Development and validation of in vitro-in vivo correlation (IVIVC) for estradiol transdermal drug delivery systems

Journal of Controlled Release

Volumn 210, Issue , 2015, Pages 58-66

  Yang, Yang ^a   Manda, Prashanth ^a   Pavurala, Naresh ^a   Khan, Mansoor A ^a   Krishnaiah, Yellela S R ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Absorption; Estradiol; In vitro in vivo correlation (IVIVC); Permeation; Transdermal; Validation

Indexed keywords

ABSORPTION; BODY FLUIDS; COMMERCE; PERMEATION; PRODUCT DESIGN;

ESTRADIOL; IN-VITRO; PLASMA CONCENTRATION; POLYNOMIAL REGRESSION; POSTMENOPAUSAL WOMEN; TRANSDERMAL; TRANSDERMAL DRUG DELIVERY SYSTEMS; VALIDATION;

DRUG PRODUCTS;

ESTRADIOL; ESTROGEN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CADAVER; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG FORMULATION; DRUG PENETRATION; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TRANSDERMAL DRUG DELIVERY SYSTEM; BIOAVAILABILITY; BIOLOGICAL MODEL; BLOOD; CROSSOVER PROCEDURE; CUTANEOUS DRUG ADMINISTRATION; DRUG DELIVERY SYSTEM; HORMONE SUBSTITUTION; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; REPRODUCIBILITY; SKIN; SKIN ABSORPTION; YOUNG ADULT;

ADMINISTRATION, CUTANEOUS; ADULT; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DRUG DELIVERY SYSTEMS; ESTRADIOL; ESTROGENS; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; IN VITRO TECHNIQUES; MIDDLE AGED; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; SKIN; SKIN ABSORPTION; YOUNG ADULT;

EID: 84929581296     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.05.263     Document Type: Article

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