Normothermic donor heart perfusion: Current clinical experience and the future

Transplant International

Volumn 28, Issue 6, 2015, Pages 634-642

  Messer, Simon ^a   Ardehali, Abbas ^b   Tsui, Steven ^a  

^a PAPWORTH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ex vivo; heart; normothermic; perfusion; transplant

Indexed keywords

AORTA PRESSURE; BODY TEMPERATURE; COLD ISCHEMIA; HEALTH CARE QUALITY; HEART GRAFT; HEART LUNG PREPARATION; HEART PERFUSION; HEART PRESERVATION; HEART TRANSPLANTATION; HUMAN; INTRAAORTIC BALLOON PUMP; NONHUMAN; PRIORITY JOURNAL; REVIEW; STARLING LAW; ANIMAL; BRAIN DEATH; CLINICAL TRIAL (TOPIC); DONOR; EQUIPMENT DESIGN; HEART; ORGAN PRESERVATION; PERFUSION; PHYSIOLOGY; PROCEDURES; REGISTER; TIME FACTOR;

ANIMALS; BRAIN DEATH; CLINICAL TRIALS AS TOPIC; COLD ISCHEMIA; EQUIPMENT DESIGN; HEART; HEART TRANSPLANTATION; HUMANS; ORGAN PRESERVATION; PERFUSION; REGISTRIES; TIME FACTORS; TISSUE DONORS;

EID: 84929501978     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12361     Document Type: Review

References (40)

