Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach

Journal of Controlled Release

Volumn 210, Issue , 2015, Pages 48-57

  Rose, Fabrice ^a   Wern, Jeanette Erbo ^b   Ingvarsson, Pall Thor ^a   Van De Weert, Marco ^a   Andersen, Peter ^b   Follmann, Frank ^b   Foged, Camilla ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

Adjuvant; Dimethyldioctadecylammonium (DDA); Drug delivery; Nanomedicine; Nanoparticles; PLGA; Quality by design (QbD); Trehalose 6,6 dibehenate; Vaccine

Indexed keywords

ACETONE; ANTIBODIES; CATIONIC SURFACTANTS; EMULSIFICATION; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; LINEAR REGRESSION; LIPID BILAYERS; LIPOSOMES; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; POLYDISPERSITY; STRUCTURAL OPTIMIZATION; VACCINES; ZETA POTENTIAL;

ADJUVANT; DIMETHYLDIOCTADECYLAMMONIUM (DDA); PLGA; QUALITY BY DESIGNS; TREHALOSE 6,6-DIBEHENATE;

DRUG DELIVERY;

ACETONE; CATIONIC SURFACTANT; DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; HYDROCARBON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; INTERFERON; INTERLEUKIN 17; INTERLEUKIN 5; LIPOSOME; MAJOR OUTER MEMBRANE PROTEIN; MICROSPHERE; NANOPARTICLE; NANOSHELL; OUTER MEMBRANE PROTEIN; POLYGLACTIN; POLYVINYL ALCOHOL; TREHALOSE 6,6' DIBEHENATE; UNCLASSIFIED DRUG; DIMETHYLDIOCTADECYLAMMONIUM; GLYCOLIPID; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; QUATERNARY AMMONIUM DERIVATIVE; SURFACTANT; TREHALOSE 6,6'-DIBEHENATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; CRITICAL PROCESS PARAMETER; CRITICAL QUALITY ATTRIBUTE; DESIGN OF EXPERIMENT; DISPERSION; EMULSION; ENTHALPY; FEMALE; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; ISOMERIZATION; LIPID BILAYER; LIPID MEMBRANE; MEMBRANE STRUCTURE; METHODOLOGY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPTIMAL OPERATION SPACE; PARTICLE SIZE; PHASE TRANSITION; PHYSICAL PARAMETERS; POLYDISPERSITY INDEX; PRIORITY JOURNAL; PROCESS DESIGN; QUALITY BY DESIGN APPROACH; QUALITY TARGET PRODUCT PROFILE; SPLEEN CELL; STATIC ELECTRICITY; SURFACE CHARGE; SURFACE TENSION; TH1 CELL; TH17 CELL; THERMOGRAPHY; THERMOTROPIC PHASE BEHAVIOR; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; CHEMISTRY; DRUG DESIGN; ULTRASTRUCTURE;

ADJUVANTS, IMMUNOLOGIC; DRUG DESIGN; GLYCOLIPIDS; LACTIC ACID; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; POLYGLYCOLIC ACID; QUATERNARY AMMONIUM COMPOUNDS; SURFACE-ACTIVE AGENTS;

EID: 84929620631     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.05.004     Document Type: Article

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