A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: A randomized trial

Pediatric Research

Volumn 77, Issue 6, 2015, Pages 823-828

  Pärtty, Anna ^a   Kalliomäki, Marko ^a   Wacklin, Pirjo ^b   Salminen, Seppo ^c   Isolauri, Erika ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b FINNISH RED CROSS BLOOD SERVICE   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCEIN; METHYLPHENIDATE; OMEGA 3 FATTY ACID; PLACEBO; PROBIOTIC AGENT;

ADOLESCENT; ARTICLE; ASPERGER SYNDROME; ATTENTION DEFICIT DISORDER; BACTEROIDES; BIFIDOBACTERIUM LONGUM; CLOSTRIDIUM HISTOLYTICUM; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENTEROCOCCUS; FECES ANALYSIS; FEMALE; FOLLOW UP; HUMAN; ICD-10; IN SITU HYBRIDIZATION; INFANT; INTESTINE FLORA; LACTOBACILLUS; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SUPPLEMENTATION; AGE; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIFIDOBACTERIUM; DIETARY SUPPLEMENT; FECES; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY;

ADOLESCENT; AGE FACTORS; ASPERGER SYNDROME; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIFIDOBACTERIUM; DIETARY SUPPLEMENTS; FECES; GASTROINTESTINAL MICROBIOME; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; POLYMERASE CHAIN REACTION; PROBIOTICS;

EID: 84929854714     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2015.51     Document Type: Article

References (38)

1. Ustün TB, Ayuso-Mateos JL, Chatterji S, Mathers C, Murray CJ. Global burden of depressive disorders in the year 2000. Br J Psychiatry 2004;184: 386-92.
2. World Health Organization The world health report 2001: Mental health: New understanding, new hope. 2001. http://www.who.int/whr/2001/en/whr01-ch1-en.pdf?ua=1.
3. Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J. Mood and gut feelings. Brain Behav Immun 2010;24:9-16.
4. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. 4th edn. Washington, DC: American Psychiatric Association, 2000.
5. Gargaro BA, Rinehart NJ, Bradshaw JL, Tonge BJ, Sheppard DM. Autism and ADHD: How far have we come in the comorbidity debate? Neurosci Biobehav Rev 2011;35:1081-8.
6. Pasini A, D'Agati E, Pitzianti M, Casarelli L, Curatolo P. Motor examination in children with Attention-deficit/hyperactivity Disorder and Asperger Syndrome. Acta Paediatr 2012;101:e15-8.
7. Thapar A, Cooper M, Jefferies R, Stergiakouli E. What causes attention deficit hyperactivity disorder? Arch Dis Child 2012;97:260-5.
8. Bercik P, Verdu EF, Foster JA, et al. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology 2010;139:2102-2112.e1.
9. Bercik P, Park AJ, Sinclair D, et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil 2011;23:1132-9.
10. Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 2011;23:255-64, e119.
11. Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 2011;108:16050-5.
12. Messaoudi M, Lalonde R, Violle N, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 2011;105:755-64.
13. Tillisch K, Labus J, Kilpatrick L, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013;144:1394-401, 1401.e1-4.
14. Tsai MC, Lin HK, Lin CH, Fu LS. Prevalence of attention deficit/hyperactivity disorder in pediatric allergic rhinitis: A nationwide population-based study. Allergy Asthma Proc 2011;32:41-6.
15. Meldrum SJ, D'Vaz N, Dunstan JA, et al. Allergic disease in the first year of life is associated with differences in subsequent neurodevelopment and behaviour. Early Hum Dev 2012;88:567-73.
16. Sprich S, Biederman J, Crawford MH, Mundy E, Faraone SV. Adoptive and biological families of children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry 2000;39:1432-7.
17. Lichtenstein P, Carlström E, Råstam M, Gillberg C, Anckarsäter H. The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am J Psychiatry 2010;167:1357-63.
18. Langley K, Rice F, Van den Bree MB, Thapar A. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review. Minerva Pediatr 2005;57:359-71.
19. Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJ. Cognitive and behavioral outcomes of school-aged children who were born preterm: A meta-analysis. JA MA 2002;288:728-37.
20. Aarnoudse-Moens CS, Weisglas-Kuperus N, Van Goudoever JB, Oosterlaan J. Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pe diatrics 2009;124:717-28.
21. Pelsser LM, Frankena K, Toorman J, Savelkoul HF, Pereira RR, Buitelaar JK. A randomised controlled trial into the effects of food on ADHD. Eur Child Adolesc Psychiatry 2009;18:12-9.
22. Pelsser LM Frankena K Toorman J et al. Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): A randomised controlled trial. Lancet 2011 377 494-503.
23. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection meth ods. J Pediatr Gastroenterol Nutr 2000;30:61-7.
24. Shelton KH, Collishaw S, Rice FJ, Harold GT, Thapar A. Using a genetically informative design to examine the relationship between breastfee ding and childhood conduct problems. Eur Child Adolesc Psychiatry 2011;20:571-9.
25. Isolauri E, Kalliomäki M, Laitinen K, Salminen S. Modulation of the maturing gut barrier and microbiota: A novel target in allergic disease. Curr Pharm Des 2008;14:1368-75.
26. Enticott PG, Rinehart NJ, Tonge BJ, Bradshaw JL, Fitzgerald PB. A preliminary transcranial magnetic stimulation study of co rtical inhibition and excitability in high-functioning autism and Asperger disorder. Dev Med Child Neurol 2010;52:e179-83.
27. Gareau MG, Wine E, Rodrigues DM, et al. Bacterial infection causes stres sinduced memory dysfunction in mice. Gut 2011;60:307-17.
28. Cryan JF, O'Mahony SM. The microbiome-gut-brain axis: From bowel to behavior. Neurogastroenterol Motil 2011;23:187-92.
29. Neufeld KA, Kang N, Bienenstock J, Foster JA. Effects of intestinal microbiota on anxiety-like behavior. Commun Integr Biol 2011;4:492-4.
30. Kalliomäki M, Salmine n S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: A randomised placebocontrolled trial. Lancet 2001;357:1076-9.
31. Kalliomäki M, Laipp ala P, Korvenranta H, Kero P, Isolauri E. Extent of fussing and colic type crying preceding atopic disease. Arch Dis Child 2001;84:349-50.
32. Barr RG, Kramer MS, Boisjoly C, McVey-Wh ite L, Pless IB. Parental diary of infant cry and fuss behaviour. Arch Dis Child 1988;63:380-7.
33. Nylund L, Heilig HG, Salminen S, De Vos WM, Satokari R. Semi-automated extraction of microbial DNA from feces for qPCR and phylogenetic microarray analysis. J Microbiol Methods 2010;83:231-5.
34. Collado MC, Isolauri E, Laitinen K, Salminen S. Distinct composition of gut micr obiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 2008;88:894-9.
35. Scalabrin DM Mitmesser SH Welling GW et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants.J Pediatr Gastroenterol Nutr2012. 54. 343-52.
36. Kalliomäki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 2001;107:129-34.
37. Wacklin P, Mäkivuokko H, Alakulppi N, et al. Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine. PLoS One 2011;6:e20113.
38. Parmar AS, Alakulppi N, Paavola-Sakki P, et al. Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population. Tissue Antigens 2012; 80:488-93.