Does good medication adherence really save payers money?

Medical Care

Volumn 53, Issue 6, 2015, Pages 517-523

  Stuart, Bruce C ^a   Dai, Mingliang ^b   Xu, Jing ^b   E Loh, Feng Hua ^a   S Dougherty, Julia ^c  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c Pharmaceutical Research and Manufacturers of America   (United States)

Author keywords

costs offsets; healthy adherer bias; medication adherence

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ORAL ANTIDIABETIC AGENT;

AGED; ARTICLE; CHRONIC DISEASE; CORRELATION ANALYSIS; COST CONTROL; DIABETES MELLITUS; DRUG COST; FEMALE; HEALTH CARE COST; HEALTHY ADHERER BIAS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICARE; MEDICATION COMPLIANCE; PRIORITY JOURNAL; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL BIAS; VERY ELDERLY; COST; DEMOGRAPHY; DRUG UTILIZATION; ECONOMICS; GOVERNMENT; INSURANCE; METHODOLOGY; MIDDLE AGED; SOCIOECONOMICS; STATISTICS AND NUMERICAL DATA; UNITED STATES;

AGED; AGED, 80 AND OVER; CENTERS FOR MEDICARE AND MEDICAID SERVICES (U.S.); COSTS AND COST ANALYSIS; DIABETES MELLITUS; DRUG UTILIZATION; FEMALE; HUMANS; INSURANCE CLAIM REVIEW; MALE; MEDICARE PART D; MEDICATION ADHERENCE; MIDDLE AGED; RESEARCH DESIGN; RESIDENCE CHARACTERISTICS; SOCIOECONOMIC FACTORS; UNITED STATES;

EID: 84929927168     PISSN: 00257079     EISSN: 15371948     Source Type: Journal    
DOI: 10.1097/MLR.0000000000000360     Document Type: Article

References (26)

1. Sokol MC, McGuigan KA, Verbrugge RR, et al. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care. 2005;43:521-530.
2. Salas M, Hughes D, Zuluaga A, et al. Costs of medication nonadherence in patients with diabetes mellitus: a systematic review and critical analysis of the literature. Value Health. 2009;19:915-922.
3. Lee WC, Balu S, Cobden D, et al. Prevalence and economic consequences of medication adherence in diabetes: a systematic literature review. Manag Care Interface. 2006;19:31-41.
4. Ettinger AB, Manjunath R, Candrilli SD, et al. Prevalence and cost of nonadherence to antiepileptic drugs in elderly patients with epilepsy. Epilepsy Behav. 2009;14:324-329.
5. Kane S, Shaya F. Medication nonadherence is associated with increased health care costs. Dig Dis Sci. 2008;53:1020-1024.
6. US Congressional Budget Office. Offsetting Effects of Prescription Drug Use on Medicare's Spending for Medical Services. Washington, DC: Government Printing Office; 2012.
7. Roebuck MC, Liberman JN, Gemmill-Toyama M, et al. Medication adherence leads to lower healthcare use and costs despite increased drug spending. Health Aff (Millwood). 2011;30:91-99.
8. Britton A, Choudhry NK, Matlin OS, et al. The impact of medication adherence on coronary artery disease costs and outcomes: a systematic review. Am J Med. 2013;126:357. e7-357. e27.
9. Granger BB, Swedberg K, Ekman I, et al. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double-blind, randomised, controlled clinical trial. Lancet. 2005;366:2005-2011.
10. Simpson SH, Eurich DT, Majumdar SR, et al. A meta-analysis of the association between adherence to drug therapy and mortality. Br Med J. 2006;333:15.
11. Curtis JR, Delzell E, Chen L, et al. The relationship between bisphosphonate adherence and fracture: is it the behavior or the medication Results from the placebo arm of the Fracture Intervention trial. J Bone Miner Res. 2011;26:683-688.
12. Brookhart MA, Patrick AR, Dormuth C, et al. Adherence to lipidlowering therapy and the use of preventive health services: an investigation of the healthy user effect. Am J Epidemiol. 2007;1666: 348-354.
13. Dormuth CR, Patrick AR, Shrank WH, et al. Statin adherence and risk of accidents: a cautionary tale. Circulation. 2009;119:2051-2057.
14. Shrank WH, Patrick AR, Brookhart MA. Health user and related biases in observational studies of preventive interventions: a primer for physicians. J Gen Intern Med. 2011;26:546-550.
15. Silverman SL, Gold DT. Health users, health adherers, and healthy behaviors? J Bone Miner Res. 2011;26:681-682.
16. Patrick AR, Shrank WH, Glynn RJ, et al. The association between statin use and outcomes potentially attributable to an unhealthy lifestyle in older adults. Value Health. 2011;14:513-520.
17. Encinosa WE, Bernard D, Dor AQ. Does prescription drug adherence reduce hospitalization and costs The case of diabetes. Adv Health Econ Health Serv Res. 2010;22:151-173.
18. Pelletier EM, Pawaskar M, Smith PJ, et al. Economic outcomes of exenatide vs. liraglutide in type 2 diabetes patients in the United States: results from a retrospective claims database analysis. J Med Econ. 2012;15:1039-1050.
19. Gibson TB, Song X, Alemayehu B, et al. Cost sharing, adherence, and health outcomes in patients with diabetes. Am J Manag Care. 2010;16:589-600.
20. Pawaskar MD, Camacho FT, Anderson RT, et al. Health care costs and medication adherence associated with initiation of insulin pen therapy in Medicaid-enrolled patients with type 2 diabetes: a retrospective database analysis. Clin Ther. 2007;29(pt 1):1294-1305.
21. Stuart B, Loh FL, Roberto P, et al. Increasing Medicare Part D enrollment in medication therapy management could improve health and lower costs. Health Aff (Millwood). 2013;32:1212-1220.
22. Jimenez-Garcia R, Esteban-Hernandez J, Hernandez-Barrera V, et al. Clustering of unhealthy lifestyle behaviors is associated with nonadherence to clinical preventive recommendations among adults with diabetes. J Diabetes Complications. 2011;25:107-113.
23. World Health Organization. Adherence to Long-Term Therapies: Evidence for Action. Geneva: WHO; 2003.
24. Stuart B, Davidoff A, Lopert R, et al. Does medication adherence lower Medicare spending among beneficiaries with diabetes Health Serv Res. 2011;46:1180-1199.
25. Stuart B, Simoni-Wastila L, Zhao L, et al. Increased persistency in medication use by US Medicare beneficiaries with diabetes is associated with lower hospitalization rates and cost savings. Diabetes Care. 2009;32:647-649.
26. Zhao Y, Zabriski S, Bertram C. Association between statin adherence level, health care costs, and utilization. J Man Care Pharm. 2014;20: 703-713.