Conformational instability governed by disulfide bonds partitions the dominant from subdominant helper T-cell responses specific for HIV-1 envelope glycoprotein gp120

Vaccine

Volumn 33, Issue 25, 2015, Pages 2887-2896

  Nguyen, Hong Nam P ^a   Steede, N Kalaya ^a   Robinson, James E ^a   Landry, Samuel J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; Antigen processing; Cellular immune response; Disulfide; Lymphocyte; Protein conformation; Protein denaturation; T helper

Indexed keywords

EPITOPE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOREDUCTASE; GLYCOPROTEIN GP 120; UNCLASSIFIED DRUG; DISULFIDE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IFI30 PROTEIN, MOUSE; OXIDOREDUCTASE;

ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; DISULFIDE BOND; DRUG CONFORMATION; FEMALE; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; VIRUS ENVELOPE; VIRUS LOAD; VIRUS STRAIN; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELLULAR IMMUNITY; CHEMISTRY; DEFICIENCY; EPITOPE MAPPING; HUMAN; IMMUNOLOGY; PROTEIN CONFORMATION; PROTEIN DENATURATION;

AIDS VACCINES; AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; DISULFIDES; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HIV ENVELOPE PROTEIN GP120; HUMANS; IMMUNITY, CELLULAR; IMMUNIZATION; IMMUNODOMINANT EPITOPES; MICE, INBRED C57BL; OXIDOREDUCTASES; PROTEIN CONFORMATION; PROTEIN DENATURATION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84929515864     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.04.082     Document Type: Article

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