Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes

Biomedical Microdevices

Volumn 16, Issue 5, 2014, Pages 727-736

  Maher, Steven P ^a,b   Crouse, Richard B ^a   Conway, Amy J ^a   Bannister, Emilee C ^a   Achyuta, Anil Kumar H ^a   Clark, Amy Y ^a   Sinatra, Francy L ^a   Cuiffi, Joseph D ^a   Adams, John H ^b   Kyle, Dennis E ^b   Saadi, Wajeeh M ^a  

^a CHARLES STARK DRAPER LABORATORY   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Albumin; CYP3A4; Factor IX; Human hepatocytes; Microfluidics; Organmicroenvironment

Indexed keywords

CELL ENGINEERING;

ALBUMIN; CYP3A4; FACTOR IX; HUMAN HEPATOCYTES; ORGANMICROENVIRONMENT;

MICROFLUIDICS;

ALBUMIN; BLOOD CLOTTING FACTOR 9; CYTOCHROME P450 3A4; PROTEIN; PROTEIN FAH; RAG2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COCULTURE; CONTROLLED STUDY; DRUG METABOLISM; GENERAL DEVICE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRAHEPATIC BILE DUCT; LIVER CELL CULTURE; LIVER FUNCTION; LIVER SINUSOID; MICROENVIRONMENT; MICROFLUIDIC BILAYER DEVICE; MICROFLUIDICS; MONOCULTURE; PHENOTYPIC VARIATION; PRIMARY CELL; PRIORITY JOURNAL; ANIMAL; CELL PROLIFERATION; CULTURE TECHNIQUE; CYTOLOGY; DEVICES; HEPG2 CELL LINE; LIVER; LIVER CELL; METABOLISM; MICROFLUIDIC ANALYSIS; MOUSE; PROCEDURES;

ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MICE; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 84929511491     PISSN: 13872176     EISSN: 15728781     Source Type: Journal    
DOI: 10.1007/s10544-014-9877-x     Document Type: Article

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