Protective effect of ulinastatin on inhalation lung injury caused by black gunpowder smoke in rats and its inhibitory effect on the mRNA expression of IL-1β and TNF-α

Medical Journal of Chinese People's Liberation Army

Volumn 39, Issue 3, 2014, Pages 235-239

  Liu, Yi Fan ^a   Wang, Zheng Guan ^a   Tang, Hong Wei ^a   Wu, Xiao Li ^b   Xie, Yin Jing ^b   Zhang, Hong Rui ^b   Li, Deng Qing ^c   Wang, Cheng Bin ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c The First People s Hospital of Changde City)   (China)

Author keywords

Black powder; Interleukin 1 ; Smoke inhalation injury; Tumor necrosis factor ; Ulinastatin

Indexed keywords

GUNPOWDER; INTERLEUKIN 1BETA; MALONALDEHYDE; MYELOPEROXIDASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTERIAL GAS; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; EXUDATE; HISTOLOGY; INFLAMMATORY INFILTRATE; LEUKOCYTE COUNT; LOW DRUG DOSE; LUNG INJURY; LUNG LAVAGE; LUNG WET TO DRY WEIGHT RATIO; MALE; MRNA EXPRESSION ASSAY; NONHUMAN; RAT; RESPIRATORY TRACT PARAMETERS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKE;

EID: 84921966944     PISSN: 05777402     EISSN: None     Source Type: Journal    
DOI: 10.11855/j.issn.0577-7402.2014.03.14     Document Type: Article

References (14)

1. Liu YF, Tang HW, Wu XL, et al. Establishment and evaluation of a rat model of inhalation lung injury caused by black gunpowder smog[J]. Med J Chin PLA, 2013, 38(8): 60-65.
2. Zhou Y, Lan XM, Wang CB. Study on the secretion of IL-8 and IL-6 by bronchial epithelial cells (BEAS-2B) injured by black powder smoke and the curative effect of puerarin[J]. Med J Chin PLA, 2012, 37(3): 260-262.
3. Zhou Y, Wang CB, Lan XM. Puerarin inhibits gene expression of IL-8 and IL-6 in BEAS-2B cells injured by black powder smoke [J]. Pharm J Chin PLA, 2012, 28(1): 10-14.
4. Sato Y, Ishikawa S, Otaki A, et al. Induction of acute-phase reactive substances during open-heard surgery and efficacy of ulinastatin in inhibiting cytokines and postoperative organ injury[J]. Jpn J Thorac Cardiovasc Surg, 2000, 48(7): 428-434.
5. Li N, You SY, Wang CL, et al. The effects of ulinastatin on sp-a in lung injury induced by severe acute pancreatitis in rats [J]. Tianjin Med J, 2013, 41(3): 241-243
6. Wang XH, Hu JH, Shen YZ. Protective effects of Xingnaojing combined with ulinastatin on brain injury in severe acute pancreatitis of rats [J]. Tianjin Med J, 2013, 41(4):349-352
7. Inoue K, Takano H, Shimada A, et al. Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide[J]. Mol Pharmacol, 2005, 67(3): 673-680.
8. Gao C, Liu Y, Ma L, et al. Protective effects of ulinastatin on pulmonary damage in rats following scald injury[J]. Burns, 2012, 38(7): 1027-1034.
9. Xu M, Wen XH, Chen SP, et al. Addition of ulinastatin to preservation solution promotes protection against ischemia-reperfusion injury in rabbit lung[J]. Chin Med J (Engl), 2011, 124(14): 2179-2183.
10. Yao L, Kan EM, Lu J, et al. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia[J]. J Neuroinflammation, 2013, 10: 23.
11. Qiu X, Wang J, Li H, et al. The therapeutic efficacy of ulinastatin for rats with smoking inhalation injury[J]. Intimmunopharmacol, 2012, 14(3): 289-295.
12. Hu Q, Chai JK, Yang HM. Research progression of lung injury after burn-blast combined injury[J]. Med J Chin PLA, 2013, 38(5): 428-432
13. Ito K, Mizutani A, Kira S, et al. Effect of ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes [J]. Injury, 2005, 36(3): 387-394.
14. Xu P, Fang Y, Yu WR, et al. Protective effects of ulinastatin on lung injury from severe burns in rats [J]. J Shanghai Jiaotong Univ (Med Sci), 2009, 29(1): 51-53