Influence of ulinastatin on the proliferation of vascular endothelial cells and IL-6 and TNF-α release under heat stress

Medical Journal of Chinese People's Liberation Army

Volumn 40, Issue 5, 2015, Pages 362-365

  Pan, Zhi Guo ^a   Shao, Yu ^b   Geng, Yan ^a   Chen, Jing He ^c   Su, Lei ^a  

^a Department of Intensive Care Unit The Military Key Laboratory of Trauma Care in Hot Zone and Tissue Repair in PLA   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Cell proliferation; Endothelial cell; Heat stroke; Ulinastatin

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAT STRESS; HUMAN; HUMAN CELL; UMBILICAL VEIN ENDOTHELIAL CELL;

EID: 84929935052     PISSN: 05777402     EISSN: None     Source Type: Journal    
DOI: 10.11855/j.issn.0577-7402.2015.05.06     Document Type: Article

References (19)

1. Su L, Guo ZH, Qian HJ. Epidemiological study and key-point analysis of severe heatstroke patients[J]. Med J Chin PLA, 2006, 31(9): 909-911.
2. Glazer JL. Management of heatstroke and heat exhaustion[J]. Am Fam Physician, 2005, 71(11): 2133-2140.
3. Bouchama A, Knochel JP. Heat stroke [J]. N Engl J Med, 2002, 346(25): 1978-1988.
4. Hammami MM, Bouchama A, Al-Sedairy S, et al. Concentrations of soluble tumor necrosis factor and interleukin-6 receptors in heatstroke and heatstress[J]. Crit Care Med, 1997, 25(8): 1314-1319.
5. Roberts GT, Ghebeh H, Chishti MA, et al. Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model[J]. Arterioscler Thromb Vasc Biol, 2008, 28(6): 1130-1136.
6. Tong HS, Chen Y, Tang YQ, et al. Protection of ulinastatin on the endothelial cell injury of patients with severe heatshock[J]. Guangdong Med J, 2011 (12): 1574-1576.
7. Pan ZG, Geng Y, Zhang JM, et al. Effect of heat stress on the injury of vascular endothelial cells and release of IL-6 and TNF-α in vitro[J]. Shandong Med J, 2012, 52(3): 32-34.
8. Pan ZG. Mechanism of rhabdomyolysis in patients with severe hearshock[D]. 2012
9. Leon LR, Blaha MD, Dubose DA. Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery[J]. J Appl Physiol, 2006, 100(4): 1400-1409.
10. Tong HS, Duan PK, Zhang XQ, et al. Inflammatory activity of endothelial cells activated by intestinal lymph in severe heat stroke[J]. Med J Chin PLA, 2014, 39(10): 791-794.
11. Chen CM, Hou CC, Cheng KC, et al. Activated protein C therapy in a rat heat stroke model[J]. Crit Care Med, 2006, 34(7): 1960-1966.
12. Bouchama A, Roberts G, AI Mohanna F, et al. Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke[J]. J Appl Physiol, 2005, 98(2): 697-705.
13. Keuren JF, Baruch D, Legendre P, et al. von Willebrand factor C1C2 domain is involved in platelet adhesion to polymerized fibrin at high shear rate[J]. Blood, 2004, 103(5): 1741-1746.
14. Masuda T, Sato K, Noda C, et al. Protective effect of urinary tryps in inhibi tor on myoc a rdi a l mi tochondr i a dur ing hemorrhagic shock and reperfusion[J]. Crit Care Med, 2003, 31(7): 1987-1992.
15. Li N, You SY, Wang CL, et al. The effects of ulinastatin on SP-A in lung injury induced by severe acute pancreatitis in rats[J]. Tianjin Med J, 2013, 41(3): 241-243+290.
16. Liu YF, Wang ZG, Tang HW, et al. Protective effect of ulinastatin on inhalation lung injury caused by black gunpowder smoke in rats and its inhibitory effect on the mRNA expression of IL-1β and TNF-α[J]. Med J Chin PLA, 2014, 39(3): 235-239.
17. Wang H, Liu GJ, Hu M. Protective effect of ulinastatin combined with xuebijing on multiple organ function in Patients with sepsis[J]. Chin J Pract Intern Med, 2014, 34(S1): 113-116.
18. Wu CY, Xiao F, Yu L, et al. Tolerance test of ulinastati[J]. Chin J Clin Pharmacol Ther, 2007 (1): 103-106.
19. Jing BW. Progress of the clinical application of ulinastati on the critical illness[J]. Chin Crit Care Med, 2006, 18(2): 117-120.