. J Neurol Neurosurg Psychiatry 2000, 68(4):472-478. 10.1136/jnnp.68.4.472
13. Hamaguchi Y, Fujimoto M, Matsushita T, Kaji K, Komura K, Hasegawa M, Kodera M, Muroi E, Fujikawa K, Seishima M, Yamada H, Yamada R, Sato S, Takehara K, Kuwana M: Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome. PLoS One 2013, 8(4):e60442. doi:10.1371/journal.pone.0060442
14. Aouba A, Georgin-Lavialle S, Terrier B, Guillevin L, Authier FJ: Anti-PL7 antisynthetase syndrome under interferon therapy. Joint Bone Spine 2011, 78(1):94-97. doi:10.1016/j.jbspin.2010.07.012
15. Authier FJ, Chazaud B, Plonquet A, Eliezer-Vanerot MC, Poron F, Belec L, Barlovatz-Meimon G, Gherardi RK: Differential expression of the IL-1 system components during in vitro myogenesis: implication of IL-1beta in induction of myogenic cell apoptosis. Cell Death Differ 1999, 6(10):1012-1021. doi:10.1038/sj.cdd.4400576
16. Gherardi RK: Pathogenic aspects of dermatomyositis, polymyositis and overlap myositis. Presse Med 2011, 40(4 Pt 2):e209-218. doi:10.1016/j.lpm.2010.12.013
17. van der Pas J, Hengstman GJ, Ter Laak HJ, Borm GF, van Engelen BG: Diagnostic value of MHC class I staining in idiopathic inflammatory myopathies. J Neurol Neurosurg Psychiatry 2004, 75(1):136-139.
18. Englund P, Lindroos E, Nennesmo I, Klareskog L, Lundberg IE: Skeletal muscle fibers express major histocompatibility complex class II antigens independently of inflammatory infiltrates in inflammatory myopathies. Am J Pathol 2001, 159(4):1263-1273. doi:10.1016/S0002-9440(10)62513-8
19. Inukai A, Kuru S, Liang Y, Takano A, Kobayashi Y, Sakai M, Doyu M, Sobue G: Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis. Muscle Nerve 2000, 23(3):385-392. 10.1002/(SICI)1097-4598(200003)23:3<385::AID-MUS10>3.0.CO;2-T
20. Mantegazza R, Gebbia M, Mora M, Barresi R, Bernasconi P, Baggi F, Cornelio F: Major histocompatibility complex class II molecule expression on muscle cells is regulated by differentiation: implications for the immunopathogenesis of muscle autoimmune diseases. J Neuroimmunol 1996, 68(1-2):53-60. 10.1016/0165-5728(96)00068-9
21. McDouall RM, Dunn MJ, Dubowitz V: Expression of class I and class II MHC antigens in neuromuscular diseases. J Neurol Sci 1989, 89(2-3):213-226. 10.1016/0022-510X(89)90023-3
22. Confalonieri P, Oliva L, Andreetta F, Lorenzoni R, Dassi P, Mariani E, Morandi L, Mora M, Cornelio F, Mantegazza R: Muscle inflammation and MHC class I up-regulation in muscular dystrophy with lack of dysferlin: an immunopathological study. J Neuroimmunol 2003, 142(1-2):130-136. 10.1016/S0165-5728(03)00255-8
23. Michaelis D, Goebels N, Hohlfeld R: Constitutive and cytokine-induced expression of human leukocyte antigens and cell adhesion molecules by human myotubes. Am J Pathol 1993, 143(4):1142-1149.
24. Ivanidze J, Hoffmann R, Lochmuller H, Engel AG, Hohlfeld R, Dornmair K: Inclusion body myositis: laser microdissection reveals differential up-regulation of IFN-gamma signaling cascade in attacked versus nonattacked myofibers. Am J Pathol 2011, 179(3):1347-1359. doi:10.1016/j.ajpath.2011.05.055
25. Dorph C, Englund P, Nennesmo I, Lundberg IE: Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis. Ann Rheum Dis 2006, 65(12):1565-1571. doi:10.1136/ard.2005.051086
26. Londhe P, Davie JK: Gamma interferon modulates myogenesis through the major histocompatibility complex class II transactivator, CIITA. Mol Cell Biol 2011, 31(14):2854-2866. doi:10.1128/MCB.05397-11
27. Uro-Soste E, Fernandez C, Authier FJ, Bassez G, Butori C, Chapon F, Delisle MB, Dubourg O, Feasson L, Gherardi R, Lacroix C, Laquerriere A, Letournel F, Magy L, Maisonobe T, Marcorelles P, Maurage CA, Mezin P, Mussini JM, Penisson-Besnier I, Romero NB, Streichenberger N, Vallat JM, Viennet G, Vital A, Voit T, Boucharef W, Figarella-Branger D: Management of muscle and nerve biopsies: expert guidelines from two French professional societies, Societe francaise de myologie et de l'Association francaise contre les myopathies. Rev Neurol 2010, 166(5):477-485. 10.1016/j.neurol.2010.03.015
28. Authier M, Gagnon M, Lortie M: Handling techniques: the influence of weight and height for experts and novices. Int J Occup Saf Ergon 1995, 1(3):262-275.
29. Varsani H, Charman SC, Li CK, Marie SK, Amato AA, Banwell B, Bove KE, Corse AM, Emslie-Smith AM, Jacques TS, Lundberg IE, Minetti C, Nennesmo I, Rushing EJ, Sallum AM, Sewry C, Pilkington CA, Holton JL, Wedderburn LR, the UKJDRG (2013) Validation of a score tool for measurement of histological severity in juvenile dermatomyositis and association with clinical severity of disease. Ann Rheum Dis. doi:10.1136/annrheumdis-2013-203396
30. Toquet C, Hamidou MA, Renaudin K, Jarry A, Foulc P, Barbarot S, Laboisse C, Mussini JM: In situ immunophenotype of the inflammatory infiltrate in eosinophilic fasciitis. J Rheumatol 2003, 30(8):1811-1815.
31. Greenberg SA, Amato AA: Uncertainties in the pathogenesis of adult dermatomyositis. Curr Opin Neurol 2004, 17(3):359-364. 10.1097/00019052-200406000-00018
32. Han R: Muscle membrane repair and inflammatory attack in dysferlinopathy. Skeletal muscle 2011, 1(1):10. doi:10.1186/2044-5040-1-10
33. Lahat N, Bitterman H, Weiss-Cerem L, Rahat MA: Hypoxia increases membranal and secreted HLA-DR in endothelial cells, rendering them T-cell activators. Transpl Int 2011, 24(10):1018-1026. doi:10.1111/j.1432-2277.2011.01304.x
34. Neefjes J, Jongsma ML, Paul P, Bakke O: Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol 2011, 11(12):823-836. doi:10.1038/nri3084
35. Schoenborn JR, Wilson CB: Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol 2007, 96: 41-101. doi:10.1016/S0065-2776(07)96002-2
36. Reith W, LeibundGut-Landmann S, Waldburger JM: Regulation of MHC class II gene expression by the class II transactivator. Nat Rev Immunol 2005, 5(10):793-806. doi:10.1038/nri1708