Meeting current musculoskeletal health demand through deeper insights into tissue homeostasis and regeneration

Expert Opinion on Biological Therapy

Volumn 15, Issue 6, 2015, Pages 767-771

  Andia, Isabel ^a   Maffulli, Nicola ^b  

^a BIOCRUCES BIZKAIA HEALTH RESEARCH INSTITUTE   (Spain)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cell therapies; Osteoarthritis; Platelet rich plasma; Tendinopathy; Tissue healing

Indexed keywords

ANGIOGENESIS; CELL COMPARTMENTALIZATION; CELL THERAPY; CHRONIC DISEASE; EXTRACELLULAR MATRIX; HOMEOSTASIS; HUMAN; INFLAMMATION; MUSCULOSKELETAL DISEASE; OSTEOARTHRITIS; PARACRINE SIGNALING; REVIEW; STEM CELL; TENDINITIS; THROMBOCYTE RICH PLASMA; TISSUE REGENERATION; TISSUE REPAIR; MUSCULOSKELETAL DISEASES; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION; TENDINOPATHY; TRENDS; WOUND HEALING;

GUIDED TISSUE REGENERATION; HOMEOSTASIS; HUMANS; MUSCULOSKELETAL DISEASES; OSTEOARTHRITIS; PLATELET-RICH PLASMA; REGENERATION; TENDINOPATHY; WOUND HEALING;

EID: 84929903656     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2015.1026324     Document Type: Review

References (20)

1. Losina E, Weinstein AM, Reichmann WM, et al. Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US. Arthritis Care Res (Hoboken) 2013;65(5):703-11
2. Weinstein AM, Rome BN, Reichmann WM, et al. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am 2013;95(5):385-92
3. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144(5):646-74
4. López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell 2013;153(6):1194-217
5. Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage 2013;21(1):16-21
6. Millar NL, Hueber AJ, Relly JH, et al. Inflammation is present in early human tendinopathy. Am J Sports Med 2010;38(19):2085-91
7. Scanzello CR, Plaas A, Crow MK. Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol 2008;20(5):565-72
8. Andia I, Sanchez M, Maffulli N. Joint pathology and platelet-rich plasma therapies. Expert Opin Biol Ther 2012;12(1):7-22
9. Murab S, Chameettachal S, Bhattacharjee M, et al. Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments. Tissue Eng Part A 2013;19(15-16):1733-53
10. Conboy IM, Rando TA. Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. Cell Cycle 2012;11(12):2260-7
11. Bondeson J. Are we moving in the right direction with osteoarthritis drug discovery? Expert Opin Ther Targets 2011;15(12):1355-68
12. Forbes SJ, Rosenthal N. Preparing the ground for tissue regeneration: from mechanism to therapy. Nat Med 2014;20(8):857-69
13. Hochberg MC. Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies. Osteoarthritis Cartilage 2015;23(Suppl 1):S18-21
14. Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol 2013;9(12):721-30
15. Andia I, Sanchez M, Maffulli N. Tendon healing and platelet-rich plasma therapies. Expert Opin Biol Ther 2010;10(10):1415-26
16. Vangsness CT Jr, Farr J II, Boyd J, et al. Adult human mesenchymal stem cells delivered via intra-Articular injection to the knee following partial medial meniscectomy: a randomized, doubleblind, controlled study. J Bone Joint Surg Am 2014;96(2):90-8
17. Jo CH, Lee YG, Shin WH, et al. Intra-Articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells 2014;32(5):1254-66
18. Wong KL, Lee KB, Tai BC, et al. Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years follow-up. Arthroscopy 2013;29(12):2020-8
19. Orozco L, Munar A, Soler R, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation 2013;95(12):1535-41
20. Andia I, Latorre PM, Gomez MC, et al. Platelet-rich plasma in the conservative treatment of painful tendinopathy: a systematic review and meta-Analysis of controlled studies. Br Med Bull 2014;110(1):99-115