1. NHSBT (2012 -2013). Organ Donation and Transplantation- Activity figures for the UK as at 12 April 2013. Available at http://www.organdonation.nhs.uk/statistics/transplant-activity-report/archive-activity-reports/pdf/ukt/activity-report-2011-12.pdf
2. NHSBT (2012 -2013). Cardiothoracic Activity. Available at http://www.organdonation.nhs.uk/statistics/transplant-activity-report/current-activity-reports/ukt/cardiothoracic-activity.pdf
3. BHF Coronary heart disease statistics. A compendium of health statistics. 2012 edition. Available at http://www.bhf.org.uk/research/heart-statistics/heart-statistics-publications.aspx
4. Stehlik J, Edwards LB, Kucheryavaya AY, et al,. The Registry of International Society of Heart and Lung Transplantation: 29th official adult heart transplant report. J Heart Lung Transplant 2012; 31: 1052.
5. Banner NR, Thomas HL, Curnow E, et al,. The importance of cold and warm ischaemia for survival after heart transplantation. Transplantation 2008; 86: 542.
6. Segovia J, Cosio DG, Barcelo JM, et al,. RADIAL: a novel primary graft failure risk score in heart transplantation. J Heart Lung Transplant 2011; 30: 644.
7. Marasco S, Esmore D, Negri J, et al,. Early institution of mechanical support improves outcomes in primary cardiac allograft failure. J Heart Lung Transplant 2005; 24: 2037.
8. Buckburg GD, Brazier JR, Nelson RL, et al,. Studies of the effects of hypothermia on regional myocardial flow and metabolism during cardiopulmonary bypass. I. The adequately perfused beating, fibrillating, and arrested heart. J Thorac Cardiovasc Surg 1997; 73: 87.
9. Ozeki T, Kwon M, Gu J, et al,. Heart preservation using continuous ex vivo perfusion improves viability and functional recovery. Circ J 2007; 71: 153.
10. Fitton TP, Wei C, Lin R, et al,. Impact of 24h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress. Clin Transplant 2004; 18: 22.
11. Peltz M, Cobert ML, Rosenbaum DH, West LM, Jessen ME,. Myocardial perfusion characteristics during machine perfusion for heart transplantation. Surgery 2008; 144: 225.
12. Wicomb W, Boyd ST, Cooper DKC, Rose AG, Barnard CN,. Ex vivo functional evaluation of pig hearts subjected to 24 hours preservation by hypothermic perfusion. S Afr Med J 1981; 60: 245.
13. Zimmer HG,. The isolated perfused heart and its pioneers. News Physiol Sci 1998; 13: 203.
14. Taegtmeyer H,. One hundred years ago: Oscar Langendorff and the birth of cardiac metabolism. Can J Cardiol 1995; 11: 1030.
15. Broadley KJ,. The Langendorff heart preparation-reappraisal of its role as a research and teaching model for coronary vasoactive drugs. J Pharmacol Methods 1979; 2: 143.
16. Neely JR, Liebermesiter H, Battersby EJ, Morgan HE,. Effect of pressure development on oxygen consumption by isolated rat heart. Am J Phsiol 1967; 212: 804.
17. Starling EH, Visscher MB,. The regulation of the energy output of the heart. J Physiol 1926; 62: 243.
18. Robicsek F, Sanger P, Taylor F,. Simple method of keeping the heart "alive" and functioning outside of the body for prolonged periods. Surgery 1963; 53: 525.
19. Robicsek F, Lesage A, Sanger P, Daugherty H, Gallucci V, Bagby E,. Transplantation of "Live Hearts". Am J Cardiol 1967; 20: 803.
20. Ladowski JS, Kapelanski DP, Teodori MF, Stevenson WC, Hardesty RL, Griffith BP,. Use of autoperfsuion for distant procurement of heart-lung allografts. J Heart Transplant 1985; 4: 330.
21. Hassanein WH, Zellos L, Tyrrell TA, et al,. Continuous perfusion of donor hearts in the beating state extends preservation time and improves recovery of function. J Thorac Cardiovasc Surg 1998; 116: 821.
22. Hamed A, Tsui S, Huber J, Lin R, Poggio EC, Ardehali A,. A Serum lactate is a highly specific predictor of post cardiac transplant outcomes using the Organ Care System. J Heart Lung Transplant 2009; 28: S71.
23. Tsui S, Dhital K, Eisenring C, Ardehali A,. Ex-vivo assessment of donor hearts with the OCS to detect hidden pathologies. J Heart Lung Transplant 2008; 27: S200.
24. Ghodsizad A, Bordel V, Ungerer M, Karck M, Bekeredjian R, Ruhparwar A,. Ex vivo coronary angiography of a donor heart in the organ care system. Heart Surg Forum 2012; 15: 2011.
25. Hassanein AH, Elbatanony A, Abdelaziem A, Solomon S,. The Organ Care System (OCS) enables ex vivo assessment of donor heart coronary perfusion using contrast echocardiography. J Heart Lung Transplant 2009; 28: S150.
26. Van Raemdonck D, Neyrinck A, Rega F, Devos R, Pirenne J,. Machine perfusion in organ transplantation: a tool for ex-vivo graft conditioning with mesenchymal stem cells? Curr Opin Organ Transplant 2013; 18: 1087.
27. Goldsmith KA, Demiris N, Gooi JH, et al,. Life-years gained by reducing donor heart ischaemic times. Transplantation 2009; 87: 243.
28. Schnitzler MA, Hauptman PJ, Takemoto SK, et al,. The impact of cold ischaemia time on life year benefit of heart transplantation. Am J Transplant 2006; 6: 382.
29. Sutherland FJ, Hearse DJ,. The isolated blood and perfusion fluid perfused heart. Pharmacol Res 2000; 41: 613.
30. Ali AA, Lim E, Thanikachalam M, et al,. Cardiac arrest in the organ donor does not negatively influence recipient survival after heart transplantation. Eur J Cardiothorac Surg 2007; 31: 929.
31. Southerland KW, Castleberry AW, Williams JB, Daneshmand MA, Ali AA, Milano CA,. Impact of donor cardiac arrest on heart transplantation. Surgery 2013; 154: 312.
32. Gundry SR, Fukushima N, Eke CC, Hill AC, Zuppan C, Bailey LL,. Successful survival of primates receiving transplantation with "dead", non beating donor hearts. J Thorac Cardiovasc Surg 1995; 109: 1097.
33. Gundry SR, Alonso de Begona J, Kawauchi M, Liu H, Razzouk AJ, Bailey LL,. Transplantation and reanimation of hearts removed from donors 30 minutes after warm, asystolic 'death'. Arch Surg 1993; 128: 989.
34. White CW, Ali A, Hasanally D, et al,. A cardioprotective preservation strategy employing ex vivo heart perfusion facilitates successful transplant of donor hearts after cardiocirculatory death. J Heart Lung Transplant 2013; 32: 734.
35. Barnard CN,. The operation. A human cardiac transplant: an interim report of successful operation performed at Groote Schuur Hospital, Cape Town. S Afr Med J 1967; 30: 1271.
36. Boucek MM, Mashburn C, Dunn SM, et al,. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med 2008; 359: 709.
37. Rapse S, Pepe S, Anderson J, Mclean C, Rosenfeldt FL,. Cardiac reanimation for donor heart transplantation after cardiocirculatory death. J Heart Lung Transplant 2010; 29: 747.
38. Ali AA, White P, Xiang B, et al,. Hearts from DCD donors display acceptable biventricular function after heart transplantation in pigs. Am J Transplant 2011; 11: 1621.
39. Iyer A, Gao L, Doyle A, et al,. Hearts from Donation after Circulatory Death (DCD) Donors- Assessment in porcine transplant model utilising TransMedics Organ Care System for Organ Perfusion Preservation. J Heart Lung Transplant 2013; 32: S68.
40. Noterdaeme T, Detry O, Hans MF, et al,. What is the potential increase in the heart graft pool by cardiac donation after circulatory death? Transpl Int 2013; 26: 61.