Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 14, 2015, Pages 4322-4327

  Blachly, James S ^a   Ruppert, Amy S ^a   Zhao, Weiqiang ^a   Long, Susan ^a   Flynn, Joseph ^a   Flinn, Ian ^b   Jones, Jeffrey ^a   Maddocks, Kami ^a   Andritsos, Leslie ^a   Ghia, Emanuela M ^c   Rassenti, Laura Z ^c   Kipps, Thomas J ^c   De La Chapelle, Albert ^a   Byrd, John C ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b SARAH CANNON RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

B cells; CLL; Immunoglobulin; RNA sequencing; Somatic hypermutation

Indexed keywords

EPITOPE; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RNA; COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN VARIABLE REGION; RECOMBINASE; TRANSCRIPTOME;

AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CANCER PROGNOSIS; CELL MATURATION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; COMPLEMENTARITY DETERMINING REGION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA SEQUENCE; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC HYPERMUTATION; SOMATIC MUTATION; ALLELE; CHEMISTRY; GENETICS; GENOME; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROCEDURES; PROGNOSIS; SEQUENCE ANALYSIS;

ALLELES; BASE SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; GENOME; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROGNOSIS; SEQUENCE ANALYSIS, RNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSCRIPTOME; VDJ RECOMBINASES;

EID: 84929658167     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503587112     Document Type: Article

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