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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 9, 2015, Pages 1831-1835

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2)

(29) Singh, Sheo B a Kaelin, David E a Wu, Jin a Miesel, Lynn a Tan, Christopher M a Black, Todd a Nargund, Ravi a Meinke, Peter T a Olsen, David B a Lagrutta, Armando a Lu, Jun a Patel, Sangita a Rickert, Keith W a Smith, Robert F a Soisson, Stephen a Sherer, Edward a Joyce, Leo A a Wei, Changqing b Peng, Xuanjia b Wang, Xiu b more..

a MERCK RESEARCH LABORATORIES (United States)

b WUXI APPTEC (China)

c KYORIN PHARMACEUTICAL CO LTD (Japan)

Author keywords

Antibacterial; Bacterial topoisomerase inhibitors; Broad spectrum; Gyrase inhibitors; ParC inhibitors; Tricyclic 1,5 naphthyridinone

Indexed keywords

1,5-NAPHTHYRIDINONE OXABICYCLOOCTANE; ANTIINFECTIVE AGENT; CYCLOOCTANE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; NAPHTHYRIDINE DERIVATIVE;

CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CYCLOOCTANES; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84929653955 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.03.044 Document Type: Article

Times cited : (33)

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