Gleditsia sinensis thorn extract inhibits the proliferation and migration of PDGF-induced vascular smooth muscle cells

Molecular Medicine Reports

Volumn 10, Issue 4, 2014, Pages 2031-2038

  Park, Sung Soo ^a   Kim, Wun Jae ^b   Moon, Sung Kwon ^c  

^a Jeju National University   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

^c Chung Ang University   (South Korea)

Author keywords

Ethanol extract of gleditsia sinensis thorns; Invasion; Migration; p27KIP1; PDGF; VSMCs

Indexed keywords

ALCOHOL; CARDIOVASCULAR AGENT; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; GELATINASE B; GLEDITSIA SINENSIS EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; PROTEIN BINDING;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL ACTIVATION; CELL INVASION; CELL INVASION ASSAY; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG INHIBITION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GLEDITSIA; GLEDITSIA SINENSIS; GROWTH INHIBITION; LIGHT CHAIN; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; WOUND HEALING; ZYMOGRAPHY; ANIMAL; CELL CULTURE; CELL MOTION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; G1 PHASE CELL CYCLE CHECKPOINTS; GLEDITSIA; MALE; MATRIX METALLOPROTEINASE 9; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; PHOSPHORYLATION; PLANT EXTRACTS; PLATELET-DERIVED GROWTH FACTOR; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP-1;

EID: 84929517668     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2422     Document Type: Article

References (28)

1. Ross R: Cell biology of atherosclerosis. Annu Rev Physiol 57: 791-804, 1995.
2. Dzau VJ, Braun-Dullaeus RC and Sedding DG: Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med 8: 1249-1256, 2002. (Pubitemid 35373556)
3. Doran AC, Meller N and McNamara CA: Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol 28: 812-819, 2008. (Pubitemid 351544093)
4. Heldin CH and Westermark B: Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79: 1283-1316, 1999. (Pubitemid 29473317)
5. Zhan Y, Kim S, Izumi Y, Izumiya Y, Nakao T, Miyazaki H and Iwao H: Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression. Arterioscler Thromb Vasc Biol 23: 795-801, 2003. (Pubitemid 36566168)
6. Sherr CJ: G1 phase progression: cycling on cue. Cell 79: 551-555, 1994.
7. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993. (Pubitemid 24036020)
8. Toyoshima H and Hunter T: p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78: 67-74, 1994. (Pubitemid 24228301)
9. Newby AC and Zaltsman AB: Molecular mechanisms in intimal hyperplasia. J Pathol 190: 300-309, 2000. (Pubitemid 30141376)
10. Cho A and Reidy MA: Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circ Res 91: 845-851, 2002. (Pubitemid 35285083)
11. Galis ZS, Johnson C, Godin D, Magid R, Shipley JM, Senior RM and Ivan E: Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circ Res 91: 852-859, 2002. (Pubitemid 35285084)
12. Cho A, Graves J and Reidy MA: Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20: 2527-2532, 2000.
13. Moon SK, Cha BY and Kim CH: ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway. J Cell Physiol 198: 417-427, 2004. (Pubitemid 38235037)
14. Dollery CM, McEwan JR and Henney AM: Matrix metalloproteinases and cardiovascular disease. Circ Res 77: 863-868, 1995.
15. Hansson GK and Robertson AK: TGF-beta in atherosclerosis. Arterioscler Thromb Vasc Biol 24: E137, 2004.
16. Lim JC, Park JH, Budesinsky M, Kasal A, Han YH, Koo BS, Lee SI and Lee DU: Antimutagenic constituents from the thorns of Gleditsia sinensis. Chem Pharm Bull (Tokyo) 53: 561-564, 2005. (Pubitemid 40740627)
17. Zhou L, Li D, Wang J, Liu Y and Wu J: Antibacterial phenolic compounds from the spines of Gleditsia sinensis Lam. Nat Prod Res 21: 283-291, 2007. (Pubitemid 46729923)
18. Li WH, Zhang XM, Tian RR, Zheng YT, Zhao WM and Qiu MH: A new anti-HIV lupane acid from Gleditsia sinensis Lam. J Asian Nat Prod Res 9: 551-555, 2007.
19. Shin TY and Kim DK: Inhibitory effect of mast cell-dependent anaphylaxis by Gleditsia sinensis. Arch Pharm Res 23: 401-406, 2000.
20. Park E and Shin MJ: Anti-inflammatory activity of aqueous extract from Gleditsiae Spina. J Pharmaceut Soc Korea 37: 124-128, 1993.
21. Lee SJ, Cho YH, Kim H, Park K, Park SK, Ha SD, Kim WJ and Moon SK: Inhibitory effects of the ethanol extract of Gleditsia sinensis thorns on human colon cancer HCT116 cells in vitro and in vivo. Oncol Rep 22: 1505-1512, 2009.
22. Zhou L, Li D, Jiang W, Qin Z, Zhao S, Qiu M and Wu J: Two ellagic acid glycosides from Gleditsia sinensis Lam. with antifungal activity on Magnaporthe grisea. Nat Prod Res 21: 303-309, 2007. (Pubitemid 46729926)
23. Lee SJ, Park SS, Kim WJ and Moon SK: Gleditsia sinensis thorn extract inhibits proliferation and TNF-α-induced MMP-9 expression in vascular smooth muscle cells. Am J Chin Med 40: 373-386, 2012.
24. Tanner FC, Yang ZY, Duckers E, Gordon D, Nabel GJ and Nabel EG: Expression of cyclin-dependent kinase inhibitors in vascular disease. Circ Res 82: 396-403, 1998. (Pubitemid 28101197)
25. Chen D, Krasinski K, Sylvester A, Chen J, Nisen PD and Andrés V: Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery. J Clin Invest 99: 2334-2341, 1997. (Pubitemid 27227709)
26. Moon SK, Kim HM, Lee YC and Kim CH: Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. J Biol Chem 279: 33063-33070, 2004. (Pubitemid 39062949)
27. Shankland SJ and Wolf G: Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. Am J Physiol Renal Physiol 278: F515-F529, 2000. (Pubitemid 30215229)
28. Uchida K, Sasahara M, Morigami N, Hazama F and Kinoshita M: Expression of platelet-derived growth factor B-chain in neointimal smooth muscle cells of balloon injured rabbit femoral arteries. Atherosclerosis 124: 9-23, 1996. (Pubitemid 26188203)